(1R,4S)-N-Desmethyl Sertraline Hydrochloride

Product Name: (1R,4S)-N-Desmethyl Sertraline Hydrochloride
CAS No.: 675126-08-6
Chemical Name: (1R,4S)-N-Desmethyl Sertraline Hydrochloride
Synonyms: CS-2586;Dastroline;DSP-225289;Dasotraline HCl;Dastroline HCl salt;SEP-225289 hydrochloride;Sertraline Impurity 4 HCl;Sertraline Impurity 9 HCl;Sertraline Impurity 15 HCl;SEP-225289;DSP-225289;DASTROLINE
CBNumber: CB01175303
Molecular Formula: C16H15Cl2N.ClH
Formula Weight: 328.668
MOL File: 675126-08-6.mol

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(1R,4S)-N-Desmethyl Sertraline Hydrochloride Property

Melting point:: 270-272°C (dec.)
storage temp.: Hygroscopic, -20°C Freezer, Under Inert Atmosphere
solubility: Methanol (Slightly)
form: Solid
color: White

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: D292105
Product name: (1R,4S)-N-DesmethylSertralineHydrochloride
Packaging: 10mg
Price: $1070
Updated: 2021/12/16

ChemScene

Product number: CS-6392
Product name: Dasotralinehydrochloride
Purity: 99.55%
Packaging: 25mg
Price: $1250
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 9012
Product name: (1R,4S)-N-DesmethylSertralineHCl
Packaging: 5mg
Price: $2000
Updated: 2021/12/16

ChemScene

Product number: CS-6392
Product name: Dasotralinehydrochloride
Purity: 99.55%
Packaging: 50mg
Price: $2200
Updated: 2021/12/16

ChemScene

Product number: CS-6392
Product name: Dasotralinehydrochloride
Purity: 99.55%
Packaging: 10mg
Price: $660
Updated: 2021/12/16

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(1R,4S)-N-Desmethyl Sertraline Hydrochloride Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

A metabolite of Sertraline. Used for treatment of CNS disorders.

Uses

(1R,4S)-N-Desmethyl Sertraline Hydrochloride is a metabolite of Sertraline, Used for treatment of CNS disorders.

in vivo

Acute administration of dasotraline dose-dependently decreases the spontaneous firing rate of LC NE, VTA DA and DR 5-HT neurons through the activation of α2, D2 and 5-HT1A autoreceptors, respectively. Dasotraline predominantly inhibits the firing rate of LC NE neurons while producing only a partial decrease in VTA DA and DR 5-HT neuronal discharge. SEP-225289 is equipotent at inhibiting 5-HT and NE transporters since it prolongs to the same extent the time required for a 50% recovery of the firing activity of dorsal hippocampus CA3 pyramidal neurons from the inhibition induced by microiontophoretic application of 5-HT and NE^[1]. Average dopamine and serotonin transporter occupancies increase with increasing doses of SEP-225289. Mean dopamine and serotonin transporter occupancies are 33%±11% and 2%±13%, respectively, for 8 mg; 44%±4% and 9%±10%, respectively, for 12 mg; and 49%±7% and 14%±15%, respectively, for 16 mg^[2].

(1R,4S)-N-Desmethyl Sertraline Hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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(1R,4S)-N-Desmethyl Sertraline Hydrochloride Suppliers

Canada 1 China 53 India 3 United Kingdom 1 United States 7 Global 65

J & K SCIENTIFIC LTD.

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ShangHai Biochempartner Co.,Ltd

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View Lastest Price from (1R,4S)-N-Desmethyl Sertraline Hydrochloride manufacturers

Career Henan Chemical Co

Product: (1R,4S)-N-Desmethyl Sertraline Hydrochloride 675126-08-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 97%-99.9%
Supply Ability: 100kg
Release date: 2019-12-26

675126-08-6, (1R,4S)-N-Desmethyl Sertraline HydrochlorideRelated Search:

Trimethylamine hydrochloride Sertraline hydrochloride Sertraline

Dastroline HCl salt

DSP-225289

SEP-225289;DSP-225289;DASTROLINE

CS-2586

(1R,4S)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine Hydrochlorid

(1R,4S)-N-Desmethyl Sertraline Hydrochloride

(1R,4S)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine Hydrochloride

Dastroline

SEP-225289 hydrochloride

(1R,4S)-N-Desmethyl sertraline HCl

Sertraline Impurity 4 HCl

(1R,4S)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-amine hydrochloride

Dasotraline HCl

Dasotraline,Dopamine Transporter,inhibit,Dasotraline hydrochloride,Inhibitor,SERT,SEP-225289,SLC6A4,SEP 225289,5-HTT,DAT,Serotonin Transporter,SEP225289,SLC6A3

Sertraline Impurity 15 HCl

Sertraline Impurity 4 HCl （trans）

Sertraline Impurity 9 HCl

Dasotraline hydrochloride, 10 mM in DMSO

675126-08-6

Drug Analogues

Intermediates & Fine Chemicals

Metabolites & Impurities

Pharmaceuticals