4-CHLORO-2-PHENYLQUINAZOLINE
- Product Name
- 4-CHLORO-2-PHENYLQUINAZOLINE
- CAS No.
- 6484-25-9
- Chemical Name
- 4-CHLORO-2-PHENYLQUINAZOLINE
- Synonyms
- AM-ex-OL;AKOS 93518;NSC 400965;am-ex-ol tm;AM-EX-OL(R);AM-ex-OL®4-Chloro-2-phenyl-quizoline;2-Phenyl-4-chloroquinazoline;4-CHLORO-2-PHENYLQUINAZOLINE;QUINAZOLINE, 4-CHLORO-2-PHENYL-
- CBNumber
- CB6137584
- Molecular Formula
- C14H9ClN2
- Formula Weight
- 240.69
- MOL File
- 6484-25-9.mol
4-CHLORO-2-PHENYLQUINAZOLINE Property
- Melting point:
- 124-126 °C(lit.)
- Boiling point:
- 383.11°C (rough estimate)
- Density
- 1.285
- refractive index
- 1.5749 (estimate)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- form
- Crystalline Powder
- pka
- 0.67±0.30(Predicted)
- color
- Slightly yellow to yellow
- InChIKey
- OBHKONRNYCDRKM-UHFFFAOYSA-N
- CAS DataBase Reference
- 6484-25-9(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 162434
- Product name
- 4-Chloro-2-phenylquinazoline
- Purity
- 97%
- Packaging
- 5g
- Price
- $62.4
- Updated
- 2023/01/07
- Product number
- J55066
- Product name
- 4-Chloro-2-phenylquinazoline
- Packaging
- 5g
- Price
- $70
- Updated
- 2021/12/16
- Product number
- J55066
- Product name
- 4-Chloro-2-phenylquinazoline
- Packaging
- 1g
- Price
- $20
- Updated
- 2021/12/16
- Product number
- FC50857
- Product name
- 4-Chloro-2-phenylquinazoline
- Packaging
- 5G
- Price
- $100
- Updated
- 2021/12/16
- Product number
- HCH0023396
- Product name
- 4-CHLORO-2-PHENYLQUINAZOLINE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $128.1
- Updated
- 2021/12/16
4-CHLORO-2-PHENYLQUINAZOLINE Chemical Properties,Usage,Production
Chemical Properties
slightly yellow to yellow crystalline powder
Uses
Reactant involved in the synthesis of biologically active molecules including:
- Nitrotriazole amines or nitroimidazole amines for use as antitrypanosomal activity and mammalian cytotoxicity
- Quinazoline-containing piperazinylpyrimidine derivatives with antitumor activity
- Quinazoline substituted cyclopentane as HCV NS3/4A protease inhibitors
- Quinazolines with antibacterial and antitumor activity
- Aurora inhibitor MK-0457
Reactant involved in Suzuki-Miyaura cross-coupling and catalyst-free / base-free water promoted nucleophilic aromatic substitution
Uses
4-Chloro-2-phenylquinazoline can be involved in the synthesis of biologically active molecules including: Nitrotriazole amines or nitroimidazole amines for use as antitrypanosomal activity and mammalian cytotoxicity.
Synthesis Reference(s)
Journal of the American Chemical Society, 68, p. 1299, 1946 DOI: 10.1021/ja01211a055
Synthesis
1022-45-3
6484-25-9
General procedure for the synthesis of 4-chloro-2-phenylquinazoline from 4-hydroxy-2-phenylquinazoline: 4-hydroxy-2-phenylquinazoline (10 mmol) was mixed with phosphorochloridic acid (10 mL) and the reaction was stirred under reflux conditions for 9 hours. After completion of the reaction, the solvent was removed by distillation under reduced pressure. Ice water was added to the residue and neutralized with ammonium hydroxide until a precipitate was formed, followed by filtration to collect the precipitate. The product 4-chloro-2-phenylquinazoline (7) was purified by recrystallization from ethanol to give a brown solid in 68% yield. The structure of the product was determined by 1H NMR (500 MHz, DMSO-d6) δ 8.19-8.12 (m, 3H), 7.90-7.85 (m, 2H), 7.67-7.62 (m, 1H), 7.61-7.55 (m, 3H) and 13C NMR (126 MHz, DMSO-d6) δ 161.80, 153.93, 146.17, 135.15, 132.29, 131.09, 128.78, 128.50, 127.31, 126.21, 125.70, 120.75 for confirmation.
References
[1] Medicinal Chemistry Research, 2012, vol. 21, # 7, p. 1199 - 1206
[2] Acta Chimica Hungarica, 1983, vol. 113, # 3, p. 247 - 256
[3] Organic Letters, 2016, vol. 18, # 9, p. 2150 - 2153
[4] Bioorganic and Medicinal Chemistry, 2011, vol. 19, # 6, p. 1987 - 1998
[5] Bioorganic and Medicinal Chemistry, 2013, vol. 21, # 24, p. 7858 - 7873
4-CHLORO-2-PHENYLQUINAZOLINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-CHLORO-2-PHENYLQUINAZOLINE manufacturers
- Product
- 4-CHLORO-2-PHENYLQUINAZOLINE 6484-25-9
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- According to customer requirements
- Release date
- 2022-10-19
- Product
- 4-CHLORO-2-PHENYLQUINAZOLINE 6484-25-9
- Price
- US $6.68/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg-1000kg
- Release date
- 2020-01-10