ChemicalBook > CAS DataBase List > 4-methylquinoline

4-methylquinoline

Product Name
4-methylquinoline
CAS No.
491-35-0
Chemical Name
4-methylquinoline
Synonyms
4-METHYLQUINOLINE;4-Lepidine;4-METHYLCHINOLINE;Lepidin;epidine;LEPIDINE;Lepidine>Lepidine,98%;Lepidine ,99%;4-Methylchinol
CBNumber
CB8121295
Molecular Formula
C10H9N
Formula Weight
143.19
MOL File
491-35-0.mol
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4-methylquinoline Property

Melting point:
9-10 °C(lit.)
Boiling point:
261-263 °C(lit.)
Density 
1.083 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.620(lit.)
Flash point:
>230 °F
storage temp. 
Refrigerator
solubility 
Chloroform (Slightly), Methanol (Slightly)
pka
5.67(at 20℃)
form 
Liquid
color 
Pale Orange
Odor
at 100.00 %. burnt oily herbal floral sweet
Odor Type
burnt
Water Solubility 
Slightly soluble
Sensitive 
Light Sensitive
Merck 
14,5441
BRN 
110926
InChIKey
MUDSDYNRBDKLGK-UHFFFAOYSA-N
LogP
2.610
CAS DataBase Reference
491-35-0(CAS DataBase Reference)
NIST Chemistry Reference
Quinoline, 4-methyl-(491-35-0)
EPA Substance Registry System
Quinoline, 4-methyl- (491-35-0)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-68-40
Safety Statements 
26-36-45-36/37/39-22
WGK Germany 
3
RTECS 
OH0316000
8-10
TSCA 
Yes
HS Code 
29334900
Hazardous Substances Data
491-35-0(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
158283
Product name
Lepidine
Purity
99%
Packaging
25g
Price
$99.3
Updated
2024/03/01
Sigma-Aldrich
Product number
158283
Product name
Lepidine
Purity
99%
Packaging
100g
Price
$188
Updated
2024/03/01
TCI Chemical
Product number
L0024
Product name
Lepidine
Purity
>97.0%(GC)(T)
Packaging
25mL
Price
$59
Updated
2024/03/01
TCI Chemical
Product number
L0024
Product name
Lepidine
Purity
>97.0%(GC)(T)
Packaging
100mL
Price
$165
Updated
2024/03/01
Alfa Aesar
Product number
A14040
Product name
Lepidine, 97%
Packaging
10g
Price
$45.65
Updated
2024/03/01
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4-methylquinoline Chemical Properties,Usage,Production

Description

Refer to 6-METHYLQUINOLINE.

Chemical Properties

clear slightly yellow to brown liquid

Physical properties

4-Methylquinoline is a colorless liquid with a weak quinoline-like odor. It is slightly soluble in water, miscible with many organic solvents, and volatile in steam.

Uses

Lepidine is used in the preparation of certain dyes.

Uses

4-Methylquinoline is used as a reagent in the synthesis of azetidine based ene-amides as potent bacterial enoyl ACP reductase inhibitors. Also used as a reagent in the synthesis of cyanine-styryl dyes with enhanced photostability for fluorescent DNA imaging.

Production Methods

4-Methylquinoline can be recovered from the highest-boiling fraction of the coal-tar quinoline bases via its o-cresol addition compound. It can be synthesized by condensation of aniline and methyl vinyl ketone.

Definition

ChEBI: A methylquinoline carrying a methyl substituent at position 4.

Synthesis Reference(s)

Tetrahedron Letters, 28, p. 5291, 1987 DOI: 10.1016/S0040-4039(00)96710-8

General Description

Synthesis of lepidine from 4-anilinobutan-2-one in ethanol in the presence of HCl or FeCl3 has been reported. Nitration of lepidine has been reported.

Purification Methods

Reflux lepidine with BaO, then fractionally distil it. Further purify it via its recrystallised dichromate salt (m 138o) (from H2O). [Cumper et al. J Chem Soc 1176 1962.] [Beilstein 20 III/IV 3477, 20/7 V 389.]

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4-methylquinoline Suppliers

Wuhan EnTai Technology Development Co,.Ltd
Tel
86-27-82330560
Fax
86-27-82330547
Email
2536851935@qq.com
Country
China
ProdList
348
Advantage
69
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006608290; 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40241
Advantage
62
INTATRADE GmbH
Tel
+49 3493/605464
Fax
+49 3493/605470
Email
sales@intatrade.de
Country
Germany
ProdList
3576
Advantage
66
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30132
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24539
Advantage
81
Beijing dtftchem Technology Co., Ltd.
Tel
010-60275820 13031183356
Fax
010-60270825
Email
elainezt@sina.com
Country
China
ProdList
1392
Advantage
62
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44751
Advantage
61
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9555
Advantage
66
Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
Fax
001-617-206-9595
Email
sales@chemreagents.com
Country
United States
ProdList
10194
Advantage
62
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696;
Email
info@hanhongsci.com
Country
China
ProdList
42982
Advantage
64
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View Lastest Price from 4-methylquinoline manufacturers

Hebei Mojin Biotechnology Co., Ltd
Product
4-methylquinoline 491-35-0
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-08-25
Hebei Guanlang Biotechnology Co., Ltd.
Product
Lepidine 491-35-0
Price
US $10.00/PCS
Min. Order
1KG
Purity
99%
Supply Ability
100 mt
Release date
2021-04-12
Shaanxi Dideu Medichem Co. Ltd
Product
Lepidine 491-35-0
Price
US $0.10/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
1000 tons
Release date
2020-04-28

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