Lintopride
- Product Name
- Lintopride
- CAS No.
- 107429-63-0
- Chemical Name
- Lintopride
- Synonyms
- Lintopride;Benzamide, 4-amino-5-chloro-N-[(1-ethyl-4,5-dihydro-1H-imidazol-2-yl)methyl]-2-methoxy-
- CBNumber
- CB01179048
- Molecular Formula
- C14H19ClN4O2
- Formula Weight
- 310.78
- MOL File
- 107429-63-0.mol
Lintopride Property
- Boiling point:
- 494.1±45.0 °C(Predicted)
- Density
- 1.35±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- Solid
- pka
- 13.20±0.46(Predicted)
- color
- Light yellow to yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- API0011792
- Product name
- LINTOPRIDE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $502.48
- Updated
- 2021/12/16
- Product number
- CS-7158
- Product name
- Lintopride
- Purity
- 96.38%
- Packaging
- 10mg
- Price
- $816
- Updated
- 2021/12/16
- Product number
- CSN21712
- Product name
- Lintopride
- Packaging
- 1mg
- Price
- $204
- Updated
- 2021/12/16
- Product number
- CSN21712
- Product name
- Lintopride
- Packaging
- 5mg
- Price
- $408
- Updated
- 2021/12/16
Lintopride Chemical Properties,Usage,Production
Uses
Lintopride, a benzamide, is a potent 5HT-4 antagonist with moderate 5HT-3 antagonist properties. Lintopride increases gastric emptying, stimulates antral and duodenal motility and accelerates intestinal transit in animal. Lintopride significantly increases the lower oesophageal sphincter (LOS) basal tone[1].
Biological Activity
Lintopride is a 5HT4 antagonist with a slight antagonistic effect on 5HT3.
in vitro
Lintopride significantly increases the lower oesophageal sphincter basal tone without affecting lower oesophageal sphincter physiological relaxation after swallowing. Peristaltic waves are also enhanced by Lintopride.
target
| 5-HT 4 Receptor
| 5-HT 3 Receptor
|
IC 50
5-HT4 Receptor; 5-HT3 Receptor
References
[1] Delvaux M, et al. The effects of lintopride, a 5HT-4 antagonist, on oesophageal motility. Aliment Pharmacol Ther. 1995 Oct;9(5):563-9. DOI:10.1111/j.1365-2036.1995.tb00422.x
Lintopride Preparation Products And Raw materials
Raw materials
Preparation Products
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