Benzolamide
- Product Name
- Benzolamide
- CAS No.
- 3368-13-6
- Chemical Name
- Benzolamide
- Synonyms
- W-1803;W 1803;Benzolamide;Benzolamide, 10 mM in DMSO;2-benzenesulfonamido-1,3,4-thiadiazole-5-sulfonamide;5-(Phenylsulfonamido)-1,3,4-thiadiazole-2-sulfonamide;5-(phenylsulfonylamino)-1,3,4-thiadiazole-2-sulfonamide;1,3,4-Thiadiazole-2-sulfonamide, 5-[(phenylsulfonyl)amino]-;Benzolamide,Inhibitor,Carbonate dehydratase,seizures,CAS3,glaucoma,inhibit,Carbonic Anhydrase
- CBNumber
- CB01178102
- Molecular Formula
- C8H8N4O4S3
- Formula Weight
- 320.37
- MOL File
- 3368-13-6.mol
Benzolamide Property
- Melting point:
- 239.5°C (rough estimate)
- Boiling point:
- 585.9±33.0 °C(Predicted)
- Density
- 1.6772 (rough estimate)
- refractive index
- 1.5690 (estimate)
- storage temp.
- 4°C, protect from light
- solubility
- DMSO : 250 mg/mL (780.35 mM; Need ultrasonic)
- form
- Solid
- pka
- 4.42±0.40(Predicted)
- color
- White to light yellow
- Water Solubility
- 384.4mg/L(25 ºC)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- INB0001810
- Product name
- BENZOLAMIDE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $498.43
- Updated
- 2021/12/16
- Product number
- CD11141461
- Product name
- 5-(Phenylsulfonamido)-1,3,4-thiadiazole-2-sulfonamide
- Purity
- 97%
- Packaging
- 250mg
- Price
- $500
- Updated
- 2021/12/16
Benzolamide Chemical Properties,Usage,Production
Uses
Benzolamide (CL11366) is a potent carbonic anhydrase (CA) inhibitor, with Kis of 15 nM, 9 nM, 94 nM and 78 nM for hCA I, hCA II, EcoCAγ and VchCAγ, respectively. Benzolamide also inhibits CAS3, with a Ki of 54 nM. Benzolamide can be used for the research of glaucoma and seizures[1][2][3].
in vivo
Benzolamide (90 μmol/kg; i.p.) decreases brain pH and suppresses electrographic post-asphyxia seizures in rats[3].
| Animal Model: | Male and female Wistar Han rats (11-day-old)[3] |
| Dosage: | 90 μmol/kg |
| Administration: | A single i.p. |
| Result: | Induced a fast brain acidosis of a comparable magnitude. Suppressed electrographic seizures after asphyxia by slowing down the recovery of brain pH. |
IC 50
CA Ⅱ
References
[1] Prete SD, et, al. Escherichia coli γ-carbonic anhydrase: characterisation and effects of simple aromatic/heterocyclic sulphonamide inhibitors. J Enzyme Inhib Med Chem. 2020 Dec;35(1):1545-1554. DOI:10.1080/14756366.2020.1800670
[2] Vullo D, et, al. Sulfonamide Inhibition Studies of the β-Class Carbonic Anhydrase CAS3 from the Filamentous Ascomycete Sordaria macrospora. Molecules. 2020 Feb 25;25(5):1036. DOI:10.3390/molecules25051036
[3] Pospelov AS, et, al. Carbonic anhydrase inhibitors suppress seizures in a rat model of birth asphyxia. Epilepsia. 2021 Jun 27. DOI:10.1111/epi.16963
Benzolamide Preparation Products And Raw materials
Raw materials
Preparation Products
Benzolamide Suppliers
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
- Country
- United States
- ProdList
- 32435
- Advantage
- 58