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N-Acetylsulfanilyl chloride

Product Name
N-Acetylsulfanilyl chloride
CAS No.
121-60-8
Chemical Name
N-Acetylsulfanilyl chloride
Synonyms
ASC;NASC;CARD5;NSC 127860;dagenanchloride;acetylsulfanilyl;Dagenan chloride;N-Acetylsulfanilyl;N-Acetylsulfanilyl c;acetylsulfanilylchloride
CBNumber
CB4452614
Molecular Formula
C8H8ClNO3S
Formula Weight
233.67
MOL File
121-60-8.mol
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N-Acetylsulfanilyl chloride Property

Melting point:
142-145 °C (dec.)(lit.)
Boiling point:
426.8±28.0 °C(Predicted)
Density 
1.2977 (rough estimate)
refractive index 
1.6300 (estimate)
storage temp. 
-20°C
pka
13.75±0.70(Predicted)
form 
Granular Crystalline Powder or Crystals
color 
White to cream-beige
Water Solubility 
SLIGHTLY SOLUBLE
Sensitive 
Moisture Sensitive
Merck 
14,103
BRN 
746676
CAS DataBase Reference
121-60-8(CAS DataBase Reference)
NIST Chemistry Reference
P-acetamidobenzene sulfonyl chloride(121-60-8)
EPA Substance Registry System
Benzenesulfonyl chloride, 4-(acetylamino)- (121-60-8)
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Safety

Hazard Codes 
C
Risk Statements 
22-34-37
Safety Statements 
26-36/37/39-45-28B
RIDADR 
UN 3261 8/PG 2
WGK Germany 
3
RTECS 
DB8837500
9-21
TSCA 
Yes
HazardClass 
8
PackingGroup 
II
HS Code 
29242995
Hazardous Substances Data
121-60-8(Hazardous Substances Data)
Toxicity
LD50 oral in rat: > 3200mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H290May be corrosive to metals

H314Causes severe skin burns and eye damage

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P234Keep only in original container.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P310Immediately call a POISON CENTER or doctor/physician.

P390Absorb spillage to prevent material damage.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

P406Store in corrosive resistant/… container with a resistant inner liner.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
112747
Product name
N-Acetylsulfanilyl chloride
Purity
98%
Packaging
100g
Price
$46.8
Updated
2020/08/18
Sigma-Aldrich
Product number
112747
Product name
N-Acetylsulfanilyl chloride
Purity
98%
Packaging
1kg
Price
$135
Updated
2020/08/18
TCI Chemical
Product number
A0074
Product name
4-Acetamidobenzenesulfonyl Chloride
Purity
>98.0%(HPLC)(T)
Packaging
25g
Price
$76
Updated
2020/06/24
TCI Chemical
Product number
A0074
Product name
4-Acetamidobenzenesulfonyl Chloride
Purity
>98.0%(HPLC)(T)
Packaging
100g
Price
$220
Updated
2020/06/24
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N-Acetylsulfanilyl chloride Chemical Properties,Usage,Production

Chemical Properties

OFF-WHITE TO SLIGHTLY GREY GRANULAR CRYST. POWDER

Uses

A sulfanilamide derivative of Chitosan

Uses

Intermediate in the preparation of sulfanilamide and its derivatives.

Biotechnological Production

After more than three decades of strain and process optimization, the 2KGA fermentation by K. vulgare has reached a performance level that makes it increasingly difficult to achieve further cost-relevant improvements. Instead, opportunities can be seen in the succeeding step of 2KGA rearrangement to ascorbic acid, which still follows the same concept as laid out in the 1930s by Reichstein and Grüssner. This chemical step contributes significantly to the overall process costs. A process Industrial Production of L-Ascorbic Acid (Vitamin C) and D-Isoascorbic Acid 171 concept that could convert sorbitol directly to ascorbic acid would therefore be most attractive. In theory, this could build on the established 2KGA fermentation with an enzyme-catalyzed 2KGA to Asc rearrangement (2,6-hemiacetal to 1,4- lactone) as extension. Ab initio energy calculations as well as experimental results (own unpublished results) indicate that in aqueous environment, Asc is thermodynamically far more stable than 2KGA and (nearly) quantitative conversion should be possible. However, no enzyme efficiently catalyzing this reaction has so far been identified. The few publications of enzyme catalysis for this reaction so far shows only trace activity and no significant improvements have been reported. 2KGA may represent a kinetic trap in an aqueous environment and biotechnological reaction pathways all the way to Asc may need to avoid 2KGA. Accordingly, 2KGA is also not part of natural biosynthetic routes, where Asc formation directly results from the oxidation of precursor molecules with appropriately preformed 1,4-lactone linkage (L-gulono-1,4-lactone in animals, L-galactono-1,4-lactone in plants). Enzymes converting L-gulono-1,4-lactone to Asc are also known from bacteria, even from Ketogulonicigenium. The biochemical description of the Ketogulonicigenium enzyme indicates that it belongs to the family of heterotrimeric periplasmic flavohemoproteins, of which several can be found in the published Ketogulonicigenium genomes. Besides sharing the same FAD cofactor, these enzymes bear no similarity to the mammalian gulono-1,4- lactone dehydrogenase. The use of these natural or nature-like Asc-forming enzymatic steps in biotechnological production processes is so far precluded by the rare nature of these L-sugar-derived lactone precursor molecules and the lack of efficient production methods for these compounds. It was, therefore, a tantalizing discovery when Asc formation directly from L-sorbosone, the intermediate of the efficient 2KGA formation route, was identified in those two species already in the focus for 2KGA production for decades: K. vulgare and G. oxydans. Besides an earlier report of L-sorbosone to Asc activity derived from plant tissue , which did not see consolidating follow-ups, the above observations are the first evidence of biological Asc formation from a molecule other than a 1,4-lactone.

Safety Profile

A poison by intraperitoneal route.Moderately toxic by ingestion. When heated todecomposition it emits toxic vapors of NOx, SOx, and Cl.

Purification Methods

Crystallise the chloride from toluene, CHCl3, or ethylene dichloride. [Beilstein 14 IV 2703.]

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N-Acetylsulfanilyl chloride Suppliers

Creasyn Finechem(Tianjin) Co., Ltd.
Tel
022-83945878-
Fax
022-83945176
Email
export@creasyn.com
Country
China
ProdList
696
Advantage
68
Shanghai Boyle Chemical Co., Ltd.
Tel
Mr Qiu:021-50182298(Demestic market) Miss Xu:021-50180596(Abroad market)
Fax
+86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2214
Advantage
55
J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Fax
86-10-82849933
Email
jkinfo@jkchemical.com;market6@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
21-61259100-
Fax
86-21-61259102
Email
sh@meryer.com
Country
China
ProdList
40268
Advantage
62
Alfa Aesar
Tel
400-610-6006; 021-67582000
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30163
Advantage
84
TAIYUAN RHF CO.,LTD.
Tel
+86 351 7031519
Fax
+86 351 7031519
Email
sales@RHFChem.com
Country
China
ProdList
2347
Advantage
56
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386 / 800-988-0390
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24555
Advantage
81
Beijing dtftchem Technology Co., Ltd.
Tel
13651141086; 86(10)60275028、60275820
Fax
86 (10) 60270825
Email
dtftchem@sina.com
Country
China
ProdList
3393
Advantage
62
BeiJing Hwrk Chemicals Limted
Tel
0757-86311057-
Fax
0757-86311057
Email
kennyrong@hwrkchemical.com
Country
China
ProdList
18708
Advantage
55
Energy Chemical
Tel
021-58432009
Fax
021-58436166-800
Email
sales8178@energy-chemical.com
Country
China
ProdList
44026
Advantage
61
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View Lastest Price from N-Acetylsulfanilyl chloride manufacturers

Hebei Runbin Biotechnology Co. LTD
Product
N-Acetylsulfanilyl chloride 121-60-8
Price
US $195.00/KG
Min. Order
1KG
Purity
99%min
Supply Ability
1000 Kilogram/Kilograms per Month
Release date
2020-08-27
Shaanxi Dideu Medichem Co. Ltd
Product
N-Acetylsulfanilyl chloride 121-60-8
Price
US $0.10/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
1000 tons
Release date
2020-01-07
career henan chemical co
Product
ASCORBATE OXIDASE 121-60-8
Price
US $1.00/kg
Min. Order
1kg
Purity
95%-99%
Supply Ability
100kg
Release date
2018-12-24

121-60-8, N-Acetylsulfanilyl chlorideRelated Search:


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