(-)-ANABASINE

Product Name: (-)-ANABASINE
CAS No.: 494-52-0
Chemical Name: (-)-ANABASINE
Synonyms: Anabasin;Anabazin;ANOBASINE;ANABASINE;Neonikoti;Neonikotin;NEONICOTINE;L-ANABASINE;(-)-anabasin;(-)-ANABASINE
CBNumber: CB0119964
Molecular Formula: C10H14N2
Formula Weight: 162.23
MOL File: 494-52-0.mol

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(-)-ANABASINE Property

Melting point:: 9°C
Boiling point:: 270-272°C
alpha: D20 -83.1°
Density: 1,0455 g/cm³
refractive index: 1.5430
Flash point:: 93°C
storage temp.: 2-8°C
solubility: DMSO : 100 mg/mL (616.41 mM)
pka: 8.98±0.10(Predicted)
form: Liquid
Merck: 14,619
BRN: 82637
CAS DataBase Reference: 494-52-0(CAS DataBase Reference)
NIST Chemistry Reference: Pyridine, 3-(2-piperidinyl)-, (S)-(494-52-0)
EPA Substance Registry System: Anabasine (494-52-0)

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Safety

Hazard Codes: T
Risk Statements: 27/28-51/53-23/24/25
Safety Statements: 28-36/37-45-61-36/37/39-28A
RIDADR: 3140
RTECS: BV4375000
HazardClass: 6.1
PackingGroup: I
HS Code: 29333990
Hazardous Substances Data: 494-52-0(Hazardous Substances Data)
Toxicity: LDLo orl-dog: 50 mg/kg JPETAB 48,95,33

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H300Fatal if swallowed

H310Fatal in contact with skin

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P262Do not get in eyes, on skin, or on clothing.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P302+P350IF ON SKIN: Gently wash with plenty of soap and water.

P310Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P322Specific measures (see …on this label).

P330Rinse mouth.

P361Remove/Take off immediately all contaminated clothing.

P363Wash contaminated clothing before reuse.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: A637170
Product name: (S)-Anabasine,>98%ee
Packaging: 100mg
Price: $350
Updated: 2021/12/16

TRC

Product number: A637170
Product name: (S)-Anabasine,>98%ee
Packaging: 500mg
Price: $1455
Updated: 2021/12/16

ChemScene

Product number: CS-0013343
Product name: Anabasine
Purity: 98.71%
Packaging: 10mg
Price: $60
Updated: 2021/12/16

ChemScene

Product number: CS-0013343
Product name: Anabasine
Purity: 98.71%
Packaging: 25mg
Price: $90
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA17898
Product name: (S)-Anabasine
Packaging: 50mg
Price: $110
Updated: 2021/12/16

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(-)-ANABASINE Chemical Properties,Usage,Production

Chemical Properties

Pale Yellow Oil

Uses

Anabasine occurs in the tobacco speciesNicotiana glauca, Anabasis aphylla L.,Chenopodiaceae, and Solanaceae. It is usedas an insecticide and as a metal anticorrosiveagent.

Uses

(S)-ANABASINE is used as a kind of Nicotinic receptor agonist.

Definition

ChEBI: The (S)-enantiomer of anabasine.

Health Hazard

The acute toxic symptoms include increasedsalivation, confusion, disturbed vision, photophobia,nausea, vomiting, diarrhea, respiratorydistress, and convulsions. It causesrespiratory muscle stimulation similar to thatcaused by lobeline. An oral lethal dose indogs is 50 mg/kg. A subcutaneous lethaldose in guinea pigs is 10 mg/kg.

Biological Activity

Anabasine ((S)-Anabasine) is an alkaloid, a component of tobacco. Anabasine is a botanical insecticide that acts as a pan-agonist of nicotinic acetylcholine receptors (nAChRs). Anabasine induces depolarization in TE671 cells endogenously expressing human myogenic nAChRs (EC50=0.7 μM).

Safety Profile

Poison by ingestion,subcutaneous, and intravenous routes. Moderately toxicby skin contact. An experimental teratogen. Insecticide.Acute and subacute toxicity: increased salivation, vertigo,confusion, disturbed vision and hearing, photophobia,cold ext

in vivo

Anabasine significantly reverses the impairment at the 0.2 mg/kg (p<0.05) and 2 mg/kg doses (p<0.025). Anabasine does not have any significant effects on response latency when administered alone. The 0.06 mg/kg Anabasine dose, in fact, significantly (p<0.05) exacerbates the dizocilpine-induced impairment. None of these Anabasine doses affects choice accuracy on their own. Individual dose comparisons show that the 0.06 mg/kg Anabasine dose plus dizocilpine (6.7±2.6) causes a significant (p<0.05) increase in non-response trials compare with dizocilpine alone (2.1±0.8).

(-)-ANABASINE Preparation Products And Raw materials

Raw materials

Preparation Products

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(-)-ANABASINE Suppliers

Belgium 1 Canada 1 China 87 Europe 1 Germany 3 India 4 Japan 1 Russia 1 Ukraine 2 United Kingdom 5 United States 21 Global 127

Jiangsu yize medical technology co. LTD

Tel: 18550739526
Email: 3394205705@qq.com
Country: China
ProdList: 9389
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15848
Advantage: 69

Chembest Research Laboratories Limited

Tel: 021-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6011
Advantage: 61

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30132
Advantage: 84

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44751
Advantage: 61

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32344
Advantage: 50

Maya High Purity Chemicals

Tel: +86 (573) 82222445 (0)18006601000 452520369
Fax: +86 (573) 82222643
Email: sales@maya-r.com
Country: China
ProdList: 11714
Advantage: 57

S.Z. PhyStandard Bio-Tech. Co., Ltd.

Tel: 0755-83725681-603
Fax: +86 755 28094224
Country: China
ProdList: 4505
Advantage: 50

Beijing innoChem Science & Technology Co.,Ltd.

Tel: 400-810-7969 010-59572699
Fax: 010-59572688
Email: ningzi.li@inno-chem.com.cn
Country: China
ProdList: 6139
Advantage: 55

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View Lastest Price from (-)-ANABASINE manufacturers

Anhui Rencheng Technology Co., Ltd

Product: Anabasine 494-52-0
Price: US $1.00-90.00/KG
Min. Order: 0.5KG
Purity: >99%
Supply Ability: 20tons
Release date: 2021-07-28

Zhuozhou Wenxi import and Export Co., Ltd

Product: (-)-ANABASINE 494-52-0
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-10

Career Henan Chemical Co

Product: Anabasine 494-52-0
Price: US $8.00/KG
Min. Order: 1g
Purity: ≥98%
Supply Ability: kg--tons
Release date: 2020-03-05

494-52-0, (-)-ANABASINERelated Search:

Protionamide Sulfoxide (-)-ANABASINE AKOS 213-73 (S)-3-(3,4,5,6-TETRAHYDRO-2H-[2,3']BIPYRIDINYL-1-YL)-PROPIONIC ACID METHYL ESTER (R,S)-N-NITROSOANABASINE 4-OXO-4-(S)-3,4,5,6-TETRAHYDRO-2H-[2,3']BIPYRIDINYL-1-YL-BUTYRIC ACID (+/-)-ANABASINE DIPICRATE (-)-ANABASINE N-Methylanabasine 4-METHOXY-3-[(S)-1-(3,4,5,6-TETRAHYDRO-2H-[2,3']BIPYRIDINYL-1-YL)METHYL]-BENZALDEHYDE (S)-2-(3,4,5,6-TETRAHYDRO-2H-[2,3']BIPYRIDINYL-1-YL)-ETHANOL (+)-Anabasinehydrochloride AKOS 213-74 3-[(2S)-PIPERIDIN-2-YL]PYRIDINE HYDROCHLORIDE ANABASINE SULFATE

(-)-anabasin

(s)-3-(2-piperidinyl)pyridine

ANOBASINE

L(-)-Anabasine,90%

(2S)-3-(2-Piperidinyl)-pyridine

(-)-2-(3'-Pyridyl)piperidine

L(-)-Anabasine, 90% 500MG

(S)-(-)-2-(3-PYRIDYL)PIPERIDINE

(S)-1,2,3,4,5,6-HEXAHYDRO-[2,3']BIPYRIDINYL

NEONICOTINE

L(-)-NEONICOTINE

L(-)-ANABASINE

L-ANABASINE

2-(3-PYRIDYL)PIPERIDINE

(-)-ANABASINE

ANABASINE

Nicotine USP RC G

3-(2S)-2-Piperidinyl-pyridine

Neonikoti

2-(3-pyridyl)-piperidin

3-(2-Piperidinyl)pyridine

3-(2-piperidyl)-pyridin

Anabasin

Anabazin

l-3-(2’-piperidyl)pyridine

L-3-(2'-Piperidyl)pyridine

Neonikotin

Piperidine, 2-(3-pyridyl)-

Pyridine, 3-(2-piperidyl)-

pyridine,3-(2-pyridyl)piperidine

S-(-)-Anabasine

(S)-3-(Piperidin-2-yl)pyridine+

PYRIDINE,3-(2S)-2-PIPERIDINYL-,

3-((S)-piperidin-2-yl)pyridine

Nicotine Related Compound G (20 mg)

(S)-Anabasine, > 70% ee DISCONTINUED. Please see A637170

(S)-Anabasine, > 98% ee

Nicotine Impurity G

Nicotine USP Related Compound G

3-[(2S)-piperidin-2-yl]pyridine (anabasine)

(S)-Snabasine

Rizatriptan Impurity 3-d6 Benzoate Salt（Rizatriptan EP Impurity C-d6 Benzoate Salt）

494-52-0

Aromatics Compounds

Aromatics

Chiral Reagents

Nicotine Derivatives