Methyl gallate

Product Name: Methyl gallate
CAS No.: 99-24-1
Chemical Name: Methyl gallate
Synonyms: METHYL 3,4,5-TRIHYDROXYBENZOATE;GALLIC ACID METHYL ESTER;GALLICIN;Gallincin;methyl galloate;NSC 363001;AKOS 217-13;METHYGALLATE;METHYL GALLATE;MethylGallate>
CBNumber: CB0265566
Molecular Formula: C8H8O5
Formula Weight: 184.15
MOL File: 99-24-1.mol

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Methyl gallate Property

Melting point:: 201-204 °C
Boiling point:: 278.08°C (rough estimate)
Density: 1.3840 (rough estimate)
refractive index: 1.5690 (estimate)
storage temp.: Inert atmosphere,Room Temperature
solubility: ethanol: 50 mg/mL, clear
form: Crystalline Powder
pka: 8.04±0.23(Predicted)
color: White to slightly beige
Water Solubility: SOLUBLE IN HOT WATER
Merck: 14,4345
BRN: 2113180
InChI: 1S/C8H8O5/c1-13-8(12)4-2-5(9)7(11)6(10)3-4/h2-3,9-11H,1H3
InChIKey: FBSFWRHWHYMIOG-UHFFFAOYSA-N
SMILES: COC(=O)c1cc(O)c(O)c(O)c1
LogP: 0.860
CAS DataBase Reference: 99-24-1(CAS DataBase Reference)
EPA Substance Registry System: Benzoic acid, 3,4,5-trihydroxy-, methyl ester (99-24-1)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 22-36/37/38-43
Safety Statements: 26-36/37-24/25
WGK Germany: 3
RTECS: LW8000000
TSCA: TSCA listed
HS Code: 29182900
Storage Class: 11 - Combustible Solids
Hazard Classifications: Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 274194
Product name: Methyl 3,4,5-trihydroxybenzoate
Purity: 98%
Packaging: 5g
Price: $42.27
Updated: 2025/07/31

Sigma-Aldrich

Product number: PHL82592
Product name: Methyl gallate
Purity: phyproof<SUP>®</SUP> Reference Substance
Packaging: 100 mg
Price: $281
Updated: 2025/07/31

Sigma-Aldrich

Product number: 274194
Product name: Methyl 3,4,5-trihydroxybenzoate
Purity: 98%
Packaging: 100g
Price: $102.6
Updated: 2025/07/31

TCI Chemical

Product number: G0017
Product name: Methyl Gallate
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $24
Updated: 2025/07/31

TCI Chemical

Product number: G0017
Product name: Methyl Gallate
Purity: >98.0%(GC)(T)
Packaging: 100g
Price: $73
Updated: 2025/07/31

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Methyl gallate Chemical Properties,Usage,Production

Description

Methyl gallate is a phenolic compound found in Terminalia myriocarpa and Geranium niveum. It is also found in wine.
It is the methyl ester of gallic acid.

Description

Methyl gallate is a phenol that has been found in Meliaceae and has diverse biological activities. It reduces adipogenic hormonal stimulation-induced lipid accumulation in 3T3-L1 cells when used at a concentration of 50 μM. Methyl gallate is active against V. cholerae in vitro (MIC = 32 μg/ml) and reduces V. cholerae-induced intestinal fluid accumulation in suckling mice when administered at doses of 50, 100, and 200 mg/kg. It reduces tumor growth and decreases the number of intratumor CD25⁺Foxp3^high regulatory T cells (Tregs) in an EL-4 model of murine lymphoma. Methyl gallate (0.7, 7, and 70 mg/kg) reduces knee joint edema and leukocyte, neutrophil, and mononuclear cell infiltration in a mouse model of zymosan-induced arthritis.

Chemical Properties

white to slightly beige crystalline powder

Uses

Methyl gallate exhibits potent antitumor activities by inhibiting tumor infiltration of CD4+CD25+ regulatory T cells.

Uses

Methyl 3,4,5-trihydroxybenzoate exhibits potent antitumor activities by inhibiting tumor infiltration of CD4+CD25+ regulatory T cells.

Uses

The gallate ester methyl gallate is used as an antioxidant. A ease was reported using a reprography paper.

Definition

ChEBI: Methyl 3,4,5-trihydroxybenzoate is a gallate ester obtained by the formal condensation of gallic acid with methanol. It exhibits anti-oxidant, anti-tumor, anti-microbial and anti-inflammatory properties. It has a role as a plant metabolite, an anti-inflammatory agent and an antioxidant.

Contact allergens

This ester of gallic acid is used as an antioxidant agent. A case was reported by using a reprography paper.

Purification Methods

Methyl gallate [99-24-1] M 184.2, m 202o. Crystallise the gallate ester from MeOH. [Beilstein 10 IV 1998.]

References

[1] MISO JEON Yong S K Naimur Rahman. Wnt/β-catenin signaling plays a distinct role in methyl gallate–mediated inhibition of adipogenesis[J]. Biochemical and biophysical research communications, 2016, 479 1: Pages 22-27. DOI: 10.1016/j.bbrc.2016.08.178
[2] PRASANTA K. BAG . In vivo fluid accumulation-inhibitory, anticolonization and anti-inflammatory and in vitro biofilm-inhibitory activities of methyl gallate isolated from Terminalia chebula against fluoroquinolones resistant Vibrio cholerae[J]. Microbial pathogenesis, 2019, 128: Pages 41-46. DOI: 10.1016/j.micpath.2018.12.037
[3] HEEKYUNG LEE. Methyl gallate exhibits potent antitumor activities by inhibiting tumor infiltration of CD4+CD25+ regulatory T cells.[J]. Journal of immunology, 2010: 6698-6705. DOI: 10.4049/jimmunol.1001373
[4] LUANA BARBOSA CORREA. Anti-inflammatory Effect of Methyl Gallate on Experimental Arthritis: Inhibition of Neutrophil Recruitment, Production of Inflammatory Mediators, and Activation of Macrophages[J]. Journal of Natural Products , 2016, 79 6: 1554-1566. DOI: 10.1021/acs.jnatprod.5b01115

Methyl gallate Preparation Products And Raw materials

Raw materials

Gallic acid

Preparation Products

3,4-DIHYDROXY-5-METHOXYBENZOIC ACID METHYL ESTER 4-BROMO-7-METHOXY-BENZO[1,3]DIOXOLE-5-CARBOXYLIC ACID METHYL ESTER

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Methyl gallate Suppliers

Americas 1 Belgium 1 Canada 2 CHINA 430 Europe 1 France 1 Germany 6 India 28 Japan 3 Poland 1 Slovakia 1 South Korea 1 Switzerland 2 Ukraine 1 United Kingdom 11 United States 49 USA 1 Global 540

WUFENG CHICHENG BIOTECH CO LTD

Tel: 0717-5757168 13997700995
Email: wfcchem@126.com
Country: China
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Hubei Hongfuda Biotechnology Co., Ltd.

Tel: 180-86404407 17340521416
Email: 1757224788@qq.com
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Nantong Fotunte Chemical Special Biotechnology Co., Ltd

Tel: 0513-86920019 13382489788
Email: 2084708089@qq.com
Country: China
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J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
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Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
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3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
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Email: 3bsc@sina.com
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future industrial shanghai co., ltd

Tel: 400-0066400 13621662912
Fax: 021-55660885
Email: sales@jonln.com
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Chembest Research Laboratories Limited

Tel: +86-21-20908456
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Email: sales@BioChemBest.com
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Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
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TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

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View Lastest Price from Methyl gallate manufacturers

Hebei Fengjia New Material Co., Ltd

Product: Methyl gallate 99-24-1
Price: US $6.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 10000
Release date: 2024-09-05

Hebei Chuanghai Biotechnology Co., Ltd

Product: Methyl gallate 99-24-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-21

Hebei Yanxi Chemical Co., Ltd.

Product: Methyl Gallate 99-24-1
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100tons
Release date: 2024-06-19

99-24-1, Methyl gallateRelated Search:

2,3,4-Trihydroxybenzoic acid Paraquat dichloride Propyl gallate Methylparaben Methyl 3,4-dihydroxybenzoate Methyl acetate Methyl acrylate Basic Violet 1 Ethyl gallate Methyl 3-hydroxybenzoate Salicylic acid Methanol Kresoxim-methyl Pyrogallol Gallic acid monohydrate 2'-Hydroxy-3-phenylpropiophenone 3-Hydroxybenzoic acid Acetonitrile

3,4,5-trihydroxybenzoic acid methyl ester (intermediate of bifendate)

METHYL GALLATE(METHYL 3,4,5-TRIHYDROXYBENZOATE )

METHYLGALLATE(RG)

2-diazo-1-naphthol-5-sulfonic acid, ester with novolac

METHYGALLATE

3,4,5-trihydroxy-benzoic acidd methyl ester

METHYL 3,4,5-TRIHYDROXYBENZOATE / METHYL GALLATE

Gallic acid methyl ester, Methyl 3,4,5-trihydroxybenzoate

Benzoic acid, 3,4,5-trihydroxy, methyl ester

Methyl 3,4,5-trihydroxybenzoate, 99 %

(3aS,10E)-3aβ,4,5,6,7,8,9,11aα-Octahydro-7α-hydroxy-6-methylene-3β,10-dimethylcyclodeca[b]furan-2(3H)-one

thyl 3,4,5-trihydroxybenzoate

METHYL GALLATE

METHYL 3,4,5-TRIHYDROXYBENZOATE

GALLIC ACID METHYL ESTER

GALLICIN

3,4,5-TRIHYDROXYBENZOIC ACID METHYL ESTER

AKOS 217-13

Methyl 3,4,5-trihydroxybenzoate, 99% 50GR

Methyl 3,4,5-trihydroxybenzoate, 99% 5GR

RARECHEM AL BF 0070

3,4,5-trihydroxy-benzoicacimethylester

Methyl 3,4,5-trihydroxybenzoate 98%

Methyl 3,4,5-trihydroxybenzoate, 98.0%(GC&T

Methyl Gallate≥98%

Methyle3, 4, 5-trihydroxybenzoate

methyl galloate

Methyl gallate 99-24-1 Methyl 3,4,5-trihydroxybenzoate

Methyl 3,4,5-trihydroxybenzoate 99-24-1 Methyl gallate

MethylGallate&gt

Gallincin

NSC 363001

Methyl Gallate ( Methyl 3,4,5-Trihydroxy Benzoate -98%)

Methyl gallate (Gallincin

Methyl gallate-RM

Methyl gallate, 10 mM in DMSO

99-24-1

99-54-1

HO3C6H2COOCH3

HO3C6H2CO2CH3

Alphabetic

Analytical Chromatography Product Catalog

Analytical Standards

META - METH

Food additive ,Antioxidant anticorrosive

(intermediate of bifendate)

Aromatic Esters

Organic acids

Photo Active Compounds