ChemicalBook > CAS DataBase List > 1H-Isoindol-1-one, 2,3-dihydro-6-hydroxy- (9CI)

1H-Isoindol-1-one, 2,3-dihydro-6-hydroxy- (9CI)

Product Name: 1H-Isoindol-1-one, 2,3-dihydro-6-hydroxy- (9CI)
CAS No.: 659737-57-2
Chemical Name: 1H-Isoindol-1-one, 2,3-dihydro-6-hydroxy- (9CI)
Synonyms: 6-hydroxyisoindolin-1-one;6-hydroxy-1-isoindolinone;6-Hydroxy-2,3-dihydro-1H-isoindol-1-one;1H-Isoindol-1-one, 2,3-dihydro-6-hydroxy-;1H-Isoindol-1-one, 2,3-dihydro-6-hydroxy- (9CI)
CBNumber: CB01087659
Molecular Formula: C8H7NO2
Formula Weight: 149.15
MOL File: 659737-57-2.mol

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1H-Isoindol-1-one, 2,3-dihydro-6-hydroxy- (9CI) Property

Boiling point:: 507.3±50.0 °C(Predicted)
Density: 1.362±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 9.43±0.20(Predicted)
form: solid
color: Off-white

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC

Product number: H764660
Product name: 6-Hydroxyisoindolin-1-one
Packaging: 100mg
Price: $265
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0237808
Product name: 6-HYDROXYISOINDOLIN-1-ONE
Purity: 95.00%
Packaging: 5MG
Price: $503.75
Updated: 2021/12/16

AK Scientific

Product number: 0124AC
Product name: 6-Hydroxyisoindolin-1-one
Packaging: 1g
Price: $514
Updated: 2021/12/16

Ambeed

Product number: A108810
Product name: 6-Hydroxyisoindolin-1-one
Purity: 95%
Packaging: 5g
Price: $748
Updated: 2021/12/16

Chemcia Scientific

Product number: BB20-7024
Product name: 6-Hydroxy-2,3-dihydro-isoindol-1-one
Purity: 95%
Packaging: 5G
Price: $795
Updated: 2021/12/16

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1H-Isoindol-1-one, 2,3-dihydro-6-hydroxy- (9CI) Chemical Properties,Usage,Production

Synthesis

22246-66-8

659737-57-2

5-Methoxy-2,3-dihydroisoindol-1-one (167 mg, 1.0 mmol) was used as a starting material, which was dissolved in dichloromethane (8 mL) and cooled to -78°C. Subsequently, boron tribromide (1 M in dichloromethane, 3.6 mL, 3.6 mmol) was added. The reaction mixture was slowly warmed to room temperature and stirred for 18 hours. After the reaction was complete, the mixture was cooled again to -78 °C and methanol (20 mL) was slowly added. After continued stirring at -78 °C for 2 h, the solvent was removed by evaporation. The residue was purified by silica gel column chromatography with the eluent being dichloromethane:2N ammonia methanol solution (9:1) to afford the target product 6-hydroxy-isoindolin-1-one (147 mg, 100% yield) as a white solid. Mass spectrometry analysis showed m/e = 148.0 (M-H+).

References

[1] Patent: WO2004/14856, 2004, A1. Location in patent: Page 10; 23
[2] Patent: WO2008/20306, 2008, A2. Location in patent: Page/Page column 26; 28
[3] Tetrahedron Letters, 2009, vol. 50, # 12, p. 1267 - 1269
[4] Patent: WO2008/20306, 2008, A2. Location in patent: Page/Page column 26; 28
[5] Patent: WO2006/138549, 2006, A1. Location in patent: Page/Page column 73

1H-Isoindol-1-one, 2,3-dihydro-6-hydroxy- (9CI) Preparation Products And Raw materials

Raw materials

Preparation Products

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659737-57-2, 1H-Isoindol-1-one, 2,3-dihydro-6-hydroxy- (9CI)Related Search:

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1H-Isoindol-1-one, 2,3-dihydro-6-hydroxy- (9CI)

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