Pyrimidine-2-carboxylic acid
- Product Name
- Pyrimidine-2-carboxylic acid
- CAS No.
- 31519-62-7
- Chemical Name
- Pyrimidine-2-carboxylic acid
- Synonyms
- AvafilImpurity60;TIMTEC-BB SBB005602;RARECHEM AL BO 0759;2-CARBOXY-PYRIMIDINE;Avanafil Impurity 60;2-Pyrimidinecarboxylicaci;2-PYRIMIDINECARBOXYLIC ACID;Pyrimidin-2-carboxylic acid;PYRIMIDINE-2-CARBOXYLIC ACID;2-Pyrimidinecarboxylic ac...
- CBNumber
- CB4766450
- Molecular Formula
- C5H4N2O2
- Formula Weight
- 124.1
- MOL File
- 31519-62-7.mol
Pyrimidine-2-carboxylic acid Property
- Melting point:
- 182-185°C
- Boiling point:
- 362.6±25.0 °C(Predicted)
- Density
- 1.403±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- Soluble in ethanol, Dimethyl sulfoxide (DMSO), Dimethylformamide (DMF), and solution of Phosphate Buffered Saline (PBS).
- form
- powder to crystal
- pka
- 3.08±0.10(Predicted)
- color
- White to Almost white
- λmax
- 246nm(H2O (pH 7))(lit.)
- InChIKey
- ZFCHNZDUMIOWFV-UHFFFAOYSA-N
- CAS DataBase Reference
- 31519-62-7(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29335990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 754315
- Product name
- Pyrimidine-2-carboxylic acid
- Purity
- 97%
- Packaging
- 1g
- Price
- $53.9
- Updated
- 2025/07/31
- Product number
- P2328
- Product name
- Pyrimidine-2-carboxylic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $81
- Updated
- 2023/06/20
- Product number
- 10007123
- Product name
- 2-carboxy-Pyrimidine
- Purity
- ≥95%
- Packaging
- 500mg
- Price
- $26
- Updated
- 2024/03/01
- Product number
- 10007123
- Product name
- 2-carboxy-Pyrimidine
- Purity
- ≥95%
- Packaging
- 1g
- Price
- $46
- Updated
- 2024/03/01
- Product number
- 10007123
- Product name
- 2-carboxy-Pyrimidine
- Purity
- ≥95%
- Packaging
- 5g
- Price
- $285
- Updated
- 2023/01/06
Pyrimidine-2-carboxylic acid Chemical Properties,Usage,Production
Description
2-
Chemical Properties
White to off-white solid
Uses
2-carboxy-Pyrimidine is a synthetic intermediate.
Synthesis
14080-23-0
31519-62-7
Synthesis of pyrimidine-2-carboxylic acid (11): pyrimidine-2-carbonitrile (10) (201 mg, 1.914 mmol) was dissolved in water (5 mL) under stirring conditions, followed by addition of KOH (214.3 mg, 3.83 mmol). The reaction mixture was heated to reflux for 3 hours. The progress of the reaction was monitored by thin layer chromatography (TLC) and after confirming the complete consumption of raw materials, the reaction mixture was slowly cooled to room temperature. The reaction mixture was neutralized with 2N HCl solution and subsequently the aqueous phase was removed by rotary evaporation to give the crude product. The crude product was extracted with ethyl acetate (EtOAc), the organic phases were combined and filtered through a diatomaceous earth pad. The filtrate was concentrated under reduced pressure to afford pyrimidine-2-carboxylic acid (11) (84 mg, 35.4% yield), which could be used in subsequent reactions without further purification.TLC conditions: 80% EtOAc/hexane (Rf: 0.05).1H NMR (400 MHz, CD3OD-d4): δ 8.83 (br s, 2H), 7.47 (t, J = 4.8 Hz, 1H).
References
[1] Dalton Transactions, 2011, vol. 40, # 20, p. 5476 - 5482
[2] Journal of Organic Chemistry, 2015, vol. 80, # 5, p. 2676 - 2699
[3] Chemical Communications, 2016, vol. 52, # 54, p. 8459 - 8462
[4] Patent: WO2013/13238, 2013, A2. Location in patent: Page/Page column 49
[5] Patent: KR2015/128789, 2015, A. Location in patent: Paragraph 0818; 0820; 0821
Pyrimidine-2-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
Pyrimidine-2-carboxylic acid Suppliers
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- Country
- Germany
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View Lastest Price from Pyrimidine-2-carboxylic acid manufacturers
- Product
- Pyrimidine-2-carboxylic acid 31519-62-7
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons
- Release date
- 2022-02-17
- Product
- 2-Pyrimidinecarboxylic acid 31519-62-7
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- 2-Pyrimidinecarboxylic acid 31519-62-7
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-08