METHOXYACETIC ACID HYDRAZIDE
- Product Name
- METHOXYACETIC ACID HYDRAZIDE
- CAS No.
- 20605-41-8
- Chemical Name
- METHOXYACETIC ACID HYDRAZIDE
- Synonyms
- AKOS B015437;ART-CHEM-BB B015437;METHOXYACETOHYDRAZIDE;2-METHOXYACETOHYDRAZIDE;2-methoxyethanehydrazide;METHOXYACETIC ACID HYDRAZIDE;Acetic acid, 2-methoxy-, hydrazide
- CBNumber
- CB0119676
- Molecular Formula
- C3H8N2O2
- Formula Weight
- 104.11
- MOL File
- 20605-41-8.mol
METHOXYACETIC ACID HYDRAZIDE Property
- Melting point:
- 58-59°C
- Boiling point:
- 271.5±23.0 °C(Predicted)
- Density
- 1.107±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- form
- Solid
- pka
- 12.29±0.18(Predicted)
- Appearance
- White to off-white Solid
- CAS DataBase Reference
- 20605-41-8(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 20/21/22-36/37/38
- Safety Statements
- 26-36/37/39
- HazardClass
- IRRITANT
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- M261153
- Product name
- 2-Methoxyacetohydrazide
- Packaging
- 500mg
- Price
- $40
- Updated
- 2021/12/16
- Product number
- M261153
- Product name
- 2-Methoxyacetohydrazide
- Packaging
- 1g
- Price
- $50
- Updated
- 2021/12/16
- Product number
- CS-W005634
- Product name
- 2-Methoxyacetohydrazide
- Purity
- 98.92%
- Packaging
- 100g
- Price
- $95
- Updated
- 2021/12/16
- Product number
- AK110451
- Product name
- 2-Methoxyacetohydrazide
- Purity
- 95+%
- Packaging
- 10g
- Price
- $14
- Updated
- 2021/12/16
- Product number
- 029897
- Product name
- 2-Methoxyacetohydrazide
- Packaging
- 5g
- Price
- $29
- Updated
- 2021/12/16
METHOXYACETIC ACID HYDRAZIDE Chemical Properties,Usage,Production
Uses
2-Methoxyacetohydrazide is used in preparation of Benzylaminopyrazolopyrimidinone derivatives and analogs for use as DNA polymerase IIIC inhibitors.
Synthesis
6290-49-9
20605-41-8
Preparative Example 5: Synthesis of 2-methoxyacetohydrazide Hydrazine monohydrate (9.85 mL, 202 mmol) was slowly added to a solution of methyl methoxyacetate (10 mL, 101 mmol) in methanol (50 mL). The reaction mixture was continuously stirred and heated at 70 °C for 18 hours. Upon completion of the reaction, the mixture was cooled to room temperature and subsequently concentrated under reduced pressure in a rotary evaporator to remove the solvent. Toluene (2 x 50 mL) was added to the residue for azeotropic dehydration to give a white solid product. The solid was ground with ether (50 mL) for further purification, followed by vacuum drying at 50 °C for 30 min to give the final methoxyacetylhydrazine as a white solid in 95% yield (9.98 g). The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 3.26 (s, 3H), 3.79 (s, 2H), 4.22 (bs, 2H), 8.97 (bs, 1H).
References
[1] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 2, p. 516 - 520
[2] Patent: US2006/160786, 2006, A1. Location in patent: Page/Page column 22
[3] Patent: WO2005/74904, 2005, A2. Location in patent: Page/Page column 57-58
[4] Patent: WO2004/108661, 2004, A1. Location in patent: Page/Page column 51
[5] Patent: WO2005/63742, 2005, A2. Location in patent: Page/Page column 23
METHOXYACETIC ACID HYDRAZIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from METHOXYACETIC ACID HYDRAZIDE manufacturers
- Product
- METHOXYACETIC ACID HYDRAZIDE 20605-41-8
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-10
- Product
- METHOXYACETIC ACID HYDRAZIDE 20605-41-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2019-07-03