Methyl gallate
- Product Name
- Methyl gallate
- CAS No.
- 99-24-1
- Chemical Name
- Methyl gallate
- Synonyms
- METHYL 3,4,5-TRIHYDROXYBENZOATE;GALLICIN;GALLIC ACID METHYL ESTER;Gallincin;methyl galloate;NSC 363001;AKOS 217-13;METHYGALLATE;METHYL GALLATE;MethylGallate>
- CBNumber
- CB0265566
- Molecular Formula
- C8H8O5
- Formula Weight
- 184.15
- MOL File
- 99-24-1.mol
Methyl gallate Property
- Melting point:
- 201-204 °C
- Boiling point:
- 278.08°C (rough estimate)
- Density
- 1.3840 (rough estimate)
- refractive index
- 1.5690 (estimate)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- ethanol: 50 mg/mL, clear
- form
- Crystalline Powder
- pka
- 8.04±0.23(Predicted)
- color
- White to slightly beige
- Water Solubility
- SOLUBLE IN HOT WATER
- Merck
- 14,4345
- BRN
- 2113180
- InChI
- 1S/C8H8O5/c1-13-8(12)4-2-5(9)7(11)6(10)3-4/h2-3,9-11H,1H3
- InChIKey
- FBSFWRHWHYMIOG-UHFFFAOYSA-N
- SMILES
- COC(=O)c1cc(O)c(O)c(O)c1
- LogP
- 0.860
- CAS DataBase Reference
- 99-24-1(CAS DataBase Reference)
- EPA Substance Registry System
- Benzoic acid, 3,4,5-trihydroxy-, methyl ester (99-24-1)
Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 22-36/37/38-43
- Safety Statements
- 26-36/37-24/25
- WGK Germany
- 3
- RTECS
- LW8000000
- TSCA
- TSCA listed
- HS Code
- 29182900
- Storage Class
- 11 - Combustible Solids
- Hazard Classifications
- Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 274194
- Product name
- Methyl 3,4,5-trihydroxybenzoate
- Purity
- 98%
- Packaging
- 5g
- Price
- $47.4
- Updated
- 2026/04/30
- Product number
- PHL82592
- Product name
- Methyl gallate
- Purity
- phyproof<SUP>®</SUP> Reference Substance
- Packaging
- 100 mg
- Price
- $301
- Updated
- 2026/04/30
- Product number
- 274194
- Product name
- Methyl 3,4,5-trihydroxybenzoate
- Purity
- 98%
- Packaging
- 100g
- Price
- $115
- Updated
- 2026/04/30
- Product number
- G0017
- Product name
- Methyl Gallate
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $24
- Updated
- 2026/04/30
- Product number
- G0017
- Product name
- Methyl Gallate
- Purity
- >98.0%(GC)(T)
- Packaging
- 100g
- Price
- $73
- Updated
- 2026/04/30
Methyl gallate Chemical Properties,Usage,Production
Description
Methyl gallate is a phenolic compound found in Terminalia myriocarpa and Geranium niveum. It is also found in wine.
It is the methyl ester of gallic acid.
Description
Methyl gallate is a phenol that has been found in Meliaceae and has diverse biological activities. It reduces adipogenic hormonal stimulation-induced lipid accumulation in 3T3-L1 cells when used at a concentration of 50 μM. Methyl gallate is active against V. cholerae in vitro (MIC = 32 μg/ml) and reduces V. cholerae-induced intestinal fluid accumulation in suckling mice when administered at doses of 50, 100, and 200 mg/kg. It reduces tumor growth and decreases the number of intratumor CD25+Foxp3high regulatory T cells (Tregs) in an EL-4 model of murine lymphoma. Methyl gallate (0.7, 7, and 70 mg/kg) reduces knee joint edema and leukocyte, neutrophil, and mononuclear cell infiltration in a mouse model of zymosan-induced arthritis.
Chemical Properties
white to slightly beige crystalline powder
Uses
Methyl gallate exhibits potent antitumor activities by inhibiting tumor infiltration of CD4+CD25+ regulatory T cells.
Uses
Methyl 3,4,5-trihydroxybenzoate exhibits potent antitumor activities by inhibiting tumor infiltration of CD4+CD25+ regulatory T cells.
Uses
The gallate ester methyl gallate is used as an antioxidant. A ease was reported using a reprography paper.
Definition
ChEBI: Methyl 3,4,5-trihydroxybenzoate is a gallate ester obtained by the formal condensation of gallic acid with methanol. It exhibits anti-oxidant, anti-tumor, anti-microbial and anti-inflammatory properties. It has a role as a plant metabolite, an anti-inflammatory agent and an antioxidant.
Biological Activity
A large number of cell and animal experiments have shown that MG has good therapeutic effects, such as anti-tumor, anti-inflammatory, anti-oxidation, anti-microbial, anti-malarial and so on[5].
Contact allergens
This ester of gallic acid is used as an antioxidant agent. A case was reported by using a reprography paper.
Source
Methyl gallate is widely found in natural plants, such as Juglans mandshurica, Galla chinensis, Paeonia anomala, Phyllanthus emblica, Mangifera indica, Plicosepalus acacia, Carica papaya Linn, and Maple (Genus Acer)[5].
Purification Methods
Methyl gallate [99-24-1] M 184.2, m 202o. Crystallise the gallate ester from MeOH. [Beilstein 10 IV 1998.]
References
[1] MISO JEON Yong S K Naimur Rahman. Wnt/β-catenin signaling plays a distinct role in methyl gallate–mediated inhibition of adipogenesis[J]. Biochemical and biophysical research communications, 2016, 479 1: Pages 22-27. DOI: 10.1016/j.bbrc.2016.08.178
[2] PRASANTA K. BAG . In vivo fluid accumulation-inhibitory, anticolonization and anti-inflammatory and in vitro biofilm-inhibitory activities of methyl gallate isolated from Terminalia chebula against fluoroquinolones resistant Vibrio cholerae[J]. Microbial pathogenesis, 2019, 128: Pages 41-46. DOI: 10.1016/j.micpath.2018.12.037
[3] HEEKYUNG LEE. Methyl gallate exhibits potent antitumor activities by inhibiting tumor infiltration of CD4+CD25+ regulatory T cells.[J]. Journal of immunology, 2010: 6698-6705. DOI: 10.4049/jimmunol.1001373
[4] LUANA BARBOSA CORREA. Anti-inflammatory Effect of Methyl Gallate on Experimental Arthritis: Inhibition of Neutrophil Recruitment, Production of Inflammatory Mediators, and Activation of Macrophages[J]. Journal of Natural Products , 2016, 79 6: 1554-1566. DOI: 10.1021/acs.jnatprod.5b01115
[5] Liang, H., Huang, Q., Zou, L., Wei, P., Lu, J., Zhang, Y. (2023). Methyl gallate: Review of pharmacological activity. Pharmacological Research, 194, Article 106849. https://doi.org/10.1016/j.phrs.2023.106849
Methyl gallate Preparation Products And Raw materials
Raw materials
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View Lastest Price from Methyl gallate manufacturers
- Product
- Methyl gallate 99-24-1
- Price
- US $6.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 10000
- Release date
- 2024-09-05
- Product
- Methyl gallate 99-24-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-21
- Product
- Methyl Gallate 99-24-1
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100tons
- Release date
- 2024-06-19