6H-Benzo(d)naphtho(1,2-b)pyran-6-one, 4-(6-deoxy-alpha-galactofuranosy l)-1-hydroxy-10,12-dimethoxy-8-methyl-
- Product Name
- 6H-Benzo(d)naphtho(1,2-b)pyran-6-one, 4-(6-deoxy-alpha-galactofuranosy l)-1-hydroxy-10,12-dimethoxy-8-methyl-
- CAS No.
- 77879-89-1
- Chemical Name
- 6H-Benzo(d)naphtho(1,2-b)pyran-6-one, 4-(6-deoxy-alpha-galactofuranosy l)-1-hydroxy-10,12-dimethoxy-8-methyl-
- Synonyms
- gilvocarcin M;AnandiMycin B, ToroMycin B, 1072A;4-(6-Deoxy-α-L-galactofuranosyl)-1-hydroxy-10,12-dimethoxy-8-methyl-6H-benzo[d]naphtho[1,2-b]pyran-6-one;6H-Benzo[d]naphtho[1,2-b]pyran-6-one, 4-(6-deoxy-α-D-galactofuranosyl)-1-hydroxy-10,12-dimethoxy-8-methyl-;6H-Benzo(d)naphtho(1,2-b)pyran-6-one, 4-(6-deoxy-alpha-galactofuranosy l)-1-hydroxy-10,12-dimethoxy-8-methyl-
- CBNumber
- CB01243950
- Molecular Formula
- C26H26O9
- Formula Weight
- 482.48
- MOL File
- 77879-89-1.mol
6H-Benzo(d)naphtho(1,2-b)pyran-6-one, 4-(6-deoxy-alpha-galactofuranosy l)-1-hydroxy-10,12-dimethoxy-8-methyl- Property
- storage temp.
- Store at -20°C
- solubility
- DMF: soluble; DMSO: soluble
- form
- Yellow solid.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 25762
- Product name
- Gilvocarcin M
- Purity
- ≥95%
- Packaging
- 500μg
- Price
- $336
- Updated
- 2024/03/01
- Product number
- 25762
- Product name
- Gilvocarcin M
- Purity
- ≥95%
- Packaging
- 2.5mg
- Price
- $1092
- Updated
- 2024/03/01
- Product number
- G377713
- Product name
- GilvocarcinM
- Packaging
- 500μg
- Price
- $295
- Updated
- 2021/12/16
- Product number
- G2034-45
- Product name
- Gilvocarcin M
- Packaging
- 500ug
- Price
- $523
- Updated
- 2021/12/16
- Product number
- MTB0002147
- Product name
- GILVOCARCIN M
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $495.11
- Updated
- 2021/12/16
6H-Benzo(d)naphtho(1,2-b)pyran-6-one, 4-(6-deoxy-alpha-galactofuranosy l)-1-hydroxy-10,12-dimethoxy-8-methyl- Chemical Properties,Usage,Production
Description
Gilvocarcin M is an antibiotic originally isolated from S. gilvotanareus. It is active against S. aureus when used at a concentration of 32 μg/ml. Gilvocarcin M inhibits growth of KB cells (IC50 = 0.52 μg/ml) but has no effect on survival in a P388 mouse model of leukemia when used at doses ranging from 25 to 400 mg/kg. Gilvocarcin M intercalates into bacteriophage PM2 DNA. It is toxic to rats with an intravenous LD50 value of 450 mg/kg.
Uses
Gilvocarcin M is the minor analogue of a complex of C-glycoside antitumour actives isolated from a Streptomyces sp.. Gilvocarcin M contains a methyl group in the 8-position, and is less active than the vinyl analogue (gilvocarcin V), which is thought to act as an inhibitor of human topoisomerase II. Gilvocarcin M displays potent antibacterial, antifungal, antiviral and antitumour activity. Recent research suggests that the gilvocarcins act as photoactivated crosslinkers of DNA to histones.
Uses
Gilvocarcin M is the minor analogue of a complex of C-glycoside antitumor actives isolated from a Streptomyces sp.. Gilvocarcin M contains a methyl group in the 8-position, and is less active than the vinyl analogue (gilvocarcin V), which is thought to act as an inhibitor of human topoisomerase II. Gilvocarcin M displays potent antibacterial, antifungal, antiviral and antitumor activity. Recent research suggests that the gilvocarcins act as photoactivated cross-linkers of DNA to histones.
Uses
Gilvocarcin M is the minor analogue of Gilvocarcin V with anti-bact, -fungal, -viral and -tumor activity.
6H-Benzo(d)naphtho(1,2-b)pyran-6-one, 4-(6-deoxy-alpha-galactofuranosy l)-1-hydroxy-10,12-dimethoxy-8-methyl- Preparation Products And Raw materials
Raw materials
Preparation Products
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