Octyl gallate
Description References- Product Name
- Octyl gallate
- CAS No.
- 1034-01-1
- Chemical Name
- Octyl gallate
- Synonyms
- Progallin O;OCTYL GALLATE;N-OCTYL GALLATE;Stabilizer GA-8;OCTYLGALLATE(RG);Gallic acid octyl;n-OctylGallate>Octyl gallate CRS;n-Octyl gallate, 98+%;GALLIC ACID OCTYL ESTER
- CBNumber
- CB8704027
- Molecular Formula
- C15H22O5
- Formula Weight
- 282.33
- MOL File
- 1034-01-1.mol
Octyl gallate Property
- Melting point:
- 101-104 °C(lit.)
- Boiling point:
- 262.5°C (estimate)
- Density
- 1.0984 (rough estimate)
- refractive index
- 1.6200 (estimate)
- storage temp.
- Store below +30°C.
- solubility
- soluble2.5%, clear, colorless (AcOH (MEOH))
- form
- Solid
- pka
- 7.94±0.25(Predicted)
- color
- White to Off-White
- Water Solubility
- 20mg/L(29.99 ºC)
- BRN
- 2132305
- InChI
- InChI=1S/C15H22O5/c1-2-3-4-5-6-7-8-20-15(19)11-9-12(16)14(18)13(17)10-11/h9-10,16-18H,2-8H2,1H3
- InChIKey
- NRPKURNSADTHLJ-UHFFFAOYSA-N
- SMILES
- C(OCCCCCCCC)(=O)C1=CC(O)=C(O)C(O)=C1
- LogP
- 3.660
- CAS DataBase Reference
- 1034-01-1(CAS DataBase Reference)
- EPA Substance Registry System
- Benzoic acid, 3,4,5-trihydroxy-, octyl ester (1034-01-1)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H317May cause an allergic skin reaction
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
N-Bromosuccinimide Price
- Product number
- Y0000368
- Product name
- Octyl gallate
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- 30 mg
- Price
- $153
- Updated
- 2025/07/31
- Product number
- 48700
- Product name
- Octyl gallate
- Purity
- antioxidant, ≥99.0% (HPLC)
- Packaging
- 50g
- Price
- $141
- Updated
- 2025/07/31
- Product number
- PHR3511
- Product name
- Octyl Gallate
- Purity
- certified reference material, pharmaceutical secondary standard
- Packaging
- 500MG
- Price
- $247.95
- Updated
- 2025/07/31
- Product number
- 48700
- Product name
- Octyl gallate
- Purity
- antioxidant, ≥99.0% (HPLC)
- Packaging
- 250g
- Price
- $624
- Updated
- 2025/07/31
- Product number
- 06717
- Product name
- Octyl gallate
- Purity
- analytical standard
- Packaging
- 500mg
- Price
- $102
- Updated
- 2022/05/15
Octyl gallate Chemical Properties,Usage,Production
Description
Octyl gallate is the ester formed by 1-octanol and gallic acid. It can be used as an antioxidant and preservative to be supplemented to the food. It has been demonstrated to be an effective fungicide being capable of inhibiting the growth of S. cerevisiae and Z. bailii as it can inhibit the fluidity of the cell membrane through acting as a nonionic surface-active agent. It is also capable of killing both DNA and RNA viruses with a relatively moderate cytotoxicity. For example, it has the potential to treat influenza. Octyl gallate also has certain bactericidal activity, being capable of treating the infections associated with enterococci.
References
[1]Ken-Ichi, Fujita, and K. Isao. "Antifungal activity of octyl gallate. " International Journal of Food Microbiology 79.3(2002):1
[2]Gutiérrez-Fernández, J, et al. "Antimicrobial activity of binary combinations of natural and synthetic phenolic antioxidants against Enterococcus faecalis. " Journal of Dairy Science 96.8(2013):4912-20.93.
[3] Yamasaki, H, et al. "Antiviral effect of octyl gallate against influenza and other RNA viruses. " International Journal of Molecular Medicine 19.4(2007): 685-688.
Description
During the 1940s, propyl gallate and several other alkyl gallates were allowed for use in foods in a number of countries. Since gallic acid contains three phenolic hydroxyl groups, it is a rather potent antioxidant; however, the propyl ester has a significant degree of water solubility. As a consequence, propyl gallate tends to partition into any water phase which may be present and to complex with iron salts to give bluish black colors. Also, its relatively poor resistance to heat degradation makes it ineffective for baking and frying applications. The higher alkyl gallates (butyl and octyl) are more fat soluble.
Chemical Properties
White powder
Uses
Used in treatment of alcohol dependence.
Uses
Octyl gallate is an antioxidant that is used as a preservation agent in a wide variety of foods, oils, and cosmetics.
Uses
Octyl gallate is an antioxidant for use in cosmetic and pharmaceutical products and in food products, such as margarine and peanut butter.
Definition
ChEBI: A gallate ester obtained by condensation of the carboxy group of gallic acid with the hydroxy group of octanol.
General Description
Octyl gallate is an ester of gallic acid which is generally used as an antioxidant in food and pharmaceutical industries. It can act against the oxidative damage caused by reactive oxygen species (ROS) in the form of hydroxyl radicals or hydrogen peroxides, and reactive sulfur species (RSS)
Contact allergens
Octyl gallate, a gallate ester (E 311), is an antioxidant added to food and cosmetics to prevent oxidation of unsaturated fatty acids. Cases were sparsely reported in food industry or from lipsticks. Patch tests are frequently irritant.
Safety Profile
A poison by intraperitoneal route. Moderately toxic by ingestion. When heated to decomposition it emits acrid smoke and irritating fumes.
Synthesis
111-87-5
149-91-7
1034-01-1
Gallic acid (0.3 mmol, 50 mg), octanol (0.9 mmol) and concentrated sulfuric acid (0.07 mL) were added to the microwave reaction flask. After sealing the reaction bottle, it was placed in a microwave reactor and the reaction was radiated at 100 °C for 50 min. After completion of the reaction, it was cooled to room temperature and the volatile components of the reaction mixture were evaporated to dryness. The residue was dissolved with ethyl acetate (30 mL) and washed sequentially with saturated sodium bicarbonate solution (3 x 20 mL) and sodium chloride solution (1 x 20 mL). The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The resulting crude product was purified by column chromatography with the eluent being a solvent mixture of hexane/ethyl acetate in the ratio of 3:7, v/v/v/v. The melting point and spectral data of the target compound octyl gallate were in agreement with those reported in literature [25d]. The isolated yield of octyl gallate was 70% under the present experimental conditions.
References
[1] European Journal of Medicinal Chemistry, 2015, vol. 92, p. 656 - 671
[2] Journal of Agricultural and Food Chemistry, 2002, vol. 50, # 14, p. 3992 - 3998
[3] Journal of Agricultural and Food Chemistry, 2002, vol. 50, # 23, p. 6692 - 6696
[4] Journal of Agricultural and Food Chemistry, 2000, vol. 48, # 4, p. 1393 - 1399
[5] Arzneimittel-Forschung/Drug Research, 2005, vol. 55, # 1, p. 66 - 75
Octyl gallate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Octyl gallate manufacturers
- Product
- Octyl gallate 1034-01-1
- Price
- US $6.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 2000KG/Month
- Release date
- 2024-08-08
- Product
- Octyl Gallate 1034-01-1
- Price
- US $65.00-20.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20ton
- Release date
- 2024-05-31
- Product
- Octyl gallate 1034-01-1
- Price
- US $6.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20TONS
- Release date
- 2024-05-10