1-Boc-hexahydro-1,4-diazepine

ChemicalBook > CAS DataBase List > 1-Boc-hexahydro-1,4-diazepine

1-Boc-hexahydro-1,4-diazepine

Product Name: 1-Boc-hexahydro-1,4-diazepine
CAS No.: 112275-50-0
Chemical Name: 1-Boc-hexahydro-1,4-diazepine
Synonyms: TERT-BUTYL 1,4-DIAZEPANE-1-CARBOXYLATE;1-BOC-HOMOPIPERAZINE;HPBOC;BOC-HOPIZ;BOC-HOPAZ;Boc-HomoPiz;Boc-HoPaz*HCl;Boc-HoPiz, liq.;BUTTPARK 27\08-71;BOC-HOMOPIPERAZINE
CBNumber: CB8230427
Molecular Formula: C10H20N2O2
Formula Weight: 200.28
MOL File: 112275-50-0.mol

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1-Boc-hexahydro-1,4-diazepine Property

Melting point:: 143.4 °C
Boiling point:: 95-110 °C0.5 mm Hg(lit.)
Density: 1.016 g/mL at 20 °C(lit.)
refractive index: n20/D 1.471(lit.)
Flash point:: >230 °F
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
pka: 10.45±0.20(Predicted)
form: Liquid
Specific Gravity: 1.016
color: Colorless to yellow
Water Solubility: Not miscible or difficult to mix in water.
Sensitive: Air Sensitive
BRN: 7581789
CAS DataBase Reference: 112275-50-0(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
RIDADR: 2735
WGK Germany: 3
F: 10-34
Hazard Note: Irritant
HazardClass: IRRITANT, KEEP COLD
HazardClass: 8
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 511382
Product name: 1-Boc-hexahydro-1,4-diazepine
Purity: 98%
Packaging: 5g
Price: $131
Updated: 2024/03/01

Alfa Aesar

Product number: L17728
Product name: 1-Boc-homopiperazine, 98%
Packaging: 1g
Price: $44.65
Updated: 2024/03/01

Alfa Aesar

Product number: L17728
Product name: 1-Boc-homopiperazine, 98%
Packaging: 5g
Price: $117.65
Updated: 2024/03/01

TRC

Product number: B656175
Product name: 1-Boc-hexahydro-1,4-diazepine
Packaging: 2g
Price: $105
Updated: 2021/12/16

Usbiological

Product number: 265573
Product name: Boc-homopiperazine
Packaging: 2g
Price: $333
Updated: 2021/12/16

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1-Boc-hexahydro-1,4-diazepine Chemical Properties,Usage,Production

Chemical Properties

Colorless to yellow liquid

Uses

1-Boc-hexahydro-1,4-diazepine is a diazepine derivative used in the preparation of pharmaceutical compounds such as histamine H3-receptor antagonists and dipeptidyl peptidase IV (DPP-IV) inhibitors.

Uses

1-Boc-homopiperazine is used in synthesis of potent anticoagulant. It is also used to produce 4-(7,8,9,10-tetrahydro-6H-cyclohepta[b]quinolin-11-yl)-[1,4]diazepane-1-carboxylic acid tert-butyl ester by reaction with 11-bromo-7,8,9,10-tetrahydro-6H-cyclohepta[b]quinoline.

General Description

1-Boc-hexahydro-1,4-diazepine is an N-boc protected homopiperazine. Its enthalpy of vaporization at boiling point (558.15K) is 49.498kjoule/mol.

Synthesis

To a solution of di-tert-butyldicarbonate (2.201 g, 9.780 mmol) in acetic acid (9.8 mL), a solution of 1,4-diazepane (1.0 g, 9.780 mmol) in acetic acid (9.8 mL) is added at room temperature. After 24 hours, water is added and the pH is adjusted to 10 using 10% NaOH. The aqueous phase is then extracted with dichloromethane (2 x 15 mL). The organic phase is dried and the solvent is evaporated to obtain tert-butyl 1,4-diazepane-1-carboxylate (1-Boc-hexahydro-1,4-diazepine) with a yield of 90.0%.

Precautions

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store under inert gas. It is sensitive to air.

References

Synthesis and biological activity of novel 1,4-diazepane derivatives as factor Xa inhibitor with potent anticoagulant and antithrombotic activity. Bioorganic &Medicinal Chemistry. 2004, 12 (9), 2179-2191.
Discovery and structure-activity relationship of thienopyridine derivatives as bone anabolic agents. Bioorganic & medicinal chemistry. 2013, 21 (7), 1628-1642.

1-Boc-hexahydro-1,4-diazepine Preparation Products And Raw materials

Raw materials

t-butyl chloroformate Sodium acetate Ethylenediamine Ethanol tert-Butyl methyl ether Potassium hydroxide Acetone Sodium sulfate Toluene Di-tert-butyl dicarbonate Benzyltriethylammonium bromide Phenol Potassium carbonate Sodium Chloroform N,N'-Bis(ethylene)-p-Toluenesulfonamide Sulfurous Acid 1,3-Dibromopropane Tosyl chloride Hydrogen bromide Diethyl ether Homopiperazine Ethyl acetate Benzhydrylamine Hydrochloric acid Sodium bicarbonate Acetic acid Methanol Sodium hydroxide Tetrabutylammonium fluoride 1-Butanol Magnesium sulfate Sulfuric acid

Preparation Products

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View Lastest Price from 1-Boc-hexahydro-1,4-diazepine manufacturers

Career Henan Chemical Co

Product: 1-Boc-hexahydro-1,4-diazepine 112275-50-0
Price: US $8.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10tons
Release date: 2018-12-24

112275-50-0, 1-Boc-hexahydro-1,4-diazepineRelated Search:

1-N-Boc-5-oxo-1,4-diazepane 1-Boc-hexahydro-1,4-diazepine TETRT-BUTYL5-METHYL-1,4-DIAZEPANE-1-CARBOXYLATE Homopiperazine CYCLOHEPTANE 1-BOC-4-(CARBOXY-NAPHTHALEN-2-YL-METHYL)-[1,4]DIAZEPANE 1-BOC-4-(CARBOXY-THIOPHEN-3-YL-METHYL)-[1,4]DIAZEPANE 1-BOC-4-[CARBOXY-(1H-INDOL-2-YL)-METHYL]-[1,4]DIAZEPANE 4-(carboxy-p-tolyl-methyl)-[1,4]diazepane-1-carboxylic acid tert-butyl ester 1-BOC-4-(CARBOXY-PYRIDIN-3-YL-METHYL)-[1,4]DIAZEPANE 1-BOC-4-(BENZOFURAN-2-YL-CARBOXY-METHYL)-[1,4]DIAZEPANE 5-CYANO-2-[4-BUTOXYCARBONYL-1-(1,4-DIAZEPENYL)]-PYRIDINE 1-BOC-4-(CARBOXY-FURAN-2-YL-METHYL)-[1,4]DIAZEPANE 1-BOC-4-(CARBOXY-THIOPHEN-2-YL-METHYL)-[1,4]DIAZEPANE di(tert-butyl) 1,4-diazepane-1,4-dicarboxylate 1-BOC-4-(CARBOXY-PYRIDIN-4-YL-METHYL)-[1,4]DIAZEPANE BUTTPARK 75\08-55 TERT-BUTYL 4-[2-NITRO-4-(TRIFLUOROMETHYL)PHENYL]-1,4-DIAZEPANE-1-CARBOXYLAT E

[1,4]DIAZEPANE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

1-BOC-HEXAHYDRO-1,4-DIAZEPINE

1-BOC-HOMOPIPERAZINE

1-BOC-1,4-DIAZEPANE

TERT-BUTYL HOMOPIPERAZINE-1-CARBOXYLATE

TERT-BUTYL 1,4-DIAZEPANE-1-CARBOXYLATE

TERT-BUTYL 1-HOMOPIPERAZINECARBOXYLATE

N-(T-BUTYLOXYCARBONYL)-HOMOPIPERAZINE

N-(TERT-BUTOXYCARBONYL)HOMOPIPERAZINE

Boc-homopiperazine≥ 98% (Assay by titration)

Boc-HomoPiz

BOC-HOMOPIPERAZINE

BOC-HOPIZ

BOC-HOPAZ

BUTTPARK 27\08-71

HPBOC

1-(TERT-BUTOXYCARBONYL)HOMOPIPERAZINE

N-(TERT-BUTYLOXYCARBONYL)-HOMOPIPERAZINE

1-(tert-Butoxycarbonyl)homopiperazine~tert-Butyl hexahydro-1,4-diazepine-1-carboxylate

Tert-butylhexahydro-1,4-diazepine-1-carboxylate

N-TERT-BUTYL-1-HOMOPIPERAZINE CARBOXYLATE

1-BOC-HOMOPIPERAZINE 98%

Boc-HoPaz*HCl

N-(t-Butyloxycarbonyl)-homopiperazine hydrochloride

Boc-HoPiz, liq.

1-Boc-homopiperazine, tert-Butyl homopiperazine-1-carboxylate

N-Butoxycarbonylhomopiperazine

1-Boc-homopiperazine ,98%

tert-butyl 1,4-diazocane-1-carboxylate

1-(tert-Butoxycarbonyl)homopiperazine, tert-Butyl 1,4-diazepane-1-carboxylate

1-BOC-hexahydro-1,4-diazepine, 98% 5GR

1,4-Diazepane, N1-BOC protected

1-Boc-hexahydro-1,4-diazepine 98%

Homopiperazine, N1-BOC protected 97%

1H-1,4-Diazepine-1-carboxylic acid, hexahydro-, 1,1-dimethylethyl ester

1-(tert-Butoxycarbonyl)-1,4-diazacycloheptane

112275-50-0---1-Boc-hexahydro-1,4-diazepine

112275-50-0

Building Blocks

Piperazines

Heterocyclic Building Blocks

API intermediates

Piperidines, Piperidones, Piperazines

Heterocycles series

Piperaizine