ChemicalBook > CAS DataBase List > BI-0474
BI-0474
- Product Name
- BI-0474
- CAS No.
- 2750570-55-7
- Chemical Name
- BI-0474
- Synonyms
- BI-0474;Benzo[b]thiophene-3-carbonitrile, 2-amino-4-[3-[6-[(2S)-2,4-dimethyl-1-piperazinyl]-4-[4-(1-oxo-2-propen-1-yl)-1-piperazinyl]-2-pyridinyl]-1,2,4-oxadiazol-5-yl]-4,5,6,7-tetrahydro-4-methyl-, (4S)-
- CBNumber
- CB012245556
- Molecular Formula
- C30H37N9O2S
- Formula Weight
- 587.74
- MOL File
- 2750570-55-7.mol
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BI-0474 Property
- Boiling point:
- 879.4±75.0 °C(Predicted)
- Density
- 1.38±0.1 g/cm3(Predicted)
- pka
- 7.13±0.70(Predicted)
- form
- Solid
- color
- White to off-white
- InChIKey
- CKAMBYUZKWQCKJ-ADSBAMQRSA-N
- SMILES
- C12CCC[C@@](C3ON=C(C4=NC(N5CCN(C)C[C@@H]5C)=CC(N5CCN(C(=O)C=C)CC5)=C4)N=3)(C)C=1C(C#N)=C(N)S2
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BI-0474 Chemical Properties,Usage,Production
Description
BI-0474 is a potent KRASG12C inhibitor with an IC50 value of 7.0 nM.
Uses
BI-0474 is a potent KRASG12C inhibitor with an IC50 value of 7.0 nM for the GDP-KRAS::SOS1 protein-protein interaction. It exhibits good anti-proliferative activity against NCI-H358 cells carrying the G12C mutation. BI-0474 also shows good anti-tumour activity in non-small cell lung cancer xenograft models.
in vitro
BI-0474 (1-10,000 nM; 3 days) shows potent antiproliferative activity of 26 nM on NCI-H358 cells carrying a G12C mutation.
in vivo
BI-0474 (40 mg/kg; i.p.; single daily for 3 days) shows anti-tumor efficacy and pharmacodynamic biomarker modulation in an NCI-H358 cell line-derived non-small cell lung cancer xenograft model
BI-0474 Preparation Products And Raw materials
Raw materials
Preparation Products
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BI-0474 Suppliers
- Tel
- +1-781-999-5354 +1-00000000000
- marketing@targetmol.com
- Country
- United States
- ProdList
- 32161
- Advantage
- 58
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View Lastest Price from BI-0474 manufacturers
Hubei Chuchang Biotech Co., Ltd.
- Product
- BI-0474 2750570-55-7
- Price
- US $0.00-0.00/mg
- Min. Order
- 5mg
- Purity
- 98%+ HPLC HNMR
- Supply Ability
- 10g
- Release date
- 2024-04-17