Pyrimidine-2-carboxylic acid

Product Name: Pyrimidine-2-carboxylic acid
CAS No.: 31519-62-7
Chemical Name: Pyrimidine-2-carboxylic acid
Synonyms: AvafilImpurity60;TIMTEC-BB SBB005602;RARECHEM AL BO 0759;2-CARBOXY-PYRIMIDINE;Avanafil Impurity 60;2-Pyrimidinecarboxylicaci;2-PYRIMIDINECARBOXYLIC ACID;Pyrimidin-2-carboxylic acid;PYRIMIDINE-2-CARBOXYLIC ACID;2-Pyrimidinecarboxylic ac...
CBNumber: CB4766450
Molecular Formula: C5H4N2O2
Formula Weight: 124.1
MOL File: 31519-62-7.mol

More

Less

Pyrimidine-2-carboxylic acid Property

Melting point:: 182-185°C
Boiling point:: 362.6±25.0 °C(Predicted)
Density: 1.403±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Soluble in ethanol, Dimethyl sulfoxide (DMSO), Dimethylformamide (DMF), and solution of Phosphate Buffered Saline (PBS).
form: powder to crystal
pka: 3.08±0.10(Predicted)
color: White to Almost white
λmax: 246nm(H2O (pH 7))(lit.)
InChIKey: ZFCHNZDUMIOWFV-UHFFFAOYSA-N
CAS DataBase Reference: 31519-62-7(CAS DataBase Reference)

More

Less

Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36/37/39
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29335990

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 754315
Product name: Pyrimidine-2-carboxylic acid
Purity: 97%
Packaging: 1g
Price: $53.9
Updated: 2025/07/31

TCI Chemical

Product number: P2328
Product name: Pyrimidine-2-carboxylic Acid
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $81
Updated: 2023/06/20

Cayman Chemical

Product number: 10007123
Product name: 2-carboxy-Pyrimidine
Purity: ≥95%
Packaging: 500mg
Price: $26
Updated: 2024/03/01

Cayman Chemical

Product number: 10007123
Product name: 2-carboxy-Pyrimidine
Purity: ≥95%
Packaging: 1g
Price: $46
Updated: 2024/03/01

Cayman Chemical

Product number: 10007123
Product name: 2-carboxy-Pyrimidine
Purity: ≥95%
Packaging: 5g
Price: $285
Updated: 2023/01/06

More

Less

Pyrimidine-2-carboxylic acid Chemical Properties,Usage,Production

Description

2-carboxy-Pyrimidine is a synthetic intermediate useful for pharmaceutical synthesis.

Chemical Properties

White to off-white solid

Uses

2-carboxy-Pyrimidine is a synthetic intermediate.

Synthesis

14080-23-0

31519-62-7

Synthesis of pyrimidine-2-carboxylic acid (11): pyrimidine-2-carbonitrile (10) (201 mg, 1.914 mmol) was dissolved in water (5 mL) under stirring conditions, followed by addition of KOH (214.3 mg, 3.83 mmol). The reaction mixture was heated to reflux for 3 hours. The progress of the reaction was monitored by thin layer chromatography (TLC) and after confirming the complete consumption of raw materials, the reaction mixture was slowly cooled to room temperature. The reaction mixture was neutralized with 2N HCl solution and subsequently the aqueous phase was removed by rotary evaporation to give the crude product. The crude product was extracted with ethyl acetate (EtOAc), the organic phases were combined and filtered through a diatomaceous earth pad. The filtrate was concentrated under reduced pressure to afford pyrimidine-2-carboxylic acid (11) (84 mg, 35.4% yield), which could be used in subsequent reactions without further purification.TLC conditions: 80% EtOAc/hexane (Rf: 0.05).1H NMR (400 MHz, CD3OD-d4): δ 8.83 (br s, 2H), 7.47 (t, J = 4.8 Hz, 1H).

References

[1] Dalton Transactions, 2011, vol. 40, # 20, p. 5476 - 5482
[2] Journal of Organic Chemistry, 2015, vol. 80, # 5, p. 2676 - 2699
[3] Chemical Communications, 2016, vol. 52, # 54, p. 8459 - 8462
[4] Patent: WO2013/13238, 2013, A2. Location in patent: Page/Page column 49
[5] Patent: KR2015/128789, 2015, A. Location in patent: Paragraph 0818; 0820; 0821

Pyrimidine-2-carboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Pyrimidine-2-carboxylic acid Suppliers

China 180 Czech Republic 1 Europe 1 Germany 3 India 3 Japan 1 Switzerland 1 United Kingdom 7 United States 34 Global 231

Chengdu Forest Science and Technology Development Co., Ltd.

Tel: 18030648795
Fax: 028-61777050
Email: sales@cdforestchem.com
Country: China
ProdList: 1998
Advantage: 58

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15838
Advantage: 69

Bridge Organics

Tel: +1269-649-4200
Fax: +1269-649-0611
Email: ab@bridgeorganics.com
Country: United States
ProdList: 162
Advantage: 55

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
Advantage: 66

Beijing Ouhe Technology Co., Ltd

Tel: 010-010-82967028 13522913783
Fax: +86-10-82967029
Email: 2355560935@qq.com
Country: China
ProdList: 12000
Advantage: 60

Pure Chemistry Scientific Inc.

Tel: 001-857-928-2050 or 1-888-588-9418
Fax: 001-617-206-9595
Email: sales@chemreagents.com
Country: United States
ProdList: 10186
Advantage: 62

More

Less

View Lastest Price from Pyrimidine-2-carboxylic acid manufacturers

Dideu Industries Group Limited

Product: Pyrimidine-2-carboxylic acid 31519-62-7
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons
Release date: 2022-02-17

Zhuozhou Wenxi import and Export Co., Ltd

Product: 2-Pyrimidinecarboxylic acid 31519-62-7
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: 2-Pyrimidinecarboxylic acid 31519-62-7
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-08

31519-62-7, Pyrimidine-2-carboxylic acidRelated Search:

Sulfadiazine Silver sulfadiazine Ethyl 2-(Chlorosulfonyl)acetate Uracil Pyrimidine Cytosine Fluorocytosine 9-Fluorenylmethyl chloroformate Octyl gallate 2-Pyrimidinecarboxaldehyde 2-Pyrimidinecarboxamide (6CI,7CI,9CI) Pyrimidine-5-boronic acid pinacol ester 5-Pyrimidinecarboxylic acid PYRIMIDINE-4-CARBOXALDEHYDE Pyrimidine-5-carboxaldehyde Pyrrole-2-carboxaldehyde PYRROLE-2-CARBONITRILE Pyrrole-2-carboxylic acid

PYRIMIDINE-2-CARBOXYLIC ACID

RARECHEM AL BO 0759

TIMTEC-BB SBB005602

2-PYRIMIDINECARBOXYLIC ACID

2-CARBOXY-PYRIMIDINE

2-Pyrimidinecarboxylic acid (6CI,8CI,9CI)

2-Pyrimidinecarboxylic acid(Crystalline solid)

Pyrimidine-2-carboxylic acid 98%

2-Pyrimidinecarboxylic ac...

2-Carboxypyrimidine, 2-Carboxy-1,3-diazine

Pyrimidine-2-carboxylicacid,97%

2-Pyrimidine-carboxylic acid, >=98%

Avanafil Impurity 60

2-Pyrimidinecarboxylicaci

Pyrimidine-2-carboxylic acid ISO 9001：2015 REACH

AvafilImpurity60

Pyrimidin-2-carboxylic acid

31519-62-7

APIs & Intermediate

pharmacetical

Carboxylic Acids

Pyrazines, Pyrimidines & Pyridazines

API intermediates

PYRIMIDINE

Heterocycle-Pyrimidine series

Carboxylic Acids

Pyrazines, Pyrimidines & Pyridazines