ChemicalBook > CAS DataBase List > Imidazo[1,5-a]pyrazine, 5,6,7,8-tetrahydro- (9CI)

Imidazo[1,5-a]pyrazine, 5,6,7,8-tetrahydro- (9CI)

Product Name: Imidazo[1,5-a]pyrazine, 5,6,7,8-tetrahydro- (9CI)
CAS No.: 297172-19-1
Chemical Name: Imidazo[1,5-a]pyrazine, 5,6,7,8-tetrahydro- (9CI)
Synonyms: 5H,6H,7H,8H-imidazo[1,5-a]pyrazine;4H,5H,6H,7H-iMidazo[1,5-a]pyrazine;5,6,7,8-tetrahydroimidazo[1,5-A]pyrazin;IMidazo[1,5-a]pyrazine, 5,6,7,8-tetrahydro-;1,5,6,7,8,8a-hexahydroimidazo[1,5-a]pyrazine;5,6,7,8-Tetrahydroimidazolo[1,5-a]piperazine;Imidazo[1,5-a]pyrazine, 5,6,7,8-tetrahydro- (9CI);5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine - [T31668];5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine(SALTDATA: 2HCl)
CBNumber: CB01057584
Molecular Formula: C6H9N3
Formula Weight: 123.16
MOL File: 297172-19-1.mol

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Imidazo[1,5-a]pyrazine, 5,6,7,8-tetrahydro- (9CI) Property

Boiling point:: 340.0±30.0 °C(Predicted)
Density: 1.33±0.1 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
pka: 8.26±0.20(Predicted)
form: solid
color: Cream
CAS DataBase Reference: 297172-19-1

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Safety

HS Code: 2933299090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: T796273
Product name: 5,6,7,8-Tetrahydroimidazo[1,5-A]pyrazine
Packaging: 10mg
Price: $45
Updated: 2021/12/16

TRC

Product number: T796273
Product name: 5,6,7,8-Tetrahydroimidazo[1,5-A]pyrazine
Packaging: 50mg
Price: $155
Updated: 2021/12/16

Apolloscientific

Product number: OR928290
Product name: 5,6,7,8-Tetrahydroimidazo[1,5-a]pyrazine
Purity: 96%
Packaging: 250mg
Price: $150
Updated: 2021/12/16

Synthonix

Product number: T31668
Product name: 5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine
Purity: 97%
Packaging: 1g
Price: $190
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H31-1-AT
Product name: 5,6,7,8-Tetrahydroimidazo[1,5-a]pyrazine
Purity: 96%
Packaging: 250mg
Price: $240
Updated: 2021/12/16

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Imidazo[1,5-a]pyrazine, 5,6,7,8-tetrahydro- (9CI) Chemical Properties,Usage,Production

Uses

5,6,7,8-Tetrahydroimidazo[1,5-A]pyrazine can be used as KRAS G12C inhibitors as antitumor agents.

Synthesis

165894-09-7

297172-19-1

GENERAL STEPS: 7-Benzyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine (4.89 g, 22.9 mmol) was dissolved in anhydrous ethanol (200 mL) and 10% palladium carbon catalyst (4.88 g) was added. The reaction mixture was placed under 1 bar hydrogen atmosphere and the reaction was vigorously stirred at room temperature overnight. Upon completion of the reaction, the catalyst was removed by filtration through a diatomaceous earth pad and the filter cake was washed with ethanol. The filtrates were combined, concentrated under reduced pressure and subsequently co-evaporated with dichloromethane to completely remove the residual solvent to afford the target compound 5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine as an off-white oil (2.52 g). The product was characterized by 1H NMR (CD3OD): δ 7.42 (s, 1H), 6.77 (s, 1H), 4.07 (s, 2H), 3.99 (t, J = 5.6 Hz, 2H), 3.22 (t, J = 5.6 Hz, 2H), 1.76 (br s, 1H). LC/MS analysis showed m/z 124 [M + H]+, which is consistent with target molecular weight.

References

[1] Patent: WO2015/91795, 2015, A1. Location in patent: Paragraph 36

Imidazo[1,5-a]pyrazine, 5,6,7,8-tetrahydro- (9CI) Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Imidazo[1,5-a]pyrazine, 5,6,7,8-tetrahydro- (9CI) manufacturers

Career Henan Chemical Co

Product: Imidazo[1,5-a]pyrazine, 5,6,7,8-tetrahydro- (9CI) 297172-19-1
Price: US $6.60/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 1kg-1000kg
Release date: 2019-12-25

297172-19-1, Imidazo[1,5-a]pyrazine, 5,6,7,8-tetrahydro- (9CI)Related Search:

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5,6,7,8-tetrahydroimidazo[1,5-A]pyrazin

5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine(SALTDATA: 2HCl)

4H,5H,6H,7H-iMidazo[1,5-a]pyrazine

IMidazo[1,5-a]pyrazine, 5,6,7,8-tetrahydro-

Imidazo[1,5-a]pyrazine, 5,6,7,8-tetrahydro- (9CI)

5,6,7,8-Tetrahydroimidazolo[1,5-a]piperazine

5H,6H,7H,8H-imidazo[1,5-a]pyrazine

1,5,6,7,8,8a-hexahydroimidazo[1,5-a]pyrazine

5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine - [T31668]

297172-19-1

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