Artemisinin-d3
- Product Name
- Artemisinin-d3
- CAS No.
- 176652-07-6
- Chemical Name
- Artemisinin-d3
- Synonyms
- QHS-d3;Artemisine-d3;Arteannuin-d3;Artemisinin-d3;Huanghuahaosu-d3;[2H3]-Artemisinin;(3R,5aS,6R,8aS,9R,12S,12aR)-Octahydro-3,6-dimethyl-9-(methyl-d3)-3,12-epox-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-one;3,12-Epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-one, octahydro-3,6-dimethyl-9-(methyl-d3)-, [3R-(3α,5aβ,6β,8aβ,9α,12β,12aR*)]- (9CI)
- CBNumber
- CB01176133
- Molecular Formula
- C15H22O5
- Formula Weight
- 282.33218
- MOL File
- 176652-07-6.mol
Artemisinin-d3 Property
- Melting point:
- 156-157°C
- storage temp.
- -20°C Freezer
- solubility
- DMSO: Slightly soluble,Methanol: Slightly soluble
- form
- A solid
- CAS DataBase Reference
- 176652-07-6
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H242Heating may cause a fire
H400Very toxic to aquatic life
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P220Keep/Store away from clothing/…/combustible materials.
P234Keep only in original container.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P391Collect spillage. Hazardous to the aquatic environment
P410Protect from sunlight.
P411+P235Store at temperatures not exceeding … oC/…oF. Keep cool.
P420Store away from other materials.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 25359
- Product name
- Artemisinin-d3
- Purity
- ≥99% deuterated forms (d1-d3)
- Packaging
- 1mg
- Price
- $485
- Updated
- 2024/03/01
- Product number
- 002878
- Product name
- Artemisinin-d3
- Packaging
- 1mg
- Price
- $566
- Updated
- 2021/12/16
- Product number
- A777502
- Product name
- Artemisinin-d3
- Packaging
- 10mg
- Price
- $2180
- Updated
- 2021/12/16
- Product number
- BAR0003036
- Product name
- ARTEMISININ-D3
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $501.36
- Updated
- 2021/12/16
- Product number
- AA0024Q4
- Product name
- 3,12-Epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-one,octahydro-3,6-dimethyl-9-(methyl-d3)-,[3R-(3α,5aβ,6β,8aβ,9α,12β,12aR*)]-(9CI)
- Purity
- ≥99%deuteratedforms(d<sub>1</sub>-d<sub>3</sub>)
- Packaging
- 5mg
- Price
- $2038
- Updated
- 2021/12/16
Artemisinin-d3 Chemical Properties,Usage,Production
Description
Artemisinin-d3 is intended for use as an internal standard for the quantification of artemisinin . Artemisinin is an endoperoxide antimalarial agent with anticancer activity. It reduces the growth of various P. falciparum strains in vitro (IC50s = 3.98-20.36 nM) and reduces parasitemia in mice infected with P. falciparum with a curative dose (CD50) value of 140 mg/kg. It also reduces P. berghei infection in mice (ED50 = 5.6 mg/kg per day). Artemisinin (100-400 μM) induces cell cycle arrest in the G0/G1 phase and apoptosis and inhibits growth of SK-N-AS, BE(2)-C, SK-N-DZ, and SHEP1 neuroblastoma cells in a time- and concentration-dependent manner. It also suppresses BE(2)-C cell colony formation in a soft agar assay and reduces tumor growth in a BE(2)-C mouse xenograft model. Formulations containing artemisinin have been used in combination therapies for the treatment of malaria.
Chemical Properties
Crystalline Solid
Uses
Active antimalarial constituent of the tradional Chinese medicinal herb Artemisia annua L., Compositae, which has been known for almost 2000 years as Qinghao. Antimalarial
IC 50
Plasmodium
References
[1] MONIQUE AKOACHERE. In vitro assessment of methylene blue on chloroquine-sensitive and -resistant Plasmodium falciparum strains reveals synergistic action with artemisinins.[J]. Antimicrobial Agents and Chemotherapy, 2005: 4592-4597. DOI: 10.1128/aac.49.11.4592-4597.2005
[2] SHUNQIN ZHU. Artemisinin reduces cell proliferation and induces apoptosis in neuroblastoma.[J]. Oncology reports, 2014, 32 3: 1094-1100. DOI: 10.3892/or.2014.3323
[3] ANNE ROBERT. The antimalarial drug artemisinin alkylates heme in infected mice.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2005, 102 38: 13676-13680. DOI: 10.1073/pnas.0500972102
[4] A.N. CHAWIRA. The effect of combinations of qinghaosu (artemisinin) with standard antimalarial drugs in the suppressive treatment of malaria in mice[J]. Transactions of The Royal Society of Tropical Medicine and Hygiene, 1987, 81 4: Pages 554-558. DOI: 10.1016/0035-9203(87)90404-4
Artemisinin-d3 Preparation Products And Raw materials
Raw materials
Preparation Products
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