Crisnatol
- Product Name
- Crisnatol
- CAS No.
- 96389-68-3
- Chemical Name
- Crisnatol
- Synonyms
- 770U-82;BW-A-770U;Crisnatol;Crisnatolum;Crisnatol [inn];Unii-2J71ur51ue;Crisnatolum [latin];2-((6-chrysenylmethyl)amino)-2-methyl-1,3-propanediol;2-(Chrysene-6-ylmethylamino)-2-methyl-1,3-propanediol;2-[(Chrysen-6-ylmethyl)amino]-2-methyl-1,3-propanediol
- CBNumber
- CB01178384
- Molecular Formula
- C23H23NO2
- Formula Weight
- 345.43
- MOL File
- 96389-68-3.mol
Crisnatol Property
- form
- Solid
- color
- White to off-white
N-Bromosuccinimide Price
- Product number
- API0011144
- Product name
- CRISNATOL
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $496.84
- Updated
- 2021/12/16
Crisnatol Chemical Properties,Usage,Production
Uses
Crisnatol (BWA770U) is an orally active and anticancer agent, and a member of the arylmethylaminopropanediol class of DNA intercalators. Crisnatol shows in vitro cytotoxicity against human breast cancer cells, but not normal human skin fibroblasts[1][2][3].
in vivo
Crisnatol (25 mg/kg; p.o.; single dose) shows oral activity and shows stable metabolite profile extract of rat feces by autoradiography[2].
References
[1] Adams DJ. In vitro pharmacodynamic assay for cancer drug development: application to crisnatol, a new DNA intercalator. Cancer Res. 1989 Dec 1;49(23):6615-20. PMID:1676660
[2] Patel DK, et al. Metabolism of a novel antitumor agent, crisnatol, by a human hepatoma cell line, Hep G2, and hepatic microsomes. Characterization of metabolites. Biochem Pharmacol. 1991 Jul 5;42(2):337-46. DOI:10.1016/0006-2952(91)90721-g
[3] Patel DK, et al. Disposition, metabolism, and excretion of the anticancer agent crisnatol in the rat. Drug Metab Dispos. 1991 Mar-Apr;19(2):491-7. PMID:1676660
Crisnatol Preparation Products And Raw materials
Raw materials
Preparation Products
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