4-Pyrazoleboronic acid pinacol ester

Product Name: 4-Pyrazoleboronic acid pinacol ester
CAS No.: 269410-08-4
Chemical Name: 4-Pyrazoleboronic acid pinacol ester
Synonyms: 4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-PYRAZOLE;PYRAZOLE-4-BORONIC ACID PINACOL ESTER;4-Pyrazoleboronic acid pinaol ester;4,4,5,5-TETRAMETHYL-2-(1H-PYRAZOL-4-YL)-1,3,2-DIOXABOROLANE;Baricitinib-005;Triazolam Impurity 6;eboronic acid pinacoL;Crizotinib Intermediates 4;Pinacol Pyrazol-4-ylboronate;4-PYRAZOLEBORONIC ACID PINACOL ESTER
CBNumber: CB6449821
Molecular Formula: C9H15BN2O2
Formula Weight: 194.04
MOL File: 269410-08-4.mol

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4-Pyrazoleboronic acid pinacol ester Property

Melting point:: 142-146 °C (lit.)
Boiling point:: 335.4±15.0 °C(Predicted)
Density: 1.09±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: DMSO, Ethyl Acetate, Methanol
pka: 13.36±0.50(Predicted)
form: Powder
color: Off-white to tan
Water Solubility: insoluble
InChIKey: TVOJIBGZFYMWDT-UHFFFAOYSA-N
CAS DataBase Reference: 269410-08-4(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,F
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
Hazard Note: Irritant/Flammable
TSCA: No
HS Code: 29331990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 525057
Product name: 4-Pyrazoleboronic acid pinacol ester
Purity: 97%
Packaging: 1g
Price: $21.16
Updated: 2024/03/01

Sigma-Aldrich

Product number: 525057
Product name: 4-Pyrazoleboronic acid pinacol ester
Purity: 97%
Packaging: 5g
Price: $76.5
Updated: 2024/03/01

TCI Chemical

Product number: T2756
Product name: 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole
Purity: >97.0%(GC)
Packaging: 1g
Price: $42
Updated: 2024/03/01

TCI Chemical

Product number: T2756
Product name: 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole
Purity: >97.0%(GC)
Packaging: 5g
Price: $140
Updated: 2024/03/01

Alfa Aesar

Product number: L19654
Product name: 1H-Pyrazole-4-boronic acid pinacol ester, 98%
Packaging: 1g
Price: $68.65
Updated: 2024/03/01

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4-Pyrazoleboronic acid pinacol ester Chemical Properties,Usage,Production

Chemical Properties

Off-white to tan powder

Uses

4-Pyrazoleboronic Acid Pinacol Ester is used in the preparation of Rho kinase (ROCK) inhibitors as wella s other biologically active compounds.

Uses

1H-Pyrazole-4-boronic acid pinacol ester is a useful reagent for Suzuki-Miyaura cross-couplings as well as Ruthenium-catalyzed asymmetric hydrogenation. It is also used as reagent for preparing VEGF, Aurora, RHO (ROCK), Janus Kinase 2, c-MET, ALK, S-nitrsoflutathione reductase, CDC7, Acetyl-CoA carboxylase inhibitors as well as other biologically active compounds.

Uses

Reagent used for

Suzuki-Miyaura cross-couplings
Ruthenium-catalyzed asymmetric hydrogenation

Reagent used in preparation of inhibitors of many highly significant therapeutic enzymes and kinases containing the privileged scaffold pyrazole, including

VEGF
Aurora
Rho (ROCK)
Janus Kinase 2 (JAK)
c-MET
ALK
S-nitrosoglutathione reductase
CDC7
Acetyl-CoA carboxylase
Prosurvival Bcl-2 protein
Viral RNA-Dependent RNA polymerase
Long Chain Fatty Acid Elongase 6
PI3
AKT
Chk1
Protein Kinase B

4-Pyrazoleboronic acid pinacol ester Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Pyrazoleboronic acid pinacol ester Suppliers

Belgium 1 Canada 1 China 373 France 1 Germany 2 India 19 Japan 2 Switzerland 1 The Netherlands 1 United Kingdom 8 United States 30 Global 439

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View Lastest Price from 4-Pyrazoleboronic acid pinacol ester manufacturers

Jinan Million Pharmaceutical Co., Ltd

Product: 4-Pyrazoleboronic acid pinacol ester 269410-08-4
Price: US $2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1200KG/M
Release date: 2023-08-15

Henan Fengda Chemical Co., Ltd

Product: 4-Pyrazoleboronic acid pinacol ester 269410-08-4
Price: US $34.00-1.20/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-08

Hebei Yanxi Chemical Co., Ltd.

Product: 4-Pyrazoleboronic acid pinacol ester 269410-08-4
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99.50%
Supply Ability: 20tons
Release date: 2023-09-13

269410-08-4, 4-Pyrazoleboronic acid pinacol esterRelated Search:

Tris(trimethylsilyl)phosphate Pyraclostrobin Pinacol 5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one Pyrazole Zolpidem tartrate PROPARGYL BENZOATE 98 Propyl 4-bromo-3-methylbenzoate Propyl 3-bromo-2-chloroisonicotinate 4,4,5,5-Tetramethyl-2-(prop-1-enyl)-1,3,2-dioxaborolane Pyrazolo[1,5-a]pyridine-3-carbonitrile PYRROLO[2,1-F][1,2,4]TRIAZINE-2,4-DIAMINE Pyrido[3,4-b]pyrazine (6CI,7CI,8CI,9CI) 4-Pyridineboronic acid pinacol ester Pyridine, 2-chloro-5-(5-methyl-1H-pyrazol-3-yl)- 5-Methyl-1-phenyl-1H-pyrazole-4-boronic acid pinacol ester 97%,5-METHYL-1-PHENYL-1H-PYRAZOLE-4-BORONIC ACID PINACOL ESTER Zolpidem 1-Methyl-4-pyrazole boronic acid pinacol ester

4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole,min.97%

4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole, min. 97%

4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole4-Pyrazoleboronic acid pinacol ester

4-Pyrazoleboronic acid pinacol ester,97%

4-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)pyrazole

4-Pyrazoleboronic acid pinaol ester

1H-Pyrazole, 4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-

4-(tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

4-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole, 97+% 1GR

4-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole, 97+% 5GR

(1H-Pyrazol-4-yl)boronic acid pinacol ester

4-Pyrazoleboronic acid pinacol ester, >=98%

3-hydroxy-2,3-dimethylbutan-2-yl hydrogen 1H-pyrazol-4-ylboronate

Pinacol Pyrazol-4-ylboronate

Pyrazole-4-boronic acid sorbitol ester

4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole4-Pyrazoleboronic ac

2-(1H-Pyrazol-4-yl)-4,4,5,5-tetraMethyl-1,3,2-dioxaborolane

4,4,5,5-TetraMethyl-2-(1H-pyrazol-2-yl)-1,3,2-dioxaborolane

Pyrazol-4-ylboronic Acid Pinacol Ester

PYRAZOLE-4-BORONIC ACID PINACOL ESTER

1H-PYRAZOLE-4-BORONIC ACID PINACOL ESTER

4-PYRAZOLEBORONIC ACID PINACOL ESTER

4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-PYRAZOLE

4,4,5,5-TETRAMETHYL-2-(1H-PYRAZOL-4-YL)-1,3,2-DIOXABOROLANE

2-(4-Pyrazolyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 4-Pyrazoleboronic Acid Pinacol Ester

2-(1H-Pyrazole-4-yl)-4,4,5,5-tetraMethyl-1,3,2-dioxaborolane

4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole, 97+%

4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole, 2-(1H-Pyrazol-4-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

4-Pyrazoleboronic acid pinacol ester 97%

4-pyrazolyl boronic acid pinacol ester

4,4,5,5-Tetramethyl-2-(pyrazol-4-yl)-1,3,2-dioxaborolane

4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole, 97%, for synthesis

eboronic acid pinacoL

Baricitinib-005

2-(4-Pyrazolyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABORLAN-2-YL)-1H-PYRAZOLE

Crizotinib Intermediates 4

Triazolam Impurity 6

269410-08-4

CH34C2O2BC3N2H3

C9H15BN2O2

Heteroaryl

Organometallic Reagents

Boronic Acids and Derivatives

Boronate Esters

organic or inorganic borate

Pyrazole series

API intermediates

Boronic acid

OLED materials,pharm chemical,electronic

269410-08-4