ChemicalBook > CAS DataBase List > 4-Pyrazoleboronic acid pinacol ester

4-Pyrazoleboronic acid pinacol ester

Product Name
4-Pyrazoleboronic acid pinacol ester
CAS No.
269410-08-4
Chemical Name
4-Pyrazoleboronic acid pinacol ester
Synonyms
4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-PYRAZOLE;PYRAZOLE-4-BORONIC ACID PINACOL ESTER;4-Pyrazoleboronic acid pinaol ester;4,4,5,5-TETRAMETHYL-2-(1H-PYRAZOL-4-YL)-1,3,2-DIOXABOROLANE;Baricitinib-005;Triazolam Impurity 6;eboronic acid pinacoL;Crizotinib Intermediates 4;Pinacol Pyrazol-4-ylboronate;4-Pyrazoleboronic acid pinacol
CBNumber
CB6449821
Molecular Formula
C9H15BN2O2
Formula Weight
194.04
MOL File
269410-08-4.mol
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4-Pyrazoleboronic acid pinacol ester Property

Melting point:
142-146 °C (lit.)
Boiling point:
335.4±15.0 °C(Predicted)
Density 
1.09±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
DMSO, Ethyl Acetate, Methanol
pka
13.36±0.50(Predicted)
form 
Powder
color 
Off-white to tan
Water Solubility 
insoluble
InChIKey
TVOJIBGZFYMWDT-UHFFFAOYSA-N
CAS DataBase Reference
269410-08-4(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,F
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
Hazard Note 
Irritant/Flammable
TSCA 
No
HS Code 
29331990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
525057
Product name
4-Pyrazoleboronic acid pinacol ester
Purity
97%
Packaging
1g
Price
$21.16
Updated
2024/03/01
Sigma-Aldrich
Product number
525057
Product name
4-Pyrazoleboronic acid pinacol ester
Purity
97%
Packaging
5g
Price
$76.5
Updated
2024/03/01
TCI Chemical
Product number
T2756
Product name
4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole
Purity
>97.0%(GC)
Packaging
1g
Price
$42
Updated
2024/03/01
TCI Chemical
Product number
T2756
Product name
4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole
Purity
>97.0%(GC)
Packaging
5g
Price
$140
Updated
2024/03/01
Alfa Aesar
Product number
L19654
Product name
1H-Pyrazole-4-boronic acid pinacol ester, 98%
Packaging
1g
Price
$68.65
Updated
2024/03/01
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4-Pyrazoleboronic acid pinacol ester Chemical Properties,Usage,Production

Chemical Properties

Off-white to tan powder

Uses

4-Pyrazoleboronic Acid Pinacol Ester is used in the preparation of Rho kinase (ROCK) inhibitors as wella s other biologically active compounds.

Uses

1H-Pyrazole-4-boronic acid pinacol ester is a useful reagent for Suzuki-Miyaura cross-couplings as well as Ruthenium-catalyzed asymmetric hydrogenation. It is also used as reagent for preparing VEGF, Aurora, RHO (ROCK), Janus Kinase 2, c-MET, ALK, S-nitrsoflutathione reductase, CDC7, Acetyl-CoA carboxylase inhibitors as well as other biologically active compounds.

Uses

Reagent used for

  • Suzuki-Miyaura cross-couplings
  • Ruthenium-catalyzed asymmetric hydrogenation

Reagent used in preparation of inhibitors of many highly significant therapeutic enzymes and kinases containing the privileged scaffold pyrazole, including
  • VEGF
  • Aurora
  • Rho (ROCK)
  • Janus Kinase 2 (JAK)
  • c-MET
  • ALK
  • S-nitrosoglutathione reductase
  • CDC7
  • Acetyl-CoA carboxylase
  • Prosurvival Bcl-2 protein
  • Viral RNA-Dependent RNA polymerase
  • Long Chain Fatty Acid Elongase 6
  • PI3
  • AKT
  • Chk1
  • Protein Kinase B

4-Pyrazoleboronic acid pinacol ester Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Pyrazoleboronic acid pinacol ester Suppliers

AllyChem Co., Ltd.
Tel
0411-62313318 13942603642
Fax
0411-87549748
Email
info@allychem.com
Country
China
ProdList
928
Advantage
65
Shanghai Arbor Chemical Co., Ltd.
Tel
021-60451682 15021268886
Fax
+86-21-60451682
Email
sales@arborchemical.com
Country
China
ProdList
856
Advantage
55
Aikon International Limited
Tel
025-58859352 18068836627
Fax
02557626880
Email
sales01@aikonchem.com
Country
China
ProdList
15084
Advantage
58
Hangzhou Chemtrue Bio-Tech Co.,Ltd.
Tel
0571-86828652 18857119830
Fax
0571-83522824
Email
sales@chemtrue-bio.com
Country
China
ProdList
326
Advantage
58
Suzhou You Boron Photoelectric Material Co., Ltd.
Tel
15301358979
Email
37303017@qq.com
Country
China
ProdList
499
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58
SHENZHEN PHYSTANDARD BIO-TECH CO.,LTD
Tel
0755-0755-0755-83725350 13380397412
Fax
0755-28094224
Email
3001280422@qq.com
Country
China
ProdList
10005
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58
Bayee Biotech (Anqing) Co., Ltd.
Tel
0556-5032306 18917961636
Fax
+86-556-5032307
Email
wtx@bayeebio.com
Country
China
ProdList
261
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61
Chongqing Richem Biotechnology Co., Ltd.
Tel
13983114937
Email
Qiyuanhong_rich@163.com
Country
China
ProdList
35
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58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
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View Lastest Price from 4-Pyrazoleboronic acid pinacol ester manufacturers

Jinan Million Pharmaceutical Co., Ltd
Product
4-Pyrazoleboronic acid pinacol ester 269410-08-4
Price
US $2.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1200KG/M
Release date
2023-08-15
Hubei Lidu New Material Technology Co., Ltd
Product
4-Pyrazoleboronic acid pinacol 269410-08-4
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
20TON
Release date
2024-12-11
Hubei Lidu New Material Technology Co., Ltd
Product
4-Pyrazoleboronic acid pinacol ester 269410-08-4
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
20TON
Release date
2024-12-11

269410-08-4, 4-Pyrazoleboronic acid pinacol esterRelated Search:


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  • 269410-08-4
  • CH34C2O2BC3N2H3
  • C9H15BN2O2
  • Heteroaryl
  • Organometallic Reagents
  • Boronic Acids and Derivatives
  • Boronate Esters
  • organic or inorganic borate
  • Pyrazole series
  • API intermediates
  • Boronic acid
  • OLED materials,pharm chemical,electronic
  • 269410-08-4