6-Quinolinylmethanol
- Product Name
- 6-Quinolinylmethanol
- CAS No.
- 100516-88-9
- Chemical Name
- 6-Quinolinylmethanol
- Synonyms
- CC 04509;ZINC01436222;6-quinolylmethanol;6-quinolinemethanol;4-cinnolinemethanol;RARECHEM AK ML 0560;6-QUINOLINYLMETHANOL;Quinoline-6-methanol;quinolin-6-ylmethanol;SDCCGMLS-0065932.P001
- CBNumber
- CB2124355
- Molecular Formula
- C10H9NO
- Formula Weight
- 159.18
- MOL File
- 100516-88-9.mol
6-Quinolinylmethanol Property
- Melting point:
- 79-80 ºC
- Boiling point:
- 334.8±17.0 °C(Predicted)
- Density
- 1.218±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- 14.02±0.10(Predicted)
- Appearance
- Light brown to yellow Solid
- CAS DataBase Reference
- 100516-88-9
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 6-24/25-26-36/37/39
- HazardClass
- IRRITANT
- HS Code
- 29334900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
H412Harmful to aquatic life with long lasting effects
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- Q990040
- Product name
- 6-Quinolinylmethanol
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- OR346681
- Product name
- (Quinolin-6-yl)methanol
- Purity
- 95+%
- Packaging
- 1g
- Price
- $102
- Updated
- 2021/12/16
- Product number
- JK131061
- Product name
- 6-Quinolinylmethanol
- Purity
- 97%
- Packaging
- 250mg
- Price
- $141
- Updated
- 2021/12/16
- Product number
- 062389
- Product name
- Quinolin-6-ylmethanol
- Packaging
- 500mg
- Price
- $237
- Updated
- 2021/12/16
- Product number
- JK131061
- Product name
- 6-Quinolinylmethanol
- Purity
- 97%
- Packaging
- 1g
- Price
- $465
- Updated
- 2021/12/16
6-Quinolinylmethanol Chemical Properties,Usage,Production
Chemical Properties
Light yellow or pink powder
Synthesis
38896-30-9
100516-88-9
General procedure for the synthesis of 6-hydroxymethylquinoline from methyl 6-quinolinecarboxylate: cooling of a 0.2 M solution of methyl 6-quinolinecarboxylate (0.300 g, 1.60 mmol) in THF (8 mL) and a 0.6 M solution of diisobutylaluminum hydride (DIBAL) (0.860 mL, 4.81 mmol) in THF in an acetone-dry ice bath at -78 °C ( 8mL). The DIBAL solution was transferred to the methyl ester solution via cannula and the resulting solution was stirred for 1 h at 0 °C. The reaction was quenched by the addition of methanol (8 mL) and acetic acid (1.37 mL, 24.0 mmol) at 0 °C. After stirring for 5 min, saturated sodium tartrate solution (16 mL) was added. Stirring was continued for 20 min, followed by dilution of the reaction mixture with EtOAc (50 mL) and water (10 mL). The aqueous layer was extracted with EtOAc (3 x 50 mL). The organic phases were combined and washed once with 15 mL of water. The organic layer was dried with Na2SO4, filtered and concentrated under reduced pressure. Purification by column chromatography (50-90% EtOAc/hexane) afforded 0.236 g (93%) of 6-hydroxymethylquinoline (S3a) as a pale yellow oil.1H NMR (500 MHz, CDCl3): δ 4.89 (s, 2H), 7.35 (dd, 1H, J=4.0,8.0), 7.65 (dd, 1H, J=1.5, 9.0), 7.77 (s, 1H), 8.01 (d, 1H, J=9.0), 8.08 (d, 1H, J=4.0), 8.80 (dd, 1H, J=1.5,4.0).13C-NMR (125MHz, CDCl3): δ64.8,121.5,125.0,128.3,129.0,129.4. 136.4,139.9,147.7,150.2. HRMS-FAB (m/z): calculated value for [MH]+ C10H10NO, 160.0762; measured value: 160.0766.
References
[1] Journal of the American Chemical Society, 2008, vol. 130, # 20, p. 6404 - 6410
[2] Patent: WO2009/75778, 2009, A2. Location in patent: Page/Page column 49-50
[3] Patent: WO2004/7491, 2004, A1. Location in patent: Page 55-56
[4] Patent: WO2017/40449, 2017, A1. Location in patent: Paragraph 00363
[5] Patent: WO2011/18454, 2011, A1. Location in patent: Page/Page column 56
6-Quinolinylmethanol Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6-Quinolinylmethanol manufacturers
- Product
- 6-Quinolinylmethanol 100516-88-9
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2018-12-22