ChemicalBook > CAS DataBase List > 4-chloro-2-methylquinazoline

4-chloro-2-methylquinazoline

Product Name
4-chloro-2-methylquinazoline
CAS No.
6484-24-8
Chemical Name
4-chloro-2-methylquinazoline
Synonyms
4-chloro-2-methylquinazoline;Quinazoline, 4-chloro-2-Methyl-;4-Chloro-2-methylquinazoline?New
CBNumber
CB01078981
Molecular Formula
C9H7ClN2
Formula Weight
178.62
MOL File
6484-24-8.mol
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4-chloro-2-methylquinazoline Property

Melting point:
86-88 °C
Boiling point:
211.2±23.0 °C(Predicted)
Density 
1.292±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
form 
solid
pka
1.28±0.30(Predicted)
Appearance
Off-white to yellow Solid
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Safety

HS Code 
2933599590
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
C368293
Product name
4-Chloro-2-methylquinazoline
Packaging
100mg
Price
$60
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC144201
Product name
4-Chloro-2-methylquinazoline
Packaging
500mg
Price
$70
Updated
2021/12/16
Matrix Scientific
Product number
073604
Product name
4-Chloro-2-methylquinazoline
Purity
95+%
Packaging
1g
Price
$79
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC144201
Product name
4-Chloro-2-methylquinazoline
Packaging
1g
Price
$126
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC144201
Product name
4-Chloro-2-methylquinazoline
Packaging
2g
Price
$219
Updated
2021/12/16
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4-chloro-2-methylquinazoline Chemical Properties,Usage,Production

Synthesis

1769-24-0

6484-24-8

The general procedure for the synthesis of 4-chloro-2-methylquinazoline from 4-hydroxy-2-methylquinazoline was as follows: first, starting from commercially purchased 2-methylquinazolin-4(3H)-one, the chlorination reaction was carried out at the 4-position using POCl3 according to the microwave-assisted procedure as previously reported [25], which ultimately afforded 4-chloro-2-methylquinazoline in 73% yield. Subsequently, the product was applied to the synthesis of the intermediate according to the general DMAP-catalyzed procedure described in κ 3.1.3 to give molecule 37 as a beige powder in 45% yield. The melting point of the product was 118 °C (isopropanol).1H NMR (200 MHz, CDCl3) δ = 8.33 (d, J = 8 Hz, 1H), 7.95-7.83 (m, 3H), 7.65-7.56 (m, 2H), 7.42-7.25 (m, 2H), 2.59 (s, 3H), 2.47 (s, 3H).13C NMR (50 MHz, CDCl3) δ=197.9,166.3,163.7,152.0,150.9,134.3,133.3,132.0,130.1,127.1,127.0,126.0,123.8,123.4,114.3,30.1,26.2. LC-MS (ESI+) tR 4.60 min, m/z [M+H]+ 279.19. molecular weight: 278.31 g/mol. calculated value of C17H14N2O2: C, 73.37; H, 5.07; N, 10.07. measured value: C, 73.82; H, 5.11; N, 9.93.

References

[1] Synthetic Communications, 2011, vol. 41, # 24, p. 3644 - 3653
[2] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2009, vol. 48, # 6, p. 840 - 847
[3] MedChemComm, 2013, vol. 5, # 11, p. 1700 - 1707
[4] Tetrahedron, 2014, vol. 70, # 44, p. 8257 - 8266
[5] European Journal of Medicinal Chemistry, 2016, vol. 119, p. 34 - 44

4-chloro-2-methylquinazoline Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-chloro-2-methylquinazoline manufacturers

Career Henan Chemical Co
Product
4-chloro-2-methylquinazoline 6484-24-8
Price
US $500.00-400.00/KG
Min. Order
1G
Purity
99%
Supply Ability
100KG
Release date
2018-08-03

6484-24-8, 4-chloro-2-methylquinazolineRelated Search:

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  • Quinazoline, 4-chloro-2-Methyl-
  • 4-chloro-2-methylquinazoline
  • 4-Chloro-2-methylquinazoline?New
  • 6484-24-8