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4-Pyrazoleboronic acid pinacol ester

Product Name
4-Pyrazoleboronic acid pinacol ester
CAS No.
269410-08-4
Chemical Name
4-Pyrazoleboronic acid pinacol ester
Synonyms
4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-PYRAZOLE;PYRAZOLE-4-BORONIC ACID PINACOL ESTER;4-Pyrazoleboronic acid pinaol ester;4,4,5,5-TETRAMETHYL-2-(1H-PYRAZOL-4-YL)-1,3,2-DIOXABOROLANE;Baricitinib-005;Triazolam Impurity 6;eboronic acid pinacoL;Crizotinib Intermediates 4;Pinacol Pyrazol-4-ylboronate;4-Pyrazoleboronic acid pinacol
CBNumber
CB6449821
Molecular Formula
C9H15BN2O2
Formula Weight
194.04
MOL File
269410-08-4.mol
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4-Pyrazoleboronic acid pinacol ester Property

Melting point:
142-146 °C (lit.)
Boiling point:
335.4±15.0 °C(Predicted)
Density 
1.09±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
DMSO, Ethyl Acetate, Methanol
pka
13.36±0.50(Predicted)
form 
Powder
color 
Off-white to tan
Water Solubility 
insoluble
InChIKey
TVOJIBGZFYMWDT-UHFFFAOYSA-N
CAS DataBase Reference
269410-08-4(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,F
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
Hazard Note 
Irritant/Flammable
TSCA 
No
HS Code 
29331990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
525057
Product name
4-Pyrazoleboronic acid pinacol ester
Purity
97%
Packaging
1g
Price
$21.16
Updated
2024/03/01
Sigma-Aldrich
Product number
525057
Product name
4-Pyrazoleboronic acid pinacol ester
Purity
97%
Packaging
5g
Price
$76.5
Updated
2024/03/01
TCI Chemical
Product number
T2756
Product name
4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole
Purity
>97.0%(GC)
Packaging
1g
Price
$42
Updated
2024/03/01
TCI Chemical
Product number
T2756
Product name
4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole
Purity
>97.0%(GC)
Packaging
5g
Price
$140
Updated
2024/03/01
Alfa Aesar
Product number
L19654
Product name
1H-Pyrazole-4-boronic acid pinacol ester, 98%
Packaging
1g
Price
$68.65
Updated
2024/03/01
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4-Pyrazoleboronic acid pinacol ester Chemical Properties,Usage,Production

Chemical Properties

Off-white to tan powder

Uses

4-Pyrazoleboronic Acid Pinacol Ester is used in the preparation of Rho kinase (ROCK) inhibitors as wella s other biologically active compounds.

Uses

1H-Pyrazole-4-boronic acid pinacol ester is a useful reagent for Suzuki-Miyaura cross-couplings as well as Ruthenium-catalyzed asymmetric hydrogenation. It is also used as reagent for preparing VEGF, Aurora, RHO (ROCK), Janus Kinase 2, c-MET, ALK, S-nitrsoflutathione reductase, CDC7, Acetyl-CoA carboxylase inhibitors as well as other biologically active compounds.

Uses

Reagent used for

  • Suzuki-Miyaura cross-couplings
  • Ruthenium-catalyzed asymmetric hydrogenation

Reagent used in preparation of inhibitors of many highly significant therapeutic enzymes and kinases containing the privileged scaffold pyrazole, including
  • VEGF
  • Aurora
  • Rho (ROCK)
  • Janus Kinase 2 (JAK)
  • c-MET
  • ALK
  • S-nitrosoglutathione reductase
  • CDC7
  • Acetyl-CoA carboxylase
  • Prosurvival Bcl-2 protein
  • Viral RNA-Dependent RNA polymerase
  • Long Chain Fatty Acid Elongase 6
  • PI3
  • AKT
  • Chk1
  • Protein Kinase B

4-Pyrazoleboronic acid pinacol ester Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Pyrazoleboronic acid pinacol ester Suppliers

Belgium 1 Canada 1 China 388 France 1 Germany 2 India 20 Japan 2 Switzerland 1 The Netherlands 1 United Kingdom 8 United States 30 Global 455
Interchim S.A.
Tel
--
Fax
--
Email
interchim@interchim.com
Country
France
ProdList
6302
Advantage
76
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View Lastest Price from 4-Pyrazoleboronic acid pinacol ester manufacturers

Jinan Million Pharmaceutical Co., Ltd
Product
4-Pyrazoleboronic acid pinacol ester 269410-08-4
Price
US $2.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1200KG/M
Release date
2023-08-15
Hubei Lidu New Material Technology Co., Ltd
Product
4-Pyrazoleboronic acid pinacol 269410-08-4
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
20TON
Release date
2024-12-11
Hubei Lidu New Material Technology Co., Ltd
Product
4-Pyrazoleboronic acid pinacol ester 269410-08-4
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
20TON
Release date
2024-12-11

269410-08-4, 4-Pyrazoleboronic acid pinacol esterRelated Search:

Tris(trimethylsilyl)phosphate Pyraclostrobin Pinacol 5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one Pyrazole Zolpidem tartrate PROPARGYL BENZOATE 98 Propyl 4-bromo-3-methylbenzoate Propyl 3-bromo-2-chloroisonicotinate 4,4,5,5-Tetramethyl-2-(prop-1-enyl)-1,3,2-dioxaborolane Pyrazolo[1,5-a]pyridine-3-carbonitrile PYRROLO[2,1-F][1,2,4]TRIAZINE-2,4-DIAMINE Pyrido[3,4-b]pyrazine (6CI,7CI,8CI,9CI) 4-Pyridineboronic acid pinacol ester Pyridine, 2-chloro-5-(5-methyl-1H-pyrazol-3-yl)- 5-Methyl-1-phenyl-1H-pyrazole-4-boronic acid pinacol ester 97%,5-METHYL-1-PHENYL-1H-PYRAZOLE-4-BORONIC ACID PINACOL ESTER Zolpidem 1-Methyl-4-pyrazole boronic acid pinacol ester

  • 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole,min.97%
  • 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole, min. 97%
  • 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole4-Pyrazoleboronic acid pinacol ester
  • 4-Pyrazoleboronic acid pinacol ester,97%
  • 4-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)pyrazole
  • 4-Pyrazoleboronic acid pinaol ester
  • 1H-Pyrazole, 4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-
  • 4-(tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
  • 4-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole, 97+% 1GR
  • 4-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole, 97+% 5GR
  • (1H-Pyrazol-4-yl)boronic acid pinacol ester
  • 4-Pyrazoleboronic acid pinacol ester, >=98%
  • 3-hydroxy-2,3-dimethylbutan-2-yl hydrogen 1H-pyrazol-4-ylboronate
  • Pinacol Pyrazol-4-ylboronate
  • Pyrazole-4-boronic acid sorbitol ester
  • 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole4-Pyrazoleboronic ac
  • 2-(1H-Pyrazol-4-yl)-4,4,5,5-tetraMethyl-1,3,2-dioxaborolane
  • 4,4,5,5-TetraMethyl-2-(1H-pyrazol-2-yl)-1,3,2-dioxaborolane
  • Pyrazol-4-ylboronic Acid Pinacol Ester
  • PYRAZOLE-4-BORONIC ACID PINACOL ESTER
  • 1H-PYRAZOLE-4-BORONIC ACID PINACOL ESTER
  • 4-PYRAZOLEBORONIC ACID PINACOL ESTER
  • 4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-PYRAZOLE
  • 4,4,5,5-TETRAMETHYL-2-(1H-PYRAZOL-4-YL)-1,3,2-DIOXABOROLANE
  • 2-(4-Pyrazolyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 4-Pyrazoleboronic Acid Pinacol Ester
  • 2-(1H-Pyrazole-4-yl)-4,4,5,5-tetraMethyl-1,3,2-dioxaborolane
  • 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole, 97+%
  • 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole, 2-(1H-Pyrazol-4-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
  • 4-Pyrazoleboronic acid pinacol ester 97%
  • 4-pyrazolyl boronic acid pinacol ester
  • 4,4,5,5-Tetramethyl-2-(pyrazol-4-yl)-1,3,2-dioxaborolane
  • 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole, 97%, for synthesis
  • eboronic acid pinacoL
  • Baricitinib-005
  • 2-(4-Pyrazolyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
  • 4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABORLAN-2-YL)-1H-PYRAZOLE
  • Crizotinib Intermediates 4
  • Triazolam Impurity 6
  • 4-Pyrazoleboronicacidpinacolester /4-Pyrazoleboronic acid pinacol ester
  • 4-Pyrazoleboronic acid pinacol
  • 269410-08-4
  • CH34C2O2BC3N2H3
  • C9H15BN2O2
  • Heteroaryl
  • Organometallic Reagents
  • Boronic Acids and Derivatives
  • Boronate Esters
  • organic or inorganic borate
  • Pyrazole series
  • API intermediates
  • Boronic acid
  • OLED materials,pharm chemical,electronic
  • 269410-08-4