ChemicalBook > CAS DataBase List > 3,5-Dichloro-4-hydroxybenzoic acid
3,5-Dichloro-4-hydroxybenzoic acid
- Product Name
- 3,5-Dichloro-4-hydroxybenzoic acid
- CAS No.
- 3336-41-2
- Chemical Name
- 3,5-Dichloro-4-hydroxybenzoic acid
- Synonyms
- AKOS BBS-00006921;RARECHEM AL BE 0933;Dotinurad Impurity 34;Dotinurad Impurity 24;LABOTEST-BB LT00454970;Tetrahydrozoline Impurity 4;3,5-dichloro-4-hydroxybenzoate;3,5-dichloro-4-hydroxy-benzoicaci;,5-Dichloro-4-hydroxybenzoic acid;3,5-DICHLORO-4-HYDROXYBENZOIC ACID
- CBNumber
- CB0480631
- Molecular Formula
- C7H4Cl2O3
- Formula Weight
- 207.01
- MOL File
- 3336-41-2.mol
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3,5-Dichloro-4-hydroxybenzoic acid Property
- Melting point:
- 264-266 °C (lit.)
- Boiling point:
- 297.29°C (rough estimate)
- Density
- 1.5281 (rough estimate)
- refractive index
- 1.4845 (estimate)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 3.83±0.10(Predicted)
- color
- White to Off-White
- BRN
- 2616297
- InChI
- InChI=1S/C7H4Cl2O3/c8-4-1-3(7(11)12)2-5(9)6(4)10/h1-2,10H,(H,11,12)
- InChIKey
- AULKDLUOQCUNOK-UHFFFAOYSA-N
- SMILES
- C(O)(=O)C1=CC(Cl)=C(O)C(Cl)=C1
- CAS DataBase Reference
- 3336-41-2(CAS DataBase Reference)
- NIST Chemistry Reference
- 3,5-Dichloro-4-hydroxybenzoic acid(3336-41-2)
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- D64007
- Product name
- 3,5-Dichloro-4-hydroxybenzoic acid
- Purity
- 97%
- Packaging
- 25g
- Price
- $111
- Updated
- 2023/06/20
TCI Chemical
- Product number
- D0373
- Product name
- 3,5-Dichloro-4-hydroxybenzoic Acid
- Purity
- >98.0%(T)
- Packaging
- 5g
- Price
- $28
- Updated
- 2025/07/31
TCI Chemical
- Product number
- D0373
- Product name
- 3,5-Dichloro-4-hydroxybenzoic Acid
- Purity
- >98.0%(T)
- Packaging
- 25g
- Price
- $77
- Updated
- 2025/07/31
TRC
- Product number
- D438698
- Product name
- 3,5-Dichloro-4-hydroxybenzoic acid
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 082034
- Product name
- 3,5-Dichloro-4-hydroxybenzoic acid
- Purity
- 95%
- Packaging
- 25g
- Price
- $49
- Updated
- 2021/12/16
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3,5-Dichloro-4-hydroxybenzoic acid Chemical Properties,Usage,Production
Chemical Properties
White to light yellow crystal powder
Uses
3,5-Dichloro-4-hydroxybenzoic Acid can be used as cyclin dependent kinase inhibitors to treat cell proliferative disorders, such as, cancer.
Definition
ChEBI: 3,5-dichloro-4-hydroxybenzoic acid is a derivative of p-salicylic acid with chloro- substituents at C-3 and C-5 of the benzene ring. It is a monohydroxybenzoic acid and a dichlorobenzene. It is functionally related to a benzoic acid and a 4-hydroxybenzoic acid. It is a conjugate acid of a 3,5-dichloro-4-hydroxybenzoate.
Synthesis
99-96-7
3336-41-2
The general procedure for the synthesis of 3,5-dichloro-4-hydroxybenzoic acid from 4-hydroxybenzoic acid was as follows: 10 mL of 33% hydrogen peroxide solution was slowly added to a suspension of 10 mL hydrochloric acid and 20 mL water containing 3.5 g (0.025 mol) of 4-hydroxybenzoic acid. Upon completion of the reaction, the resulting white precipitate was collected by filtration, washed well with hot water and purified by recrystallization from ethanol. Finally, 3.19 g of white crystalline product was obtained in 63.5% yield with a melting point of 265 °C. The 1H NMR spectral data of the product was as follows (ppm): 7.84 (s, 2H, H2,6). Elemental analysis results: measured values (%) C 40.64, H 1.87, Cl 34.34; calculated values (%) C 40.58, H 1.93, Cl 34.30 (molecular formula: C7H4Cl2O2).
References
[1] Organic Process Research and Development, 1999, vol. 3, # 1, p. 10 - 16
[2] Russian Journal of General Chemistry, 2015, vol. 85, # 3, p. 577 - 583
[3] Zh. Obshch. Khim., 2015, vol. 85, # 3, p. 413 - 419,7
[4] Zhurnal Obshchei Khimii, 1949, vol. 19, p. 1167,1168
[5] Chem. Zentralbl., 1950, vol. 121, p. 1063
3,5-Dichloro-4-hydroxybenzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3,5-Dichloro-4-hydroxybenzoic acid manufacturers
ShenZhen H&D Pharmaceutical Technology Co., LTD
- Product
- Dotinurad Impurity 34 3336-41-2
- Price
- US $0.00/mg
- Min. Order
- 10mg
- Purity
- 0.98
- Supply Ability
- 5g
- Release date
- 2025-05-29
Shaanxi Dideu New Materials Co. Ltd
- Product
- 3,5-Dichloro-4-hydroxybenzoic acid 3336-41-2
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2025-03-18
Shaanxi Dideu Medichem Co. Ltd
- Product
- 3,5-Dichloro-4-hydroxybenzoic acid 3336-41-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2024-07-11
3336-41-2, 3,5-Dichloro-4-hydroxybenzoic acidRelated Search:
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