(1R,4S)-N-Desmethyl Sertraline Hydrochloride
- Product Name
- (1R,4S)-N-Desmethyl Sertraline Hydrochloride
- CAS No.
- 675126-08-6
- Chemical Name
- (1R,4S)-N-Desmethyl Sertraline Hydrochloride
- Synonyms
- CS-2586;Dastroline;DSP-225289;Dasotraline HCl;Dastroline HCl salt;SEP-225289 hydrochloride;Sertraline Impurity 4 HCl;Sertraline Impurity 9 HCl;Sertraline Impurity 15 HCl;SEP-225289;DSP-225289;DASTROLINE
- CBNumber
- CB01175303
- Molecular Formula
- C16H15Cl2N.ClH
- Formula Weight
- 328.668
- MOL File
- 675126-08-6.mol
(1R,4S)-N-Desmethyl Sertraline Hydrochloride Property
- Melting point:
- 270-272°C (dec.)
- storage temp.
- Hygroscopic, -20°C Freezer, Under Inert Atmosphere
- solubility
- Methanol (Slightly)
- form
- Solid
- color
- White
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- D292105
- Product name
- (1R,4S)-N-DesmethylSertralineHydrochloride
- Packaging
- 10mg
- Price
- $1070
- Updated
- 2021/12/16
- Product number
- CS-6392
- Product name
- Dasotralinehydrochloride
- Purity
- 99.55%
- Packaging
- 25mg
- Price
- $1250
- Updated
- 2021/12/16
- Product number
- 9012
- Product name
- (1R,4S)-N-DesmethylSertralineHCl
- Packaging
- 5mg
- Price
- $2000
- Updated
- 2021/12/16
- Product number
- CS-6392
- Product name
- Dasotralinehydrochloride
- Purity
- 99.55%
- Packaging
- 50mg
- Price
- $2200
- Updated
- 2021/12/16
- Product number
- CS-6392
- Product name
- Dasotralinehydrochloride
- Purity
- 99.55%
- Packaging
- 10mg
- Price
- $660
- Updated
- 2021/12/16
(1R,4S)-N-Desmethyl Sertraline Hydrochloride Chemical Properties,Usage,Production
Chemical Properties
White Solid
Uses
A metabolite of Sertraline. Used for treatment of CNS disorders.
Uses
(1R,4S)-N-Desmethyl Sertraline Hydrochloride is a metabolite of Sertraline, Used for treatment of CNS disorders.
in vivo
Acute administration of dasotraline dose-dependently decreases the spontaneous firing rate of LC NE, VTA DA and DR 5-HT neurons through the activation of α2, D2 and 5-HT1A autoreceptors, respectively. Dasotraline predominantly inhibits the firing rate of LC NE neurons while producing only a partial decrease in VTA DA and DR 5-HT neuronal discharge. SEP-225289 is equipotent at inhibiting 5-HT and NE transporters since it prolongs to the same extent the time required for a 50% recovery of the firing activity of dorsal hippocampus CA3 pyramidal neurons from the inhibition induced by microiontophoretic application of 5-HT and NE[1]. Average dopamine and serotonin transporter occupancies increase with increasing doses of SEP-225289. Mean dopamine and serotonin transporter occupancies are 33%±11% and 2%±13%, respectively, for 8 mg; 44%±4% and 9%±10%, respectively, for 12 mg; and 49%±7% and 14%±15%, respectively, for 16 mg[2].
(1R,4S)-N-Desmethyl Sertraline Hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
(1R,4S)-N-Desmethyl Sertraline Hydrochloride Suppliers
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View Lastest Price from (1R,4S)-N-Desmethyl Sertraline Hydrochloride manufacturers
- Product
- (1R,4S)-N-Desmethyl Sertraline Hydrochloride 675126-08-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 97%-99.9%
- Supply Ability
- 100kg
- Release date
- 2019-12-26