5-Bromo-3-Methoxy-Pyridine2-Carbonitrile
- Product Name
- 5-Bromo-3-Methoxy-Pyridine2-Carbonitrile
- CAS No.
- 36057-46-2
- Chemical Name
- 5-Bromo-3-Methoxy-Pyridine2-Carbonitrile
- Synonyms
- 5-Bromo-3-methoxypicolinonitrile;5-Bromo-3-Methoxy-Pyridine2-Carbonitrile;5-Bromo-3-methoxy-2-pyridinecarbonitrile;2-Pyridinecarbonitrile, 5-bromo-3-methoxy-
- CBNumber
- CB01074680
- Molecular Formula
- C7H5BrN2O
- Formula Weight
- 213.03
- MOL File
- 36057-46-2.mol
5-Bromo-3-Methoxy-Pyridine2-Carbonitrile Property
- Boiling point:
- 310.9±37.0 °C(Predicted)
- Density
- 1.65±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- solid
- pka
- -7.15±0.10(Predicted)
- Appearance
- White to yellow Solid
- InChI
- InChI=1S/C7H5BrN2O/c1-11-7-2-5(8)4-10-6(7)3-9/h2,4H,1H3
- InChIKey
- WIRVBLLSXJUOHZ-UHFFFAOYSA-N
- SMILES
- C1(C#N)=NC=C(Br)C=C1OC
N-Bromosuccinimide Price
- Product number
- ADE000496
- Product name
- 5-Bromo-3-methoxypicolinonitrile
- Purity
- Aldrich
- Packaging
- 1g
- Price
- $817
- Updated
- 2025/07/31
- Product number
- B696888
- Product name
- 5-Bromo-3-methoxy-pyridine2-carbonitrile
- Packaging
- 250mg
- Price
- $660
- Updated
- 2021/12/16
- Product number
- X2984
- Product name
- 5-Bromo-3-methoxy-pyridine2-carbonitrile
- Packaging
- 1g
- Price
- $583
- Updated
- 2021/12/16
- Product number
- 035197
- Product name
- 5-Bromo-3-methoxypicolinonitrile
- Packaging
- 250mg
- Price
- $315
- Updated
- 2021/12/16
- Product number
- HCH0036988
- Product name
- 5-BROMO-3-METHOXY-PYRIDINE 2-CARBONITRILE
- Purity
- 95.00%
- Packaging
- 250MG
- Price
- $1010.63
- Updated
- 2021/12/16
5-Bromo-3-Methoxy-Pyridine2-Carbonitrile Chemical Properties,Usage,Production
Synthesis
886373-28-0
124-41-4
36057-46-2
Sodium methanolate (2.68 g, 49.59 mmol) was added to a solution of 5-bromo-3-fluoropyridine-2-carbonitrile (2.00 g, 9.93 mmol) in tetrahydrofuran (THF, 80 mL) at room temperature. The reaction mixture was stirred at 70 °C for 3 hours. Upon completion of the reaction, the pH of the reaction mixture was adjusted to 7 with a 3 M solution of HCl. The reaction mixture was extracted with ethyl acetate (100 mL x 3). The organic phases were combined, washed with brine and dried over anhydrous sodium sulfate. The solvent was removed by concentration under reduced pressure to give 5-bromo-3-methoxypyridine-2-carbonitrile as a brown solid (2.00 g, 95% yield). Mass spectrum (MS): m/z = 213.0 [M + H]+.
References
[1] Patent: US2016/376283, 2016, A1. Location in patent: Paragraph 1219; 1220
[2] Patent: EP3275864, 2018, A1. Location in patent: Paragraph 0032; 0038; 0044; 0050; 0056; 0062
[3] Patent: WO2007/87488, 2007, A2. Location in patent: Page/Page column 24
5-Bromo-3-Methoxy-Pyridine2-Carbonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
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