4-Pyrazoleboronic acid pinacol ester
- Product Name
- 4-Pyrazoleboronic acid pinacol ester
- CAS No.
- 269410-08-4
- Chemical Name
- 4-Pyrazoleboronic acid pinacol ester
- Synonyms
- 4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-PYRAZOLE;PYRAZOLE-4-BORONIC ACID PINACOL ESTER;4-Pyrazoleboronic acid pinaol ester;4,4,5,5-TETRAMETHYL-2-(1H-PYRAZOL-4-YL)-1,3,2-DIOXABOROLANE;Baricitinib-005;Triazolam Impurity 6;eboronic acid pinacoL;Crizotinib Intermediates 4;Pinacol Pyrazol-4-ylboronate;4-PYRAZOLEBORONIC ACID PINACOL ESTER
- CBNumber
- CB6449821
- Molecular Formula
- C9H15BN2O2
- Formula Weight
- 194.04
- MOL File
- 269410-08-4.mol
4-Pyrazoleboronic acid pinacol ester Property
- Melting point:
- 142-146 °C (lit.)
- Boiling point:
- 335.4±15.0 °C(Predicted)
- Density
- 1.09±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- DMSO, Ethyl Acetate, Methanol
- pka
- 13.36±0.50(Predicted)
- form
- Powder
- color
- Off-white to tan
- Water Solubility
- insoluble
- InChIKey
- TVOJIBGZFYMWDT-UHFFFAOYSA-N
- CAS DataBase Reference
- 269410-08-4(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 525057
- Product name
- 4-Pyrazoleboronic acid pinacol ester
- Purity
- 97%
- Packaging
- 1g
- Price
- $21.16
- Updated
- 2024/03/01
- Product number
- 525057
- Product name
- 4-Pyrazoleboronic acid pinacol ester
- Purity
- 97%
- Packaging
- 5g
- Price
- $76.5
- Updated
- 2024/03/01
- Product number
- T2756
- Product name
- 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole
- Purity
- >97.0%(GC)
- Packaging
- 1g
- Price
- $42
- Updated
- 2024/03/01
- Product number
- T2756
- Product name
- 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole
- Purity
- >97.0%(GC)
- Packaging
- 5g
- Price
- $140
- Updated
- 2024/03/01
- Product number
- L19654
- Product name
- 1H-Pyrazole-4-boronic acid pinacol ester, 98%
- Packaging
- 1g
- Price
- $68.65
- Updated
- 2024/03/01
4-Pyrazoleboronic acid pinacol ester Chemical Properties,Usage,Production
Chemical Properties
Off-white to tan powder
Uses
4-Pyrazoleboronic Acid Pinacol Ester is used in the preparation of Rho kinase (ROCK) inhibitors as wella s other biologically active compounds.
Uses
1H-Pyrazole-4-boronic acid pinacol ester is a useful reagent for Suzuki-Miyaura cross-couplings as well as Ruthenium-catalyzed asymmetric hydrogenation. It is also used as reagent for preparing VEGF, Aurora, RHO (ROCK), Janus Kinase 2, c-MET, ALK, S-nitrsoflutathione reductase, CDC7, Acetyl-CoA carboxylase inhibitors as well as other biologically active compounds.
Uses
Reagent used for
- Suzuki-Miyaura cross-couplings
- Ruthenium-catalyzed asymmetric hydrogenation
Reagent used in preparation of inhibitors of many highly significant therapeutic enzymes and kinases containing the privileged scaffold pyrazole, including
- VEGF
- Aurora
- Rho (ROCK)
- Janus Kinase 2 (JAK)
- c-MET
- ALK
- S-nitrosoglutathione reductase
- CDC7
- Acetyl-CoA carboxylase
- Prosurvival Bcl-2 protein
- Viral RNA-Dependent RNA polymerase
- Long Chain Fatty Acid Elongase 6
- PI3
- AKT
- Chk1
- Protein Kinase B
4-Pyrazoleboronic acid pinacol ester Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Pyrazoleboronic acid pinacol ester manufacturers
- Product
- 4-Pyrazoleboronic acid pinacol ester 269410-08-4
- Price
- US $2.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1200KG/M
- Release date
- 2023-08-15
- Product
- 4-Pyrazoleboronic acid pinacol ester 269410-08-4
- Price
- US $34.00-1.20/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-08
- Product
- 4-Pyrazoleboronic acid pinacol ester 269410-08-4
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99.50%
- Supply Ability
- 20tons
- Release date
- 2023-09-13