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Clevidipine butyrate

Product Name
Clevidipine butyrate
CAS No.
167221-71-8
Chemical Name
Clevidipine butyrate
Synonyms
Cleviprex;CS-136;Clevelox;H 324/38;evidipine;rac-Clevidipine;4-b-D-Xylopentaose;Clevidipine butyrate;Cloweidipine butyrate;CLEVELOX; CLEVIDIPINE
CBNumber
CB01248667
Molecular Formula
C21H23Cl2NO6
Formula Weight
456.32
MOL File
167221-71-8.mol
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Clevidipine butyrate Property

Melting point:
128-130°C
Boiling point:
539.7±50.0 °C(Predicted)
Density 
1.289
Flash point:
280℃
storage temp. 
Keep in dark place,Inert atmosphere,2-8°C
Water Solubility 
Insoluble in water
solubility 
≥21.4 mg/mL in DMSO; insoluble in H2O; ≥7.45 mg/mL in EtOH with ultrasonic
form 
powder to crystal
pka
2.45±0.70(Predicted)
color 
White to Light yellow
CAS DataBase Reference
167221-71-8
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Safety

Safety Statements 
24/25
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H361Suspected of damaging fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P281Use personal protective equipment as required.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical
Product number
C3503
Product name
Clevidipine
Purity
>98.0%(HPLC)
Packaging
250mg
Price
$69
Updated
2024/03/01
TCI Chemical
Product number
C3503
Product name
Clevidipine
Purity
>98.0%(HPLC)
Packaging
1g
Price
$190
Updated
2024/03/01
Cayman Chemical
Product number
23025
Product name
Clevidipine Butyrate
Purity
≥98%
Packaging
10mg
Price
$81
Updated
2024/03/01
Cayman Chemical
Product number
23025
Product name
Clevidipine Butyrate
Purity
≥98%
Packaging
25mg
Price
$140
Updated
2024/03/01
Cayman Chemical
Product number
23025
Product name
Clevidipine Butyrate
Purity
≥98%
Packaging
50mg
Price
$258
Updated
2024/03/01
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Clevidipine butyrate Chemical Properties,Usage,Production

Description

Clevidipine is an ultra-short-acting vasodilator of the dihydropyridine (DHP) class of CCB. It is indicated as an intravenous treatment for the acute management of hypertension when oral therapy is not feasible or not desirable. Clevidipine is the second intravenous CCB to be marketed behind nicardipine for this indication. Both agents are primarily used for urgent treatment of hypertension in cardiac surgical setting, intensive care units, and emergency departments. Other intravenous agents currently on the market for this indication include sodium nitroprusside, nitroglycerin, fenoldopam, hydralazine, esmolol, and labetalol. Clevidipine is a potent, arterial-specific, vasodilator with very little or no effect on the myocardial contractility and venous capacitance. It has a rapid onset and offset of action and a very short plasma half-life, which allows for titration of the drug to achieve precise BP control.
clevidipine is exclusively metabolized in the blood and the tissues. It does not undergo any renal or hepatic metabolism and does not accumulate in the body. Clevidipine is a blocker of L-type calcium channels, which mediate the influx of calcium during depolarization in arterial smooth muscle.

Chemical Properties

White to Off-White Solid

Originator

AstraZeneca (United Kingdom)

Uses

Clevidipine butyrate is a dihydropyridine calcium channel blocker use as agent for the reduction of blood pressure。

Uses

Calcium channel blocker, used as an oral antihypertensive.

Uses

Clevidipine butyrate is a novel intravenous, short-acting calcium channel blocker that provides quick and accurate control of blood pressure in an emergency setting. Unlike other intravenous hypertension drugs which are metabolized in kidney or liver and tend to accumulate in the body, clevidipine is metabolized in the blood and tissues and thus avoids accumulation. The drug was launched by Medicines Company which aquired the rights from AstraZeneca.

Uses

A calcium channel protein inhibitor and blocker

Definition

ChEBI: Clevidipine is a dihydropyridine.

brand name

Clevelox (The Medicines Company).

Side effects

Clevidipine is contraindicated in patients with severe aortic stenosis, defective lipid metabolism, and allergies to eggs, egg products, soybeans, or soy products. The chemical synthesis of clevidipine entails the esterification of 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid monomethyl ester with chloromethyl butyrate by the action of potassium bicarbonate in refluxing acetonitrile.

Synthesis

The chemical synthesis of clevidipine entails the esterification of 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid monomethyl ester with chloromethyl butyrate by the action of potassium bicarbonate in refluxing acetonitrile. The DHP-monoester starting material is obtained in two steps through condensation of methyl 2,3-dichlorobenzylidine acetoacetate and 2-cyanoethyl ester of 2-amino-2-propenoic acid to the DHP diester, followed by base catalyzed cleavage of the cyanoethyl group. Clevidipine is practically insoluble in water and is formulated in an oil-inwater emulsion.

Clevidipine butyrate Preparation Products And Raw materials

Raw materials

Preparation Products

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Clevidipine butyrate Suppliers

S.Z. PhyStandard Bio-Tech. Co., Ltd.
Tel
4000505016; 13380397412
Fax
0755 28094224
Email
3001272453@qq.com
Country
China
ProdList
5000
Advantage
50
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2923
Advantage
55
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
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Chembest Research Laboratories Limited
Tel
021-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6013
Advantage
61
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24539
Advantage
81
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
zhangsn@titansci.com
Country
China
ProdList
14113
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Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32344
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50
XiaoGan ShenYuan ChemPharm co,ltd
Tel
0712-0712-2580635 15527768850
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1791901229@qq.com
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China
ProdList
8850
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Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400 638 7771
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sales@heowns.com
Country
China
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Tongchuang Pharma(Suzhou). Co., Ltd.
Tel
0512-63263366 18912765016
Fax
0512-6326 3366
Email
tongtf110@sina.com
Country
China
ProdList
1000
Advantage
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View Lastest Price from Clevidipine butyrate manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Clevidipine butyrate 167221-71-8
Price
US $0.00/Kg/Bag
Min. Order
1g
Purity
99%min
Supply Ability
10kgs
Release date
2021-07-16
Henan Bao Enluo International TradeCo.,LTD
Product
Clevidipine butyrate 167221-71-8
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000tons
Release date
2023-07-24
XuZhou Magic Biotechnology Co., Ltd.
Product
Clevidipine butyrate 167221-71-8
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20tons
Release date
2023-04-25

167221-71-8, Clevidipine butyrateRelated Search:


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