ChemicalBook > CAS DataBase List > 4-Quinolinecarboxaldehyde

4-Quinolinecarboxaldehyde

Product Name
4-Quinolinecarboxaldehyde
CAS No.
4363-93-3
Chemical Name
4-Quinolinecarboxaldehyde
Synonyms
QUINOLINE-4-CARBALDEHYDE;4-fomylquinoline;4-FORMYLQUINOLINE;AKOS BBS-00005334;CINCHONINALDEHYDE;TIMTEC-BB SBB004008;RARECHEM AQ NN 0218;4-Quinolinealdehyde;QUINOLINE-4-ALDEHYDE;4-QUINOLINECARBALDEHYDE
CBNumber
CB4773795
Molecular Formula
C10H7NO
Formula Weight
157.17
MOL File
4363-93-3.mol
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4-Quinolinecarboxaldehyde Property

Melting point:
45-52 °C (lit.)
Boiling point:
131-133°C 5mm
Density 
1.1599 (rough estimate)
refractive index 
1.5000 (estimate)
Flash point:
>230 °F
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
pka
2.95±0.13(Predicted)
form 
Crystalline Powder, Chunks, or Solid
color 
Off-white to yellow-brown
Water Solubility 
Slightly soluble in water.
Sensitive 
Air Sensitive
BRN 
113072
InChI
InChI=1S/C10H7NO/c12-7-8-5-6-11-10-4-2-1-3-9(8)10/h1-7H
InChIKey
MGCGJBXTNWUHQE-UHFFFAOYSA-N
SMILES
N1C2C(=CC=CC=2)C(C=O)=CC=1
CAS DataBase Reference
4363-93-3(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
37/38-36/37/38
Safety Statements 
24/25-36-26-36/37/39
WGK Germany 
3
F 
10
HazardClass 
IRRITANT
HS Code 
29334900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
176966
Product name
4-Quinolinecarboxaldehyde
Purity
97%
Packaging
2.5g
Price
$75.3
Updated
2025/07/31
Sigma-Aldrich
Product number
176966
Product name
4-Quinolinecarboxaldehyde
Purity
97%
Packaging
10g
Price
$246
Updated
2025/07/31
TCI Chemical
Product number
Q0061
Product name
4-Quinolinecarboxaldehyde
Purity
>97.0%(GC)(T)
Packaging
1g
Price
$38
Updated
2025/07/31
TCI Chemical
Product number
Q0061
Product name
4-Quinolinecarboxaldehyde
Purity
>97.0%(GC)(T)
Packaging
5g
Price
$103
Updated
2025/07/31
TCI Chemical
Product number
Q0061
Product name
4-Quinolinecarboxaldehyde
Purity
>97.0%(GC)(T)
Packaging
25g
Price
$348
Updated
2025/07/31
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4-Quinolinecarboxaldehyde Chemical Properties,Usage,Production

Chemical Properties

yellow to yellow-brown crystalline powder

Occurrence

The common presence of 4-quinolinecarboxaldehyde in honey from Galicia (northwest of Spain). As opposed to other quinoline carboxylic acid derivatives, the 4- quinolinecarboxaldehyde species has not been correlated with the anti-diabetic properties of honey; nevertheless, it appears to be active against intestinal bacteria.

Uses

4-Quinolinecarboxaldehyde was used in the synthesis of lepidylamines. It also shows antimicrobial activity toward human intestinal bacteria such as Clostridium perfringens.

Synthesis Reference(s)

The Journal of Organic Chemistry, 35, p. 841, 1970 DOI: 10.1021/jo00828a074

Synthesis

491-35-0

4363-93-3

The general procedure for the synthesis of 4-quinolinecarboxaldehyde from 4-methylquinoline was as follows: 5.0 g (35 mmol) of 4-methylquinoline and 5.0 g (45 mmol) of selenium dioxide were dissolved in toluene under argon protection and heated to reflux for 24 hours. After completion of the reaction, the reaction mixture was diluted with dichloromethane, washed sequentially with saturated saline and dried with anhydrous magnesium sulfate. After concentration under reduced pressure, the reaction was purified by silica gel column chromatography using a solvent mixture of hexane and ethyl acetate (4:1, v/v) as eluent to give 4.0 g (73% yield) of the target product 4-quinolinecarboxaldehyde as a solid. Nuclear magnetic resonance hydrogen spectroscopy (1H NMR) data: δ 10.54 (s, 1H), 9.22 (d, J = 4.3 Hz, 1H), 9.04 (d, J = 8.6 Hz, 1H), 8.24 (d, J = 8.2 Hz, 1H), 7.84 (t, J = 7.6 Hz, 1H), 7.81 (d, J = 4.3 Hz, 1H), 7.76 (t , J = 8.0 Hz, 1H). Nuclear magnetic resonance carbon (13C NMR) data: δ 193.1, 150.7, 149.5, 137.0, 130.4, 130.3, 129.6, 126.0, 124.7, 124.1. mass spectrometry (electrospray ionization) data: m/z 158.0 (100%) ([M + H]+), 130.2.

References

[1] Tamara Rodríguez-Cabo. “Time-of-flight accurate mass spectrometry identification of quinoline alkaloids in honey.” Analytical and Bioanalytical Chemistry 407 20 (2015): 6159–6170.

4-Quinolinecarboxaldehyde Preparation Products And Raw materials

Raw materials

Ethanol Acetone Formaldehyde Zinc chloride 1,4-Dioxane Iron chloride hexahydrate 4-METHOXY-2-BUTANONE Aniline Ethyl acetate Hydrochloric acid Methyl vinyl ketone Sodium hydroxide 4-methylquinoline Selenium dioxide PETROLEUM ETHER Sodium carbonate

Preparation Products

4-Aminomethylquinoline hydrochloride
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View Lastest Price from 4-Quinolinecarboxaldehyde manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
4-Quinolinecarboxaldehyde 4363-93-3
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
10000KGS
Release date
2025-06-03
Zhuozhou Wenxi import and Export Co., Ltd
Product
4-Quinolinecarbaldehyde 4363-93-3
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-08
Career Henan Chemical Co
Product
4-Quinolinecarboxaldehyde 4363-93-3
Price
US $1.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
100KG
Release date
2018-12-22

4363-93-3, 4-QuinolinecarboxaldehydeRelated Search:

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