Imidazo[1,5-a]pyrazine, 5,6,7,8-tetrahydro- (9CI)
- Product Name
- Imidazo[1,5-a]pyrazine, 5,6,7,8-tetrahydro- (9CI)
- CAS No.
- 297172-19-1
- Chemical Name
- Imidazo[1,5-a]pyrazine, 5,6,7,8-tetrahydro- (9CI)
- Synonyms
- 5H,6H,7H,8H-imidazo[1,5-a]pyrazine;4H,5H,6H,7H-iMidazo[1,5-a]pyrazine;5,6,7,8-tetrahydroimidazo[1,5-A]pyrazin;IMidazo[1,5-a]pyrazine, 5,6,7,8-tetrahydro-;1,5,6,7,8,8a-hexahydroimidazo[1,5-a]pyrazine;5,6,7,8-Tetrahydroimidazolo[1,5-a]piperazine;Imidazo[1,5-a]pyrazine, 5,6,7,8-tetrahydro- (9CI);5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine - [T31668];5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine(SALTDATA: 2HCl)
- CBNumber
- CB01057584
- Molecular Formula
- C6H9N3
- Formula Weight
- 123.16
- MOL File
- 297172-19-1.mol
Imidazo[1,5-a]pyrazine, 5,6,7,8-tetrahydro- (9CI) Property
- Boiling point:
- 340.0±30.0 °C(Predicted)
- Density
- 1.33±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- pka
- 8.26±0.20(Predicted)
- form
- solid
- color
- Cream
- CAS DataBase Reference
- 297172-19-1
Safety
- HS Code
- 2933299090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- T796273
- Product name
- 5,6,7,8-Tetrahydroimidazo[1,5-A]pyrazine
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- T796273
- Product name
- 5,6,7,8-Tetrahydroimidazo[1,5-A]pyrazine
- Packaging
- 50mg
- Price
- $155
- Updated
- 2021/12/16
- Product number
- OR928290
- Product name
- 5,6,7,8-Tetrahydroimidazo[1,5-a]pyrazine
- Purity
- 96%
- Packaging
- 250mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- T31668
- Product name
- 5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine
- Purity
- 97%
- Packaging
- 1g
- Price
- $190
- Updated
- 2021/12/16
- Product number
- 3H31-1-AT
- Product name
- 5,6,7,8-Tetrahydroimidazo[1,5-a]pyrazine
- Purity
- 96%
- Packaging
- 250mg
- Price
- $240
- Updated
- 2021/12/16
Imidazo[1,5-a]pyrazine, 5,6,7,8-tetrahydro- (9CI) Chemical Properties,Usage,Production
Uses
5,6,7,8-Tetrahydroimidazo[1,5-A]pyrazine can be used as KRAS G12C inhibitors as antitumor agents.
Synthesis
165894-09-7
297172-19-1
GENERAL STEPS: 7-Benzyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine (4.89 g, 22.9 mmol) was dissolved in anhydrous ethanol (200 mL) and 10% palladium carbon catalyst (4.88 g) was added. The reaction mixture was placed under 1 bar hydrogen atmosphere and the reaction was vigorously stirred at room temperature overnight. Upon completion of the reaction, the catalyst was removed by filtration through a diatomaceous earth pad and the filter cake was washed with ethanol. The filtrates were combined, concentrated under reduced pressure and subsequently co-evaporated with dichloromethane to completely remove the residual solvent to afford the target compound 5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine as an off-white oil (2.52 g). The product was characterized by 1H NMR (CD3OD): δ 7.42 (s, 1H), 6.77 (s, 1H), 4.07 (s, 2H), 3.99 (t, J = 5.6 Hz, 2H), 3.22 (t, J = 5.6 Hz, 2H), 1.76 (br s, 1H). LC/MS analysis showed m/z 124 [M + H]+, which is consistent with target molecular weight.
References
[1] Patent: WO2015/91795, 2015, A1. Location in patent: Paragraph 36
Imidazo[1,5-a]pyrazine, 5,6,7,8-tetrahydro- (9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Imidazo[1,5-a]pyrazine, 5,6,7,8-tetrahydro- (9CI) manufacturers
- Product
- Imidazo[1,5-a]pyrazine, 5,6,7,8-tetrahydro- (9CI) 297172-19-1
- Price
- US $6.60/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg-1000kg
- Release date
- 2019-12-25