1H-Isoindol-1-one, 2,3-dihydro-6-hydroxy- (9CI)
- Product Name
- 1H-Isoindol-1-one, 2,3-dihydro-6-hydroxy- (9CI)
- CAS No.
- 659737-57-2
- Chemical Name
- 1H-Isoindol-1-one, 2,3-dihydro-6-hydroxy- (9CI)
- Synonyms
- 6-hydroxyisoindolin-1-one;6-hydroxy-1-isoindolinone;6-Hydroxy-2,3-dihydro-1H-isoindol-1-one;1H-Isoindol-1-one, 2,3-dihydro-6-hydroxy-;1H-Isoindol-1-one, 2,3-dihydro-6-hydroxy- (9CI)
- CBNumber
- CB01087659
- Molecular Formula
- C8H7NO2
- Formula Weight
- 149.15
- MOL File
- 659737-57-2.mol
1H-Isoindol-1-one, 2,3-dihydro-6-hydroxy- (9CI) Property
- Boiling point:
- 507.3±50.0 °C(Predicted)
- Density
- 1.362±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 9.43±0.20(Predicted)
- form
- solid
- color
- Off-white
Safety
- HS Code
- 2933998090
N-Bromosuccinimide Price
- Product number
- H764660
- Product name
- 6-Hydroxyisoindolin-1-one
- Packaging
- 100mg
- Price
- $265
- Updated
- 2021/12/16
- Product number
- CHM0237808
- Product name
- 6-HYDROXYISOINDOLIN-1-ONE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $503.75
- Updated
- 2021/12/16
- Product number
- 0124AC
- Product name
- 6-Hydroxyisoindolin-1-one
- Packaging
- 1g
- Price
- $514
- Updated
- 2021/12/16
- Product number
- A108810
- Product name
- 6-Hydroxyisoindolin-1-one
- Purity
- 95%
- Packaging
- 100mg
- Price
- $39
- Updated
- 2021/12/16
- Product number
- A108810
- Product name
- 6-Hydroxyisoindolin-1-one
- Purity
- 95%
- Packaging
- 250mg
- Price
- $78
- Updated
- 2021/12/16
1H-Isoindol-1-one, 2,3-dihydro-6-hydroxy- (9CI) Chemical Properties,Usage,Production
Synthesis
22246-66-8
659737-57-2
5-Methoxy-2,3-dihydroisoindol-1-one (167 mg, 1.0 mmol) was used as a starting material, which was dissolved in dichloromethane (8 mL) and cooled to -78°C. Subsequently, boron tribromide (1 M in dichloromethane, 3.6 mL, 3.6 mmol) was added. The reaction mixture was slowly warmed to room temperature and stirred for 18 hours. After the reaction was complete, the mixture was cooled again to -78 °C and methanol (20 mL) was slowly added. After continued stirring at -78 °C for 2 h, the solvent was removed by evaporation. The residue was purified by silica gel column chromatography with the eluent being dichloromethane:2N ammonia methanol solution (9:1) to afford the target product 6-hydroxy-isoindolin-1-one (147 mg, 100% yield) as a white solid. Mass spectrometry analysis showed m/e = 148.0 (M-H+).
References
[1] Patent: WO2004/14856, 2004, A1. Location in patent: Page 10; 23
[2] Patent: WO2008/20306, 2008, A2. Location in patent: Page/Page column 26; 28
[3] Tetrahedron Letters, 2009, vol. 50, # 12, p. 1267 - 1269
[4] Patent: WO2008/20306, 2008, A2. Location in patent: Page/Page column 26; 28
[5] Patent: WO2006/138549, 2006, A1. Location in patent: Page/Page column 73
1H-Isoindol-1-one, 2,3-dihydro-6-hydroxy- (9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
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