HigenaMine Hydrochloride
Toxicity- Product Name
- HigenaMine Hydrochloride
- CAS No.
- 11041-94-4
- Chemical Name
- HigenaMine Hydrochloride
- Synonyms
- Demethyl;AI301335;AI3 01335;AI3-01335;norcoclaurine hcl;(+/-)-Higenamine HCl;Demethyl Trelagllptin;Higenamine hydrochloride;Higenamine hydrochloride-RM;Norcoclaurine hydrochloride
- CBNumber
- CB01178445
- Molecular Formula
- C16H18ClNO3
- Formula Weight
- 307.77
- MOL File
- 11041-94-4.mol
HigenaMine Hydrochloride Property
- storage temp.
- 4°C, protect from light
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- color
- Pale Beige to Pale Brown
- Stability:
- Hygroscopic
Safety
- Toxicity
- mouse,LD50,intravenous,17250ug/kg (17.25mg/kg),Zhongcaoyao. Chinese Traditional and Herbal Medicine. Vol. 13, Pg. 489, 1982.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H319Causes serious eye irritation
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P337+P313IF eye irritation persists: Get medical advice/attention.
P391Collect spillage. Hazardous to the aquatic environment
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- SML2313
- Product name
- Higenamine hydrochloride
- Purity
- ≥95% (HPLC)
- Packaging
- 5mg
- Price
- $86.73
- Updated
- 2025/07/31
- Product number
- SML2313
- Product name
- Higenamine hydrochloride
- Purity
- ≥95% (HPLC)
- Packaging
- 25mg
- Price
- $258.3
- Updated
- 2025/07/31
- Product number
- PHL83509
- Product name
- Higenamine hydrochloride
- Purity
- phyproof<SUP>®</SUP> Reference Substance
- Packaging
- 10 mg
- Price
- $467
- Updated
- 2025/07/31
- Product number
- H325818
- Product name
- Higenamine hydrochloride
- Packaging
- 1g
- Price
- $275
- Updated
- 2021/12/16
- Product number
- 361800
- Product name
- Higenamine Hydrochloride
- Packaging
- 20mg
- Price
- $297
- Updated
- 2021/12/16
HigenaMine Hydrochloride Chemical Properties,Usage,Production
Toxicity
The safety of orally administered higenamine hydrochloride in humans is unknown. During a study of acute toxicity, mice were orally administered the compound at a dose of 2 g per kg of bodyweight. No mice died during the study.In human trials of intravenous higenamine, subjects who received higenamine reported shortness of breath, racing heart, dizziness, headaches, chest tightness.
Description
Higenamine is a chemical found in several plants including aconite, Annona squamosa, Nandina domestica (sacred bamboo), and others. HigenaMine Hydrochloride is the hydrochloride form of higenamine.
Chemical Properties
White crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Linderae odorata.
Uses
Higenamine HCl (norcoclaurine) is a plant-based alkaloid widely used as nutritional supplement in food and beverage industries.
in vivo
Higenamine hydrochloride (10 mg/kg; Intraperitoneal injection; Single dose) can significantly reduce the inflammation and infarct size of cerebral ischemic injury caused by middle cerebral artery occlusion (MCAO) in Sprague-Dawley rats[2].
Higenamine hydrochloride (0.5-4.5 mg/kg; Single dose) improves cardiac and renal function in rats with cardio-renal syndrome (CRS) and alleviates cardiac and renal fibrosis by targeting ASK1/MAPK (ERK, P38)/NF-kB signaling pathway in Sprague-Dawley rats[4].
Higenamine hydrochloride (20 mg/kg-30 mg/kg; Intraperitoneal injection; Once daily for 60 days) promotes bone formation and prevents accelerated bone loss in SAMP6 mice[6].
| Animal Model: | Spontaneous osteoporosis SAMP6 mice model[6] |
| Dosage: | 10 mg/kg, 20 mg/kg |
| Administration: | Intraperitoneal injection (i.p.);Once daily for 60 days |
| Result: | Significantly increased the expression of P1NP and OCN (P1NP and OCN are markers of bone formation). |
IC 50
β adrenergic receptor; ASK1
HigenaMine Hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
HigenaMine Hydrochloride Suppliers
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View Lastest Price from HigenaMine Hydrochloride manufacturers
- Product
- HigenaMine Hydrochloride 11041-94-4
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1000kg
- Release date
- 2025-07-08
- Product
- HigenaMine Hydrochloride 11041-94-4
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-29
- Product
- Demethyl 11041-94-4
- Price
- US $310.00/Kg/Bag
- Min. Order
- 1KG
- Purity
- 99
- Supply Ability
- 1T
- Release date
- 2021-06-04