Methyl gallate
- Product Name
- Methyl gallate
- CAS No.
- 99-24-1
- Chemical Name
- Methyl gallate
- Synonyms
- METHYL 3,4,5-TRIHYDROXYBENZOATE;GALLIC ACID METHYL ESTER;GALLICIN;Gallincin;methyl galloate;NSC 363001;AKOS 217-13;METHYGALLATE;METHYL GALLATE;MethylGallate>
- CBNumber
- CB0265566
- Molecular Formula
- C8H8O5
- Formula Weight
- 184.15
- MOL File
- 99-24-1.mol
Methyl gallate Property
- Melting point:
- 201-204 °C
- Boiling point:
- 278.08°C (rough estimate)
- Density
- 1.3840 (rough estimate)
- refractive index
- 1.5690 (estimate)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- ethanol: 50 mg/mL, clear
- form
- Crystalline Powder
- pka
- 8.04±0.23(Predicted)
- color
- White to slightly beige
- Water Solubility
- SOLUBLE IN HOT WATER
- Merck
- 14,4345
- BRN
- 2113180
- InChIKey
- FBSFWRHWHYMIOG-UHFFFAOYSA-N
- LogP
- 0.860
- CAS DataBase Reference
- 99-24-1(CAS DataBase Reference)
- EPA Substance Registry System
- Benzoic acid, 3,4,5-trihydroxy-, methyl ester (99-24-1)
Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 22-36/37/38-43
- Safety Statements
- 26-36/37-24/25
- WGK Germany
- 3
- RTECS
- LW8000000
- TSCA
- Yes
- HS Code
- 29182900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 274194
- Product name
- Methyl 3,4,5-trihydroxybenzoate
- Purity
- 98%
- Packaging
- 5g
- Price
- $42.27
- Updated
- 2025/07/31
- Product number
- PHL82592
- Product name
- Methyl gallate
- Purity
- phyproof<SUP>®</SUP> Reference Substance
- Packaging
- 100 mg
- Price
- $281
- Updated
- 2025/07/31
- Product number
- 274194
- Product name
- Methyl 3,4,5-trihydroxybenzoate
- Purity
- 98%
- Packaging
- 100g
- Price
- $102.6
- Updated
- 2025/07/31
- Product number
- G0017
- Product name
- Methyl Gallate
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $24
- Updated
- 2025/07/31
- Product number
- G0017
- Product name
- Methyl Gallate
- Purity
- >98.0%(GC)(T)
- Packaging
- 100g
- Price
- $73
- Updated
- 2025/07/31
Methyl gallate Chemical Properties,Usage,Production
Description
Methyl gallate is a phenolic compound found in Terminalia myriocarpa and Geranium niveum. It is also found in wine.
It is the methyl ester of gallic acid.
Description
Methyl gallate is a phenol that has been found in Meliaceae and has diverse biological activities. It reduces adipogenic hormonal stimulation-induced lipid accumulation in 3T3-L1 cells when used at a concentration of 50 μM. Methyl gallate is active against V. cholerae in vitro (MIC = 32 μg/ml) and reduces V. cholerae-induced intestinal fluid accumulation in suckling mice when administered at doses of 50, 100, and 200 mg/kg. It reduces tumor growth and decreases the number of intratumor CD25+Foxp3high regulatory T cells (Tregs) in an EL-4 model of murine lymphoma. Methyl gallate (0.7, 7, and 70 mg/kg) reduces knee joint edema and leukocyte, neutrophil, and mononuclear cell infiltration in a mouse model of zymosan-induced arthritis.
Chemical Properties
white to slightly beige crystalline powder
Uses
Methyl gallate exhibits potent antitumor activities by inhibiting tumor infiltration of CD4+CD25+ regulatory T cells.
Uses
Methyl 3,4,5-trihydroxybenzoate exhibits potent antitumor activities by inhibiting tumor infiltration of CD4+CD25+ regulatory T cells.
Uses
The gallate ester methyl gallate is used as an antioxidant. A ease was reported using a reprography paper.
Definition
ChEBI: Methyl 3,4,5-trihydroxybenzoate is a gallate ester obtained by the formal condensation of gallic acid with methanol. It exhibits anti-oxidant, anti-tumor, anti-microbial and anti-inflammatory properties. It has a role as a plant metabolite, an anti-inflammatory agent and an antioxidant.
Contact allergens
This ester of gallic acid is used as an antioxidant agent. A case was reported by using a reprography paper.
Purification Methods
Methyl gallate [99-24-1] M 184.2, m 202o. Crystallise the gallate ester from MeOH. [Beilstein 10 IV 1998.]
References
[1] MISO JEON Yong S K Naimur Rahman. Wnt/β-catenin signaling plays a distinct role in methyl gallate–mediated inhibition of adipogenesis[J]. Biochemical and biophysical research communications, 2016, 479 1: Pages 22-27. DOI: 10.1016/j.bbrc.2016.08.178
[2] PRASANTA K. BAG . In vivo fluid accumulation-inhibitory, anticolonization and anti-inflammatory and in vitro biofilm-inhibitory activities of methyl gallate isolated from Terminalia chebula against fluoroquinolones resistant Vibrio cholerae[J]. Microbial pathogenesis, 2019, 128: Pages 41-46. DOI: 10.1016/j.micpath.2018.12.037
[3] HEEKYUNG LEE. Methyl gallate exhibits potent antitumor activities by inhibiting tumor infiltration of CD4+CD25+ regulatory T cells.[J]. Journal of immunology, 2010: 6698-6705. DOI: 10.4049/jimmunol.1001373
[4] LUANA BARBOSA CORREA. Anti-inflammatory Effect of Methyl Gallate on Experimental Arthritis: Inhibition of Neutrophil Recruitment, Production of Inflammatory Mediators, and Activation of Macrophages[J]. Journal of Natural Products , 2016, 79 6: 1554-1566. DOI: 10.1021/acs.jnatprod.5b01115
Methyl gallate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Methyl gallate manufacturers
- Product
- Methyl gallate 99-24-1
- Price
- US $6.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 10000
- Release date
- 2024-09-05
- Product
- Methyl gallate 99-24-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-21
- Product
- Methyl Gallate 99-24-1
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100tons
- Release date
- 2024-06-19