ChemicalBook > CAS DataBase List > Bapotulimab
Bapotulimab
- Product Name
- Bapotulimab
- CAS No.
- 2359413-58-2
- Chemical Name
- Bapotulimab
- Synonyms
- Bapotulimab;Bapotulimab (anti-ILDR2);Research Grade Bapotulimab;Research Grade Bapotulimab (DHB96301)
- CBNumber
- CB010617007
- Formula Weight
- 0
- MOL File
- Mol file
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Bapotulimab Property
- form
- Liquid
- color
- Colorless to light yellow
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Bapotulimab Chemical Properties,Usage,Production
Uses
Bapotulimab (BAY-1905254) is a fully human IgG2 antibody targeting immunoglobulin-like domain containing receptor 2 (ILDR2). Bapotulimab has antitumor and immunosuppressive effects[1].
in vivo
Bapotulimab (BAY-1905254; 10 mg/kg; i.p.; on days 1 and 4) shows significantly increased antigen-specific T-cell proliferation and cytotoxicity[1].
| Animal Model: | 8- to 12-week-old CD45.1-expressing C57BL/6 wild-type mice injected with OT-I transgenic T cells[1] |
| Dosage: | 10 mg/kg |
| Administration: | i.p.; on days 1 and 4 |
| Result: | Showed significantly increased antigen-specific T-cell proliferation and cytotoxicity. |
References
[1] Julia Huetter, et al. Characterization of BAY 1905254, an Immune Checkpoint Inhibitor Targeting the Immunoglobulin-Like Domain Containing Receptor 2 (ILDR2). Cancer Immunol Res. 2020 Jul;8(7):895-911. DOI:10.1158/2326-6066.CIR-19-0321
Bapotulimab Preparation Products And Raw materials
Raw materials
Preparation Products
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