1,3-Dimethyl-1H-pyrazole-4-boronic acid,pinacol ester

Product Name: 1,3-Dimethyl-1H-pyrazole-4-boronic acid,pinacol ester
CAS No.: 1046832-21-6
Chemical Name: 1,3-Dimethyl-1H-pyrazole-4-boronic acid,pinacol ester
Synonyms: 3-Dimethyl-4-(4;Dimethyl-1,3-DiMethylpyrazole-4-boronic acid pinacol ester;1,3-DiMethyl-1H-pyrazole-4-boronic acid,pinacol este;1,3-Dimethyl-1H-pyrazole-4-boronic acid,pinacol ester;1,3-Dimethylpyrazole-4-boronic acid pinacol ester 97%;1,3-DiMethyl-1H-pyrazol-4-ylboronic acid,pinacol ester;1,3-dimethyl-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole;1,3-Dimethyl-1H-pyrazole-4-boronic acid pinacol ester - [D10043];2-(1,3-Dimethyl-4-pyrazolyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
CBNumber: CB21486450
Molecular Formula: C11H19BN2O2
Formula Weight: 222.09
MOL File: 1046832-21-6.mol

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1,3-Dimethyl-1H-pyrazole-4-boronic acid,pinacol ester Property

Melting point:: 73.0 to 77.0 °C
Boiling point:: 322.3±30.0 °C(Predicted)
Density: 1.04±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
form: powder to crystal
pka: 2.56±0.10(Predicted)
color: White to Orange to Green
InChIKey: FBNAMBTYMSWTIB-UHFFFAOYSA-N
CAS DataBase Reference: 1046832-21-6

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Safety

Hazard Codes: Xn
Risk Statements: 22-36/37/38
Safety Statements: 26-36
WGK Germany: 3
HS Code: 2933199090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 709948
Product name: 1,3-Dimethylpyrazole-4-boronic acid pinacol ester
Purity: 97%
Packaging: 1g
Price: $143
Updated: 2023/06/20

TCI Chemical

Product number: D5184
Product name: 1,3-Dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole
Purity: >97.0%(GC)(T)
Packaging: 1g
Price: $95
Updated: 2025/07/31

TRC

Product number: D479278
Product name: 1,3-Dimethyl-1H-pyrazole-4-boronicAcidPinacolEster
Packaging: 100mg
Price: $45
Updated: 2021/12/16

TRC

Product number: D479278
Product name: 1,3-Dimethyl-1H-pyrazole-4-boronicAcidPinacolEster
Packaging: 500mg
Price: $65
Updated: 2021/12/16

ChemScene

Product number: CS-W000814
Product name: 1,3-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
Purity: 99.65%
Packaging: 1g
Price: $21
Updated: 2021/12/16

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1,3-Dimethyl-1H-pyrazole-4-boronic acid,pinacol ester Chemical Properties,Usage,Production

Uses

1,3-Dimethyl-1H-pyrazole-4-boronic acid,pinacol ester

Synthesis

5775-82-6

73183-34-3

1046832-21-6

4-Bromo-1,3-dimethyl-1H-pyrazole (5.00 g, 28.60 mmol) and pinacol ester of bisboronic acid (8.71 g, 34.32 mmol) were reacted in anhydrous 1,4-dioxane (100.0 mL). Potassium acetate (5.63 g, 57.41 mmol) and Pd(dppf)Cl2-CH2Cl2 (2.38 g, 2.86 mmol) were added to the reaction system. The reaction mixture was displaced three times with nitrogen to remove air, followed by warming to 100 °C and stirring the reaction overnight. After completion of the reaction, the reaction mixture was concentrated under reduced pressure. The concentrated residue was diluted with water (30 mL) and extracted with ethyl acetate (50 mL x 3). The organic layers were combined and dried over anhydrous sodium sulfate. The obtained residue was purified by silica gel column chromatography (eluent: ethyl acetate/petroleum ether) to afford the target product 1,3-dimethylpyrazole-4-boronic acid pinacol ester as a brown viscous liquid (3.80 g, 60% yield).

References

[1] Patent: WO2015/89327, 2015, A1. Location in patent: Paragraph 0297
[2] Patent: CN108570048, 2018, A. Location in patent: Paragraph 0590; 0592-0593
[3] Patent: WO2018/169700, 2018, A1. Location in patent: Page/Page column 00343
[4] Patent: US2013/123281, 2013, A1. Location in patent: Paragraph 0127; 0128

1,3-Dimethyl-1H-pyrazole-4-boronic acid,pinacol ester Preparation Products And Raw materials

Raw materials

Preparation Products

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1,3-Dimethyl-1H-pyrazole-4-boronic acid,pinacol ester Suppliers

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View Lastest Price from 1,3-Dimethyl-1H-pyrazole-4-boronic acid,pinacol ester manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 1,3-DiMethyl-1H-pyrazole-4-boronic acid pinacol ester 1046832-21-6
Price: US $3.00-9.00/KG
Min. Order: 0.1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2025-07-05

Zhuozhou Wenxi import and Export Co., Ltd

Product: 1,3-Dimethyl-1H-pyrazole-4-boronic acid,pinacol ester 1046832-21-6
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: 1,3-Dimethyl-1H-pyrazole-4-boronic acid,pinacol ester 1046832-21-6
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

1046832-21-6, 1,3-Dimethyl-1H-pyrazole-4-boronic acid,pinacol esterRelated Search:

1,3-DIMETHYL-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-PYRAZOLE 1H-PYRAZOLE-4-BORONIC ACID 4-Pyrazoleboronic acid pinacol ester 3-Methyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole 1-TERT-BUTOXYCARBONYL-3,5-DIMETHYLPYRAZOLE-4-BORONIC ACID, PINACOL ESTER 1,3,5-TRIMETHYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-PYRAZOLE 1,3-Dimethyl-1H-pyrazole-4-boronic acid,pinacol ester 1-(2,2-DIMETHOXY-ETHYL)-3,5-DIMETHYL-4-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)-1H-PYRAZOLE

1,3-Dimethyl-1H-pyrazole-4-boronic acid,pinacol ester

1,3-Dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

1,3-DiMethyl-1H-pyrazol-4-ylboronic acid,pinacol ester

1,3-Dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole, 2-(1,3-Dimethyl-1H-pyrazol-4-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

1,3-DiMethylpyrazole-4-boronic acid pinacol ester

1,3-DiMethyl-1H-pyrazole-4-boronic acid,pinacol este

1,3-diMethyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyrazole

1,3-dimethyl-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

1,3-Dimethylpyrazole-4-boronic acid pinacol ester 97%

1H-Pyrazole, 1,3-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-

2-(1,3-Dimethyl-4-pyrazolyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

3-Dimethyl-4-(4

Dimethyl-&#8203

1,3-Dimethyl-1H-pyrazole-4-boronic acid pinacol ester - [D10043]

1046832-21-6