ChemicalBook > CAS DataBase List > 2-Methoxy-4-nitroaniline

2-Methoxy-4-nitroaniline

Product Name
2-Methoxy-4-nitroaniline
CAS No.
97-52-9
Chemical Name
2-Methoxy-4-nitroaniline
Synonyms
FAST RED B BASE;FAST RED B;RED B BASE;2-AMINO-5-NITROANISOLE;RED B ASE;METHOXY-4-NITROANILINE;4-NITRO-ORTHO-ANISIDINE;AZOIC DIAZO COMPONENT 5;4-NITRO-2-METHOXYANILINE;2-Methoxy-4-nitrobenzenamine
CBNumber
CB1693973
Molecular Formula
C7H8N2O3
Formula Weight
168.15
MOL File
97-52-9.mol
More
Less

2-Methoxy-4-nitroaniline Property

Melting point:
140-142 °C(lit.)
Boiling point:
337.07°C (rough estimate)
Density 
1,211 g/cm3
refractive index 
1.6010 (estimate)
storage temp. 
Store below +30°C.
solubility 
0.2g/l
form 
Crystalline Powder
pka
1.02±0.10(Predicted)
color 
Yellow to orange
PH
6.2 (0.2g/l, H2O, 20℃)
Water Solubility 
slightly soluble
BRN 
879619
InChIKey
GVBHRNIWBGTNQA-UHFFFAOYSA-N
CAS DataBase Reference
97-52-9(CAS DataBase Reference)
NIST Chemistry Reference
Benzenamine, 2-methoxy-4-nitro-(97-52-9)
EPA Substance Registry System
2-Methoxy-4-nitroaniline (97-52-9)
More
Less

Safety

Hazard Codes 
Xn,Xi
Risk Statements 
22-36/37/38-20/21/22
Safety Statements 
26-37/39-36/37
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
2
RTECS 
BZ7170000
Hazard Note 
Irritant
TSCA 
Yes
HS Code 
29222900
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H351Suspected of causing cancer

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P308+P313IF exposed or concerned: Get medical advice/attention.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
112631
Product name
2-Methoxy-4-nitroaniline
Purity
98%
Packaging
100g
Price
$60.2
Updated
2024/03/01
TCI Chemical
Product number
M0118
Product name
2-Methoxy-4-nitroaniline
Purity
>99.0%(GC)
Packaging
25g
Price
$18
Updated
2024/03/01
TCI Chemical
Product number
M0118
Product name
2-Methoxy-4-nitroaniline
Purity
>99.0%(GC)
Packaging
500g
Price
$193
Updated
2024/03/01
Alfa Aesar
Product number
B24220
Product name
2-Methoxy-4-nitroaniline, 99%
Packaging
25g
Price
$18.65
Updated
2024/03/01
Alfa Aesar
Product number
B24220
Product name
2-Methoxy-4-nitroaniline, 99%
Packaging
100g
Price
$32.65
Updated
2024/03/01
More
Less

2-Methoxy-4-nitroaniline Chemical Properties,Usage,Production

Chemical Properties

2-Methoxy-4-nitroaniline is a yellow to orange crystalline powder. 2-Methoxy-4-nitroaniline (MONA) is a potential nonlinear optical (NLO) material, the N12–O19 bond length of MONA molecule is essentially controlled by the p-character of these hybrid orbitals and also by the nature of the N12–O19 bond. The molecular geometry of the compound is almost planar with the substituents[1].

Uses

2-Methoxy-4-nitroaniline is an important intermediate for preparing organic pigments and color bases of ice dyeing dyestuff. As a benzene dye intermediate, It is generally employed to prepare not only fast pigments but also as a printing and dyeing developer for cotton fabrics. In particular, 2-methoxy-4-nitroaniline is also important in production of some antineoplastic drugs[2-3].

Uses

2-Methoxy-4-nitroaniline is used as a photometric reagent for the determination of ethinylestradiol (ETE), a semi-synthetic estrogen that is widely used in oral contraceptives.

General Description

2-Methoxy-4-nitroaniline is an important inducer of CYP1A2 owing to its small molecular size.

Flammability and Explosibility

Non flammable

Biochem/physiol Actions

The metabolism of 2-methoxy-4-nitroaniline (MNA) occurs via the hydroxylation of the phenyl ring to form 6-hydroxy MNA in Harlan Sprague Dawley rats and B6C3F(1)/N mice.

Solubility in organics

The change trend of the solubility magnitude in different monosolvents from high to low was as follows: N-methylpyrrolidone (NMP) > dimethyl sulfoxide (DMSO) > 1,4-dioxane > ethyl acetate > acetonitrile > ethanol > methanol > n-propanol > isopropanol >  ethylene glycol (EG) > n-butanol > water[2].

References

[1] Bao Y, et al. 2-Methoxy-4-nitroaniline Solubility in Several Monosolvents: Measurement, Correlation, and Solvent Effect Analysis. Journal of Chemical & Engineering Data, 2020; 65: 757–765.
[2] Degawa M, et al.2-Methoxy-4-nitroaniline is a selective inducer of cytochrome P450IA2 (CYP1A2) in rat liver. Cancer Letters, 1995; 96: 95-98.
[3] Ravikumar C, et al. Electronic absorption and vibrational spectra and nonlinear optical properties of 4-methoxy-2-nitroaniline. Physical Chemistry Chemical Physics, 2010; 12: 9452-9460.

2-Methoxy-4-nitroaniline Preparation Products And Raw materials

Raw materials

o-Anisidine dilute sulphuric acid P-toluenesulfonyl chloride Nitrification Tosyl chloride PARA TOLUENE Nitric acid Acetic acid

Preparation Products

4-Fluoro-3-methoxyaniline C.I.Pigment Yellow 98 5-CHLORO-2-NITROANISOLE 8-METHOXYQUINOLIN-6-AMINE
More
Less

2-Methoxy-4-nitroaniline Suppliers

Americas 1 Belgium 1 China 197 Czech Republic 1 Europe 2 Germany 3 India 36 Indonesia 1 Japan 4 Slovakia 1 Switzerland 1 The Netherlands 1 Ukraine 2 United Kingdom 10 United States 29 Global 290
Xiangshui Henryda Tech Chemical Co., Ltd.
Tel
13771648447
Fax
+86-512-69233657
Email
sales@henryda-chem.com
Country
China
ProdList
61
Advantage
58
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40240
Advantage
62
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15848
Advantage
69
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30132
Advantage
84
TAIYUAN RHF CO.,LTD.
Tel
+86 351 7031519
Fax
+86 351 7031519
Email
sales@RHFChem.com
Country
China
ProdList
2341
Advantage
56
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24539
Advantage
81
ShangHai DEMO Chemical Co.,Ltd
Tel
400-021-7337 2355568890
Fax
0086-21-50182339
Email
sales@demochem.com
Country
China
ProdList
2572
Advantage
57
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44700
Advantage
61
Wuhan Chemwish Technology Co., Ltd
Tel
86-027-67849912
Fax
86-027-87531808
Email
sales@chemwish.com
Country
China
ProdList
35906
Advantage
56
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Email
sales@capotchem.com
Country
China
ProdList
18217
Advantage
66
Beijing Ouhe Technology Co., Ltd
Tel
010-82967028 13552068683
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12458
Advantage
60
Shanghai Sinch Parmaceuticals Tech. Co. Ltd.
Tel
+86-21-54098501
Fax
+86-21-54096319
Email
sales@sinch.com.cn
Country
China
ProdList
11605
Advantage
64
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9544
Advantage
66
BEST-REAGENT
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11726
Advantage
57
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400 638 7771
Email
sales@heowns.com
Country
China
ProdList
14443
Advantage
57
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
9823
Advantage
79
Maya High Purity Chemicals
Tel
+86 (573) 82222445 (0)18006601000 452520369
Fax
+86 (573) 82222643
Email
sales@maya-r.com
Country
China
ProdList
11714
Advantage
57
Chengdu Ai Keda Chemical Technology Co., Ltd.
Tel
4008-755-333 18080918076
Fax
028-86757656
Email
800078821@qq.com
Country
China
ProdList
9725
Advantage
55
Shanghai civi chemical technology co.,Ltd
Tel
86-21-34053660
Fax
86-21-34053661
Email
sale@labgogo.com
Country
China
ProdList
9872
Advantage
52
Thermo Fisher Scientific
Tel
800-810-5118
Fax
+86-10-84193589
Email
cnchemical@thermofisher.com
Country
China
ProdList
17779
Advantage
75
Beijing innoChem Science & Technology Co.,Ltd.
Tel
400-810-7969 010-59572699
Fax
010-59572688
Email
ningzi.li@inno-chem.com.cn
Country
China
ProdList
6139
Advantage
55
9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
22519
Advantage
55
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-400-6206333 18521732826
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
25014
Advantage
65
The future of Shanghai Industrial Co., Ltd.
Tel
021-61552785
Fax
021-55660885
Email
sales@shshiji.com
Country
China
ProdList
9552
Advantage
55
Cantotech Chemicals, Ltd.
Tel
86-0755-86635001
Fax
86-0755-22642228
Email
cantotech@126.com
Country
China
ProdList
4576
Advantage
55
Shanghai Yolne Chemical Co., Ltd.
Tel
021-62960152
Fax
021-52212593
Email
934678158@qq.com
Country
China
ProdList
9906
Advantage
55
Chengdu AstaTech Trading Co., Ltd./AstaTech (Chengdu) Pharma. Co., Ltd.
Tel
+86-28-85122536 85324413
Fax
+86-28-85326443
Email
market@astatech.cn
Country
China
ProdList
8033
Advantage
55
Quzhou Juhua Friendship Co., Ltd
Tel
0570-3066667
Fax
0570-3063388
Country
China
ProdList
3933
Advantage
58
Huainan Kedi Chemical Factory
Tel
0554-2106669
Fax
0554-2666215
Email
sales1@kedichem.com
Country
China
ProdList
4928
Advantage
55
Chemwill Asia Co.,Ltd.
Tel
86-21-51086038
Fax
86-21-51861608
Country
China
ProdList
2931
Advantage
58
Shanghai Worldyang Chemical Co.,Ltd.
Tel
021-021-56795766
Fax
+86-21-56795266
Email
sales@worldyachem.com
Country
China
ProdList
9352
Advantage
58
Chengdu HuaXia Chemical Reagent Co. Ltd
Tel
400-1166-196 13458535857
Fax
QQ：800101999
Email
cdhxsj@163.com
Country
China
ProdList
13359
Advantage
58
Wuxi Zhongkun Biochemical Technology Co., Ltd.
Tel
0510-85629785 18013409632
Fax
051085625359
Email
sales@reading-chemicals.com
Country
China
ProdList
15185
Advantage
58
Shanghai Macklin Biochemical Co.,Ltd.
Tel
15221275939 15221275939
Fax
021-50706099
Email
shenlinxing@macklin.cn
Country
China
ProdList
15885
Advantage
55
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51471
Advantage
80
Giant chemicals
Tel
028-85434334 18108076537
Fax
QQ：245797092
Email
market@gianthx.com
Country
China
ProdList
4512
Advantage
56
Chengdu Research Accelerators Technology Co., Ltd.
Tel
028-64353063
Fax
028-64353063 QQ:784253935
Email
reacchemical@163.com
Country
China
ProdList
5259
Advantage
58
Chengdu RunZeBenTu Chemical Co., Ltd
Tel
028-88469284 18000562381
Email
rzbtsj@163.com
Country
China
ProdList
9958
Advantage
56
AOKBIO Inc.
Tel
021-68712331 3286104197
Fax
021 68712331
Country
China
ProdList
323
Advantage
55
ShangHai Siyan Biological Technology Co., Ltd.
Tel
021-50908862，442785678，326799392 18721037013
Fax
021-50908862
Email
siyansales@126.com
Country
China
ProdList
9638
Advantage
58
Shanghai Xilong Biochemical Technology Co., Ltd.
Tel
021-52907766-8042
Fax
021-52906523
Country
China
ProdList
9947
Advantage
58
Shandong Xiya Chemical Co., Ltd.
Tel
4009903999 13395398332
Fax
0539-6365991
Email
sales@xiyashiji.com
Country
China
ProdList
20810
Advantage
60
Chengdu Dianchun Technology Co., Ltd
Tel
400-1166-196 18502815961
Fax
QQ：800101999
Email
cdhxsj@163.com
Country
China
ProdList
14623
Advantage
60
Grader reagent
Tel
18221735425
Email
sales@xinpingchem.com
Country
China
ProdList
9951
Advantage
58
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131980
Advantage
58
Shenzhen Sendi Biological Technology Co., Ltd.
Tel
18124570582 TEL：0755-23574479 2355327139
Fax
0755-23229476 QQ: 2355327139
Email
siliao02@yccreate.com
Country
China
ProdList
6120
Advantage
58
Guangzhou Kafen Biotech Co.,Ltd
Tel
18029243487 2355327168
Fax
020-31121510
Email
gy@yccreate.com
Country
China
ProdList
4753
Advantage
55
Chengdu Synguider Technology Co., Ltd.
Tel
400-086-3412 028-85062459
Fax
028-85062459
Email
synguider@163.com
Country
China
ProdList
3300
Advantage
55
Taian Jiaye Biotechnology Co.Ltd
Tel
13127280945
Email
285424065@qq.com
Country
China
ProdList
9980
Advantage
55
Shanghai Orgchem Co.,Ltd.
Tel
+86-21-5877 1921
Fax
+86-21-5877 1925
Email
info@chemofchina.com
Country
China
ProdList
9661
Advantage
55
More
Less

View Lastest Price from 2-Methoxy-4-nitroaniline manufacturers

Hebei Guanlang Biotechnology Co., Ltd.
Product
2-Methoxy-4-nitroaniline 97-52-9
Price
US $10.00/PCS
Min. Order
1KG
Purity
99%
Supply Ability
100 mt
Release date
2021-05-12
Hebei Mojin Biotechnology Co., Ltd
Product
2-Methoxy-4-nitroaniline 97-52-9
Price
US $100.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
5000KG
Release date
2023-08-25
Taizhou Suze Chemical Materials Co.,Ltd.
Product
2-Methoxy-4-nitroaniline 97-52-9
Price
US $0.00/kg
Min. Order
1kg
Purity
97.7%
Supply Ability
24 tons
Release date
2022-11-21

97-52-9, 2-Methoxy-4-nitroanilineRelated Search:

2-Methyl-4-methoxybenzenamine o-Anisidine 2-Methyl-4-nitroaniline p-Anisidine 3-Amino-4-methoxybenzanilide 4-Methyl-2-nitroaniline 2-Methoxyethanol 4-(Trifluoromethoxy)aniline N-Methyl-4-nitroaniline 4-(2,5-Diethoxy-4-nitrophenyl)morpholine NITROGEN DIOXIDE 4-Chloro-2-nitroaniline 4-METHOXY-2-NITROANILINE,2-nitro-p-anisidine 4-methoxy-2-nitroaniline anisidine 2-METHOXY-5-NITROANILINE,2-AMINO-4-NITROANISOLE(2-METHOXY-5-NITROANILINE),2-Methoxy-5-nitroaniline, 98+% 4-Nitroaniline 2-Nitroaniline 3-Nitroaniline

  • redbasecibav
  • redbaseirgav
  • METHOXY-4-NITROANILINE
  • Brilliant Red Developing Base 4B
  • 4-NITRO-ORTHO-ANISIDINE
  • -Amino-5-nitrophenyl methyl ether
  • RED B ASE
  • RED B BASE
  • RED R BASE
  • 4-Nitro-o-anisidine (NH2=1)
  • Benzenamine, 2-methoxy-4-nitro-
  • 4-NITRO-2-ANISIDINE ( 2-METHOXY-4-NITRO ANILINE )
  • 5-NITRO-2-AMINOANISOLE
  • 5-NITRO-2-ANISIDINE
  • 4-NITRO-O-ANISIDINE
  • 4-NITRO-2-METHOXYANILINE
  • 1-AMINO-2-METHOXY-4-NITROBENZENE
  • 2-Amino-5-nitroanis01
  • 2-AMINO-5-NITROANISOLE
  • 2-METHOXY-4-NITROANILINE
  • 2-methoxy-4-nitro-benzenamin
  • 2-Methoxy-4-nitrobenzenamine
  • 2-methoxy-4-nitro-Benzenamine
  • Amarthol fast red b base
  • amartholfastredbbase
  • naphthanilredbbase
  • Naphthoelan red B base
  • naphthoelanredbbase
  • Naphtoelan red b base
  • Nuclear fast red B salt
  • o-Anisidine, 4-nitro-
  • p-Nitro-o-anisidine
  • Pnoa
  • Red base ciba v
  • Red base irga v
  • Red base nb
  • RedbaseB
  • 3-Nitro-6-aminoanisole
  • 4-Amino-3-methoxynitrobenzene
  • 4-Nitro-6-methoxyaniline
  • 4-nitro-o-anisidin
  • redbasenb
  • Sanyo fast red b base
  • sanyofastredbbase
  • Shinnippon fast red b base
  • shinnipponfastredbbase
  • Showa fast red b base
  • showafastredbbase
  • Symulon red b base
  • symulonredbbase
  • 2-Methoxy-4-nitroani
  • 2-Methoxy-4-nitroaniline, 99% 100GR
  • 2-Methoxy-4-nitroaniline (Fast Red B)
  • illiant Red Developing Base 4B
  • diabaseredb
  • Diazo fast red b
  • diazofastredb
  • Fast red 5na base