Ethyl gallate
- Product Name
- Ethyl gallate
- CAS No.
- 831-61-8
- Chemical Name
- Ethyl gallate
- Synonyms
- Progallin A;progallina;ETHYL 3,4,5-TRIHYDROXYBENZOATE;nipa48;Nipa No. 48;Phyllemblin;nipagallina;Nipagallin A;Ethyl gallat;ETHYL GALLATE
- CBNumber
- CB3453922
- Molecular Formula
- C9H10O5
- Formula Weight
- 198.17
- MOL File
- 831-61-8.mol
Ethyl gallate Property
- Melting point:
- 149-153 °C
- Boiling point:
- 255.48°C (rough estimate)
- Density
- 1.2539 (rough estimate)
- refractive index
- 1.4570 (estimate)
- storage temp.
- Store below +30°C.
- solubility
- DMSO (Slightly), Methanol (Very Slightly)
- pka
- 8.04±0.23(Predicted)
- form
- Fine Powder
- color
- White to slightly beige
- Water Solubility
- soluble
- BRN
- 2116014
- InChIKey
- VFPFQHQNJCMNBZ-UHFFFAOYSA-N
- LogP
- 1.300
- CAS DataBase Reference
- 831-61-8(CAS DataBase Reference)
- NIST Chemistry Reference
- Gallic acid, ethyl ester(831-61-8)
- EPA Substance Registry System
- Benzoic acid, 3,4,5-trihydroxy-, ethyl ester (831-61-8)
Safety
- Safety Statements
- 24/25
- WGK Germany
- 2
- RTECS
- LW7700000
- TSCA
- Yes
- HS Code
- 29182900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H317May cause an allergic skin reaction
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- PHL83080
- Product name
- Ethyl gallate
- Purity
- phyproof<SUP>®</SUP> Reference Substance
- Packaging
- 100 mg
- Price
- $281
- Updated
- 2025/07/31
- Product number
- 8.20597
- Product name
- Ethyl 3,4,5-trihydroxybenzoate
- Purity
- for synthesis
- Packaging
- 100g
- Price
- $136
- Updated
- 2025/07/31
- Product number
- 48640
- Product name
- Ethyl gallate
- Purity
- antioxidant, ≥96.0% (HPLC)
- Packaging
- 100g
- Price
- $157
- Updated
- 2025/07/31
- Product number
- 48640
- Product name
- Ethyl gallate
- Purity
- antioxidant, ≥96.0% (HPLC)
- Packaging
- 500g
- Price
- $313
- Updated
- 2023/06/20
- Product number
- E0854
- Product name
- Ethyl Gallate [for Determination of Total Polyphenol Content]
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $55
- Updated
- 2025/07/31
Ethyl gallate Chemical Properties,Usage,Production
Description
Ethyl gallate is a food additive with E number E313. It is the ethyl ester of gallic acid. Ethyl gallate is added to food as an antioxidant.
Though found naturally in a variety of plant sources including walnuts
Terminalia myriocarpa or chebulic myrobolan (Terminalia chebula).
Ethyl gallate is produced from gallic acid and ethanol. It can be found in wine.
Chemical Properties
white to slightly beige fine powder
Uses
Antioxidant.
Uses
Ethyl Gallate is an apoptotic agent as a polyphenol compound. Antiproliferative.
Definition
ChEBI: A gallate ester obtained by the formal condensation of gallic acid with ethanol.
General Description
This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG
Synthesis
64-17-5
149-91-7
831-61-8
1. 100 g of gallic acid and 150 g of ethanol were added to the reactor. 2. 35 g of bromine-modified sulfonic acid resin (prepared as in Example 2) was added. 3. The reaction mixture was heated to 80°C for 5 hours. 4. After completion of the reaction, the filtrate and the bromine-modified sulfonic acid resin were separated by filtration. 5. The filtrate was distilled to remove excess ethanol to obtain the crude product. 6. The crude product was recrystallized using deionized water. 7. The recrystallized product was dehydrated and dried. 8. Ethyl gallate was obtained in 98% yield and 99% purity. 9. The crude product was recrystallized using deionized water. 7. The recrystallized product was dehydrated and dried. 8. Ethyl gallate was obtained with a yield of 98% and a purity of 99.9%. 9.
Purification Methods
Recrystallise the gallate from 1,2-dichloroethane, UV: max (neutral species) 275nm ( 10 000), (anion) 235nm ( 10 300), 279nm ( 11 400) and 324nm ( 8 500) [Campbell & Coppinger J Am Chem Soc 73 2708 1951]. [Beilstein 10 IV 2002.]
References
[1] Patent: CN105294433, 2016, A. Location in patent: Paragraph 0026
[2] Asian Journal of Chemistry, 2015, vol. 27, # 4, p. 1351 - 1354
[3] New Journal of Chemistry, 2018, vol. 42, # 20, p. 16999 - 17008
[4] ChemPhysChem, 2016, p. 2225 - 2237
[5] Tetrahedron, 2009, vol. 65, # 40, p. 8354 - 8361
Ethyl gallate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Ethyl gallate manufacturers
- Product
- Ethyl gallate 831-61-8
- Price
- US $0.00/g
- Min. Order
- 100g
- Purity
- ≥98%
- Supply Ability
- 10kg/month
- Release date
- 2021-09-29
- Product
- Ethyl gallate 831-61-8
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-10-29
- Product
- Ethyl gallate 831-61-8
- Price
- US $224.00/Kg/Drum
- Min. Order
- 1KG
- Purity
- 99.9%;
- Supply Ability
- 2000tons/month
- Release date
- 2020-07-08