3-Methyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole

Product Name: 3-Methyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole
CAS No.: 936250-20-3
Chemical Name: 3-Methyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole
Synonyms: 5-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole;5-Methylpyrazole-4-boronic acid, pinacol ester;5-Methylpyr;3-Methyl-4-(4;3-Methyl-4-pyrazole boronic acid pinacol ester;3-Methyl-1H-pyrazole-4-boronic acid pinacol ester;3-Methyl-1H-pyrazole-4-boronicacid,pinacolester96%;(3-METHYL-1H-PYRAZOL-4-YL)BORONIC ACID PINACOL ESTER;3-Methyl-1H-pyrazole-4-boronic acid pinacol ester 97%;5-Methyl-1H-pyrazole-4-boronic acid, pinacol ester 96%
CBNumber: CB01113235
Molecular Formula: C10H17BN2O2
Formula Weight: 208.07
MOL File: 936250-20-3.mol

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3-Methyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole Property

Melting point:: 129-134℃
Boiling point:: 350.3±30.0 °C(Predicted)
Density: 1.07±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: solid
pka: 13.92±0.50(Predicted)
color: White
InChI: InChI=1S/C10H17BN2O2/c1-7-8(6-12-13-7)11-14-9(2,3)10(4,5)15-11/h6H,1-5H3,(H,12,13)
InChIKey: MSJAEFFWTBMIKT-UHFFFAOYSA-N
SMILES: N1C=C(B2OC(C)(C)C(C)(C)O2)C(C)=N1
CAS DataBase Reference: 936250-20-3

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26
WGK Germany: 3
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 706078
Product name: 3-Methyl-1H-pyrazole-4-boronic acid pinacol ester
Purity: 97%
Packaging: 250mg
Price: $114.77
Updated: 2025/07/31

Sigma-Aldrich

Product number: 706078
Product name: 3-Methyl-1H-pyrazole-4-boronic acid pinacol ester
Purity: 97%
Packaging: 1g
Price: $288.97
Updated: 2025/07/31

TRC

Product number: B486048
Product name: 3-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
Packaging: 100mg
Price: $75
Updated: 2021/12/16

Usbiological

Product number: 283459
Product name: 3-Methyl-1H-pyrazole-4-boronic acid pinacol ester
Packaging: 250mg
Price: $442
Updated: 2021/12/16

Matrix Scientific

Product number: 101699
Product name: 3-Methyl-1H-pyrazole-4-boronic acid pinacol ester
Purity: 98%
Packaging: 5g
Price: $624
Updated: 2021/12/16

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3-Methyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole Chemical Properties,Usage,Production

Chemical Properties

Solid

Uses

suzuki reaction

Synthesis

1021919-24-3

73183-34-3

936250-20-3

The general procedure for the synthesis of 3-methylpyrazole-4-boronic acid pinacol ester from 4-bromo-3-methyl-1H-pyrazole-1-carboxylic acid tert-butyl ester and pinacol ester of bis-boronic acid is as follows: 1. tert-butyl 4-bromo-3-methyl-1H-pyrazole-1-carboxylate (0.48 g, 1.84 mmol), bis(pinacolato)diboron (0.535 g, 2.1 mmol), dichloro[1,1'-bis(diphenylphosphino)ferrocene]palladium(II) dichloromethane adduct (0.156 g, 0.19 mmol), and potassium acetate ( 0.56 g, 5.7 mmol) were added sequentially to a sealed tube. 2. Add DMSO (5 mL) as a solvent to ensure that all solids are fully dissolved. 3. Flush the reaction system with nitrogen to remove oxygen and subsequently seal the reaction tube. 4. Heat the reaction mixture to 90°C and maintain this temperature for 18 hours. 5. 5. Upon completion of the reaction, the solvent was removed and the crude product was purified by silica gel column chromatography (eluent: 50% ethyl acetate in hexane solution) to afford the target compound, 3-methylpyrazole-4-boronic acid pinacol ester (0.2 g, 50% yield). 6. The structure of the product was confirmed by mass spectrometry (ESI), m/z 209.1 [M + 1]+.

References

[1] Patent: WO2008/51493, 2008, A2. Location in patent: Page/Page column 181
[2] Patent: US2013/123281, 2013, A1. Location in patent: Paragraph 0127

3-Methyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole Preparation Products And Raw materials

Raw materials

Preparation Products

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3-Methyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole Suppliers

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View Lastest Price from 3-Methyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 3-Methyl-1H-pyrazole-4-boronic acid pinacol ester 936250-20-3
Price: US $3.00-9.00/KG
Min. Order: 0.1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2025-07-05

Zhuozhou Wenxi import and Export Co., Ltd

Product: 3-Methyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole 936250-20-3
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: 3-Methyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole 936250-20-3
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

936250-20-3, 3-Methyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazoleRelated Search:

Boric acid 1-(2,2-DIMETHOXY-ETHYL)-3,5-DIMETHYL-4-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)-1H-PYRAZOLE 5-METHYL-1-PHENYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-PYRAZOLE 1,5-Dimethyl-1H-pyrazole-4-boronic acid,pinacol ester 1,3-Dimethyl-1H-pyrazole-4-boronic acid,pinacol ester 1-TERT-BUTOXYCARBONYL-3,5-DIMETHYLPYRAZOLE-4-BORONIC ACID, PINACOL ESTER 1,3,5-TRIMETHYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-PYRAZOLE 5-AMINO-3-METHYLPYRAZOLE-4-BORONIC ACID PINACOL ESTER 3-Methyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole

3-Methyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole

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3-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-...

936250-20-3 3-Methyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole

3-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1

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2-?Methyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole

3-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole - [M10036]

936250-20-3