ChemicalBook > CAS DataBase List > 4-Nitrobenzenesulfonyl chloride

4-Nitrobenzenesulfonyl chloride

Product Name
4-Nitrobenzenesulfonyl chloride
CAS No.
98-74-8
Chemical Name
4-Nitrobenzenesulfonyl chloride
Synonyms
NsCl;4-NITROBENZENE-1-SULFONYL CHLORIDE;P-NITROBENZENESULFONYL CHLORIDE;p-Nitrophenylsulfonyl chloride;Nosylchloride;4-NitrobenzenesuL;4-Nitrobenzenesulfon;nosyl ch202-697-9loride;4-Nitrophenylsulfonylchloride;4-Nitrophenylsulfonyl chloride
CBNumber
CB7298161
Molecular Formula
C6H4ClNO4S
Formula Weight
221.62
MOL File
98-74-8.mol
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4-Nitrobenzenesulfonyl chloride Property

Melting point:
75 °C
Boiling point:
143-144 °C (1.5002 mmHg)
Density 
1.602 (estimate)
vapor pressure 
0.009Pa at 20℃
refractive index 
1.6000 (estimate)
Flash point:
143-144°C/1.5mm
storage temp. 
Store below +30°C.
solubility 
soluble in Toluene
form 
Powder
color 
yellow
PH
1 (H2O, 20℃)
Water Solubility 
Insoluble
Sensitive 
Moisture Sensitive
BRN 
746543
Stability:
Moisture Sensitive
LogP
2.1 at 20℃
CAS DataBase Reference
98-74-8(CAS DataBase Reference)
NIST Chemistry Reference
4-Nitrobenzenesulphonyl chloride(98-74-8)
EPA Substance Registry System
Benzenesulfonyl chloride, 4-nitro- (98-74-8)
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Safety

Hazard Codes 
C
Risk Statements 
34-52/53
Safety Statements 
26-36/37/39-45-61
RIDADR 
UN 3261 8/PG 2
WGK Germany 
3
F 
21
Hazard Note 
Corrosive/Moisture Sensitive
TSCA 
Yes
HazardClass 
8
PackingGroup 
II
HS Code 
29049085
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H317May cause an allergic skin reaction

H318Causes serious eye damage

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
272248
Product name
4-Nitrobenzenesulfonyl chloride
Purity
97%
Packaging
5g
Price
$36.4
Updated
2024/03/01
Sigma-Aldrich
Product number
170925
Product name
4-Nitrobenzenesulfonyl chloride
Purity
technical grade, 90%
Packaging
25g
Price
$33.78
Updated
2024/03/01
TCI Chemical
Product number
N0144
Product name
4-Nitrobenzenesulfonyl Chloride
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$16
Updated
2024/03/01
TCI Chemical
Product number
N0144
Product name
4-Nitrobenzenesulfonyl Chloride
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$43
Updated
2024/03/01
Alfa Aesar
Product number
A18512
Product name
4-Nitrobenzenesulfonyl chloride, 97%
Packaging
25g
Price
$71.5
Updated
2024/03/01
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4-Nitrobenzenesulfonyl chloride Chemical Properties,Usage,Production

Chemical Properties

yellow to brown powder

Uses

4-Nitrobenzenesulfonyl chloride is used as an intermediate for the synthesis of pharmaceuticals like foscmprenavir, darunavir and amprenavir. It is involved in the preparation of N-nosyl-alpha-amino acid for peptide synthesis. It is also used for stereoselective α-glucosylation of partially protected carbohydrates in association with silver tri-fluoromethanesulfonate, N,N-dimethylacetamide and triethylamine. It is widely used for the synthesis of hydroxylamines of sulfadiazine, sulfamethoxazole and [Cu(bipy)2Cl](nbs) (1) (bipy = 2,2'-bipyridine, nbs = 4-nitrobenzenesulfonate).

Uses

4-Nitrobenzenesulfonyl chloride was used in the synthesis of

  • [Cu(bipy)2Cl](nbs) (1) (bipy = 2,2′-bipyridine, nbs = 4-nitrobenzenesulfonate)
  • hydroxylamines of sulfadiazine and sulfamethoxazole
  • solution phase peptide using N-nosyl-α-amino acids.

Uses

4-Nitrobenzenesulfonyl Chloride is used in the preparation of N-Nosyl-α-amino acid for peptide synthesis.

Production Methods

4,4'-Dinitrodiphenyldisulfide [100-32-3], produced by reaction of 4-chloronitrobenzene with sodium disulfide, is treated with chlorine in HCl – HNO3 by a process similar to that used for 2-nitrobenzenesulfonyl chloride.

Flammability and Explosibility

Not classified

4-Nitrobenzenesulfonyl chloride Preparation Products And Raw materials

Raw materials

DIPHENYL DISULFIDE Nitric acid

Preparation Products

4-Nitrobenzenesulfonamide 1-(4-NITROBENZENESULFONYL)-1H-1,2,4-TRIAZOLE Benazepril
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4-Nitrobenzenesulfonyl chloride Suppliers

Americas 1 China 134 Europe 1 India 20 Japan 1 United States 4 Global 161
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View Lastest Price from 4-Nitrobenzenesulfonyl chloride manufacturers

Henan Fengda Chemical Co., Ltd
Product
4-Nitrobenzenesulfonyl chloride 98-74-8
Price
US $100.00-1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2023-12-25
Firsky International Trade (Wuhan) Co., Ltd
Product
4-Nitrobenzenesulfonyl chloride 98-74-8
Price
US $30.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20T
Release date
2023-10-09
Wuhan wingroup Pharmaceutical Co., Ltd
Product
4-Nitrobenzenesulfonyl chloride 98-74-8
Price
US $30.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 Tons
Release date
2023-01-04

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