4-Quinolinecarboxaldehyde

Product Name: 4-Quinolinecarboxaldehyde
CAS No.: 4363-93-3
Chemical Name: 4-Quinolinecarboxaldehyde
Synonyms: QUINOLINE-4-CARBALDEHYDE;4-fomylquinoline;4-FORMYLQUINOLINE;AKOS BBS-00005334;CINCHONINALDEHYDE;TIMTEC-BB SBB004008;RARECHEM AQ NN 0218;4-Quinolinealdehyde;QUINOLINE-4-ALDEHYDE;4-QUINOLINECARBALDEHYDE
CBNumber: CB4773795
Molecular Formula: C10H7NO
Formula Weight: 157.17
MOL File: 4363-93-3.mol

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4-Quinolinecarboxaldehyde Property

Melting point:: 45-52 °C (lit.)
Boiling point:: 131-133°C 5mm
Density: 1.1599 (rough estimate)
refractive index: 1.5000 (estimate)
Flash point:: >230 °F
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
pka: 2.95±0.13(Predicted)
form: Crystalline Powder, Chunks, or Solid
color: Off-white to yellow-brown
Water Solubility: Slightly soluble in water.
Sensitive: Air Sensitive
BRN: 113072
InChI: InChI=1S/C10H7NO/c12-7-8-5-6-11-10-4-2-1-3-9(8)10/h1-7H
InChIKey: MGCGJBXTNWUHQE-UHFFFAOYSA-N
SMILES: N1C2C(=CC=CC=2)C(C=O)=CC=1
CAS DataBase Reference: 4363-93-3(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 37/38-36/37/38
Safety Statements: 24/25-36-26-36/37/39
WGK Germany: 3
F: 10
HazardClass: IRRITANT
HS Code: 29334900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 176966
Product name: 4-Quinolinecarboxaldehyde
Purity: 97%
Packaging: 2.5g
Price: $75.3
Updated: 2025/07/31

Sigma-Aldrich

Product number: 176966
Product name: 4-Quinolinecarboxaldehyde
Purity: 97%
Packaging: 10g
Price: $246
Updated: 2025/07/31

TCI Chemical

Product number: Q0061
Product name: 4-Quinolinecarboxaldehyde
Purity: >97.0%(GC)(T)
Packaging: 1g
Price: $38
Updated: 2025/07/31

TCI Chemical

Product number: Q0061
Product name: 4-Quinolinecarboxaldehyde
Purity: >97.0%(GC)(T)
Packaging: 5g
Price: $103
Updated: 2025/07/31

TCI Chemical

Product number: Q0061
Product name: 4-Quinolinecarboxaldehyde
Purity: >97.0%(GC)(T)
Packaging: 25g
Price: $348
Updated: 2025/07/31

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4-Quinolinecarboxaldehyde Chemical Properties,Usage,Production

Chemical Properties

yellow to yellow-brown crystalline powder

Occurrence

The common presence of 4-quinolinecarboxaldehyde in honey from Galicia (northwest of Spain). As opposed to other quinoline carboxylic acid derivatives, the 4- quinolinecarboxaldehyde species has not been correlated with the anti-diabetic properties of honey; nevertheless, it appears to be active against intestinal bacteria.

Uses

4-Quinolinecarboxaldehyde was used in the synthesis of lepidylamines. It also shows antimicrobial activity toward human intestinal bacteria such as Clostridium perfringens.

Synthesis Reference(s)

The Journal of Organic Chemistry, 35, p. 841, 1970 DOI: 10.1021/jo00828a074

Synthesis

491-35-0

4363-93-3

The general procedure for the synthesis of 4-quinolinecarboxaldehyde from 4-methylquinoline was as follows: 5.0 g (35 mmol) of 4-methylquinoline and 5.0 g (45 mmol) of selenium dioxide were dissolved in toluene under argon protection and heated to reflux for 24 hours. After completion of the reaction, the reaction mixture was diluted with dichloromethane, washed sequentially with saturated saline and dried with anhydrous magnesium sulfate. After concentration under reduced pressure, the reaction was purified by silica gel column chromatography using a solvent mixture of hexane and ethyl acetate (4:1, v/v) as eluent to give 4.0 g (73% yield) of the target product 4-quinolinecarboxaldehyde as a solid. Nuclear magnetic resonance hydrogen spectroscopy (1H NMR) data: δ 10.54 (s, 1H), 9.22 (d, J = 4.3 Hz, 1H), 9.04 (d, J = 8.6 Hz, 1H), 8.24 (d, J = 8.2 Hz, 1H), 7.84 (t, J = 7.6 Hz, 1H), 7.81 (d, J = 4.3 Hz, 1H), 7.76 (t , J = 8.0 Hz, 1H). Nuclear magnetic resonance carbon (13C NMR) data: δ 193.1, 150.7, 149.5, 137.0, 130.4, 130.3, 129.6, 126.0, 124.7, 124.1. mass spectrometry (electrospray ionization) data: m/z 158.0 (100%) ([M + H]+), 130.2.

References

[1] Tamara Rodríguez-Cabo. “Time-of-flight accurate mass spectrometry identification of quinoline alkaloids in honey.” Analytical and Bioanalytical Chemistry 407 20 (2015): 6159–6170.

4-Quinolinecarboxaldehyde Preparation Products And Raw materials

Raw materials

Ethanol Acetone Formaldehyde Zinc chloride 1,4-Dioxane Iron chloride hexahydrate 4-METHOXY-2-BUTANONE Aniline Ethyl acetate Hydrochloric acid Methyl vinyl ketone Sodium hydroxide 4-methylquinoline Selenium dioxide PETROLEUM ETHER Sodium carbonate

Preparation Products

4-Aminomethylquinoline hydrochloride

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4-Quinolinecarboxaldehyde Suppliers

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View Lastest Price from 4-Quinolinecarboxaldehyde manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 4-Quinolinecarboxaldehyde 4363-93-3
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2025-06-03

Zhuozhou Wenxi import and Export Co., Ltd

Product: 4-Quinolinecarbaldehyde 4363-93-3
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-08

Career Henan Chemical Co

Product: 4-Quinolinecarboxaldehyde 4363-93-3
Price: US $1.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 100KG
Release date: 2018-12-22

4363-93-3, 4-QuinolinecarboxaldehydeRelated Search:

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