ACETYLSALICYLSALICYLIC ACID
- Product Name
- ACETYLSALICYLSALICYLIC ACID
- CAS No.
- 530-75-6
- Chemical Name
- ACETYLSALICYLSALICYLIC ACID
- Synonyms
- 2-(Ace;Acesalum;DIPLOSALSALATE;Diplosalacetat;Diplosal Acetate;Aspirin IMpurity D;Aspirin Impurity 4;Aspirin EP IMpurity D;Carbasalate EP Impurity B;ACETYLSALISYLIC ACID IMP D
- CBNumber
- CB7385272
- Molecular Formula
- C16H12O6
- Formula Weight
- 300.26
- MOL File
- 530-75-6.mol
ACETYLSALICYLSALICYLIC ACID Property
- Melting point:
- 153-160 °C
- Boiling point:
- 361.5°C (rough estimate)
- Density
- 1.346
- refractive index
- 1.4600 (estimate)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Chloroform (Sparingly), DMSO (Sparingly), Methanol (Slightly)
- pka
- 2.94±0.36(Predicted)
- form
- Solid
- color
- White to Off-White
- Water Solubility
- 20mg/L(21 ºC)
- InChI
- InChI=1S/C16H12O6/c1-10(17)21-14-9-5-3-7-12(14)16(20)22-13-8-4-2-6-11(13)15(18)19/h2-9H,1H3,(H,18,19)
- InChIKey
- DDSFKIFGAPZBSR-UHFFFAOYSA-N
- SMILES
- C(OC1=CC=CC=C1C(O)=O)(=O)C1=CC=CC=C1OC(C)=O
- EPA Substance Registry System
- 2-Carboxyphenyl 2-(acetyloxy)benzoate (530-75-6)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- Y0001161
- Product name
- Carbasalate impurity B
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- 5 mg
- Price
- $118
- Updated
- 2025/07/31
- Product number
- PHR1940
- Product name
- Carbasalate impurity B
- Packaging
- 50mg
- Price
- $734
- Updated
- 2025/07/31
- Product number
- Y0001161
- Product name
- Carbasalate impurity B
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- y0001161
- Price
- $150
- Updated
- 2024/03/01
- Product number
- A187788
- Product name
- AcetylsalicylsalicylicAcid
- Packaging
- 100mg
- Price
- $135
- Updated
- 2021/12/16
- Product number
- Z4833
- Product name
- 2-((2-Acetoxybenzoyl)oxy)benzoicacid
- Packaging
- 1g
- Price
- $230
- Updated
- 2021/12/16
ACETYLSALICYLSALICYLIC ACID Chemical Properties,Usage,Production
Chemical Properties
white to almost white fine crystalline powder
Uses
Antiinflammatory;Cyclooxygenase inhibitor
Uses
analgesic, antipyretic
Uses
Acetylsalicylic Acid Impurity C
Definition
ChEBI: 2-[(2-acetyloxyphenyl)-oxomethoxy]benzoic acid is a carbonyl compound.
Synthesis
552-94-3
108-24-7
530-75-6
To a solution of 2-((2-hydroxybenzoyl)oxy)benzoic acid (5.0 g, 19.37 mmol) in ethanoic anhydride (15.0 mL, 147.0 mmol) was added 3 drops of concentrated hydrochloric acid. The reaction mixture was stirred at room temperature for 16-20 hours. After completion of the reaction, the mixture was diluted with ice-cold water (50 mL) and the precipitated solid was collected by filtration. The solid was washed sequentially with water (2 x 10 mL) and hexane (20 mL) and dried to give 2-((2-acetoxybenzoyl)oxy)benzoic acid (5.5 g) as a white solid. Thin layer chromatography (TLC) Rf value was 0.3 (unfolding agent: 50% ethyl acetate/hexane).
Purification Methods
Crystallise the analgesic from dilute AcOH or EtOH (m 161-162o), MeOH (m 165-168o), and *C6H6/EtOH (m 163-165o). Its solubilities in boiling Et2O, *C6H6 and EtOH are 1.4%, 2.2% and 33%, respectively. [Baker et al. J Chem Soc 201 1951, Garrett et al. J Am Pharm Soc 48 684 1959, Beilstein 10 I 41, 10 II 54, 10 IV 165.]
References
[1] Chemical and Pharmaceutical Bulletin, 1985, vol. 33, # 5, p. 2158 - 2161
[2] Patent: US2014/357680, 2014, A1. Location in patent: Paragraph 0135-0136
[3] Patent: WO2014/195961, 2014, A1. Location in patent: Paragraph 00125; 00126
ACETYLSALICYLSALICYLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from ACETYLSALICYLSALICYLIC ACID manufacturers
- Product
- ACETYLSALICYLSALICYLIC ACID 530-75-6
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- JD 609
- Release date
- 2019-09-01