ChemicalBook > CAS DataBase List > BI-0474

BI-0474

Product Name
BI-0474
CAS No.
2750570-55-7
Chemical Name
BI-0474
Synonyms
BI-0474;Benzo[b]thiophene-3-carbonitrile, 2-amino-4-[3-[6-[(2S)-2,4-dimethyl-1-piperazinyl]-4-[4-(1-oxo-2-propen-1-yl)-1-piperazinyl]-2-pyridinyl]-1,2,4-oxadiazol-5-yl]-4,5,6,7-tetrahydro-4-methyl-, (4S)-
CBNumber
CB012245556
Molecular Formula
C30H37N9O2S
Formula Weight
587.74
MOL File
2750570-55-7.mol
More
Less

BI-0474 Property

Boiling point:
879.4±75.0 °C(Predicted)
Density 
1.38±0.1 g/cm3(Predicted)
pka
7.13±0.70(Predicted)
form 
Solid
color 
White to off-white
InChIKey
CKAMBYUZKWQCKJ-ADSBAMQRSA-N
SMILES
C12CCC[C@@](C3ON=C(C4=NC(N5CCN(C)C[C@@H]5C)=CC(N5CCN(C(=O)C=C)CC5)=C4)N=3)(C)C=1C(C#N)=C(N)S2
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

BI-0474 Chemical Properties,Usage,Production

Description

BI-0474 is a potent KRASG12C inhibitor with an IC50 value of 7.0 nM.

Uses

BI-0474 is a potent KRASG12C inhibitor with an IC50 value of 7.0 nM for the GDP-KRAS::SOS1 protein-protein interaction. It exhibits good anti-proliferative activity against NCI-H358 cells carrying the G12C mutation. BI-0474 also shows good anti-tumour activity in non-small cell lung cancer xenograft models.

in vitro

BI-0474 (1-10,000 nM; 3 days) shows potent antiproliferative activity of 26 nM on NCI-H358 cells carrying a G12C mutation.

in vivo

BI-0474 (40 mg/kg; i.p.; single daily for 3 days) shows anti-tumor efficacy and pharmacodynamic biomarker modulation in an NCI-H358 cell line-derived non-small cell lung cancer xenograft model

BI-0474 Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

BI-0474 Suppliers

China 29 United States 1 Global 30
Hubei Chuchang Chemical Co., Ltd
Tel
18; 15623560702
Email
Joy.Ren@aliyun.com
Country
China
ProdList
160
Advantage
58
Changzhou Borl Biotechnology Co.,LTD
Tel
13606124132;13656121842
Email
luyan0021@163.com
Country
China
ProdList
218
Advantage
58
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185 18149758185
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
3466
Advantage
58
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4569
Advantage
55
ShangHai Angti Biotechnology Co., Ltd.
Tel
13764913901
Fax
-
Email
info@angtibio.com
Country
China
ProdList
5028
Advantage
55
ShangHai Biochempartner Co.,Ltd
Tel
17754423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8011
Advantage
62
Shanghai Rechem science Co., Ltd.
Tel
21-31433387 15618786686
Fax
QQ:1369748377
Email
sales@rechemscience.com
Country
China
ProdList
2951
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32161
Advantage
58
DC Chemicals
Tel
021-58447131 13564518121
Email
sales@dcchemicals.com
Country
China
ProdList
9409
Advantage
58
Changzhou Chenhong Biotechnology Co., Ltd.
Tel
0519-85788828 13775037613
Email
sales@chemrenpharm.com
Country
China
ProdList
3600
Advantage
58
More
Less

View Lastest Price from BI-0474 manufacturers

Hubei Chuchang Biotech Co., Ltd.
Product
BI-0474 2750570-55-7
Price
US $0.00-0.00/mg
Min. Order
5mg
Purity
98%+ HPLC HNMR
Supply Ability
10g
Release date
2024-04-17

2750570-55-7, BI-0474Related Search:


  • Benzo[b]thiophene-3-carbonitrile, 2-amino-4-[3-[6-[(2S)-2,4-dimethyl-1-piperazinyl]-4-[4-(1-oxo-2-propen-1-yl)-1-piperazinyl]-2-pyridinyl]-1,2,4-oxadiazol-5-yl]-4,5,6,7-tetrahydro-4-methyl-, (4S)-
  • BI-0474
  • 2750570-55-7
  • C30H37N9O2S