Rituximab
- Product Name
- Rituximab
- CAS No.
- 174722-31-7
- Chemical Name
- Rituximab
- Synonyms
- Retuxin;Rituxan;Mabthera;Mab thera;Hsdb 7455;Unii-4F4X42syq6;Immunoglobulin G1;Rituximab 13mg/ml;Rituximab USP/EP/BP;Rituximab (anti-CD20)
- CBNumber
- CB01074099
- Molecular Formula
- C6416H9874N1688O1987S44
- Formula Weight
- 0
- MOL File
- Mol file
Rituximab Property
- storage temp.
- Store at -80°C
Safety
- Hazardous Substances Data
- 174722-31-7(Hazardous Substances Data)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H372Causes damage to organs through prolonged or repeated exposure
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P314Get medical advice/attention if you feel unwell.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 1445539
- Product name
- USP mAb 001, Monoclonal IgG1
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 2MG
- Price
- $1370
- Updated
- 2024/03/01
- Product number
- 366145
- Product name
- Immunoglobulin G1
- Packaging
- 96Tests
- Price
- $809
- Updated
- 2021/12/16
- Product number
- 152699
- Product name
- Immunoglobulin G1
- Packaging
- 96Tests
- Price
- $851
- Updated
- 2021/12/16
- Product number
- BR167936
- Product name
- Rituximab - 10mg/ml solution
- Packaging
- 10mg
- Price
- $1200
- Updated
- 2021/12/16
- Product number
- BR167936
- Product name
- Rituximab - 10mg/ml solution
- Packaging
- 1mg
- Price
- $350
- Updated
- 2021/12/16
Rituximab Chemical Properties,Usage,Production
Description
Rituximab, a chimeric murine/human monoclonal antibody approved in the United States only for treating refractory or relapsed B-cell lymphomas, reacts with the CD20 antigen. It contains the complementarity determining murine anti-CD20 antibody 2B8 regions in conjunction with human kappa and IgG1 heavy-chain constant region sequences. The vector was cloned into Chinese hamster ovarian cells as the production source of immunoglobulin. Rituximab is composed of two heavy chains of 451 amino acids and two light chains of 213 amino acids with a molecular weight of 145 kD. Rituximab has a binding affinity for the CD20 antigen of approximately 8.0 nM, similar to the parent murine antibody, 2B8[1].
Uses
Antineoplastic (microtubule inhibitor); monoclonal antibody.
Uses
Rituximab is being used for Coronavirus-related infections.
brand name
Rituxan (IDEC).
Mechanism of action
Rituximab has a unique mode of action and can induce the killing of CD20+ cells via multiple mechanisms. The direct effects of rituximab include complement-mediated cytotoxicity and antibody-dependent cell-mediated cytotoxicity, and the indirect effects include structural changes, apoptosis, and sensitization of cancer cells to chemotherapy.
Clinical Use
Rituximab has seen use in transplant patients in several settings: (1) treatment of post-transplant lymphoproliferative disease (PTLD); (2) prevention of rejection; (3) ABO-incompatible transplantation; (4) treatment of rejection; (5) desensitization in HLA sensitized patients. The treatment of post-transplant lymphoproliferative disease has probably seen the greatest use of rituximab with great success. However, there is no formal indication of this use. In non-transplant patients with lymphoma, rituximab is typically combined with other chemotherapeutic agents with somewhat worse results.
Rituximab Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Rituximab manufacturers
- Product
- Rituximab 174722-31-7
- Price
- US $0.00/G
- Min. Order
- 1G
- Purity
- 98%min
- Supply Ability
- 30kg/month
- Release date
- 2023-02-08
- Product
- Rituximab 174722-31-7
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-07-01
- Product
- Rituximab 174722-31-7
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 800 ton
- Release date
- 2020-04-30