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Urapidil hydrochloride

Product Name
Urapidil hydrochloride
CAS No.
64887-14-5
Chemical Name
Urapidil hydrochloride
Synonyms
URAPIDIL HCL;Urapidil hydrochoride;URAPIDIL HYDROCHLORIDE;Eposin Etopophos Vepesid VP16;Urapidil hydrochloride USP/EP/BP;Urapidil HCl,Urapidil Hydrochloride;3-methyl-3-hydroxymethyloxyheterocyclobutane;URAPIDIL HYDROCHLORIDE A1 ADRENOCEPTOR A NTAG;6[[3-[4-(O-METHOXYPHENYL)-1-PIPERAZINYL]PROPYL]AMINO]-1,3-DIMETHYLURACIL HYDROCHLORIDE;6-[[3-[4-(2-Methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyluracil hydrochloride
CBNumber
CB6332466
Molecular Formula
C20H30ClN5O3
Formula Weight
423.94
MOL File
64887-14-5.mol
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Urapidil hydrochloride Property

Melting point:
156-1580C
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
H2O: soluble
form 
solid
color 
white
Water Solubility 
Soluble to 50 mM in water
InChI
InChI=1S/C20H29N5O3.ClH/c1-22-18(15-19(26)23(2)20(22)27)21-9-6-10-24-11-13-25(14-12-24)16-7-4-5-8-17(16)28-3;/h4-5,7-8,15,21H,6,9-14H2,1-3H3;1H
InChIKey
KTMLZVUAXJERAT-UHFFFAOYSA-N
SMILES
O(C1C=CC=CC=1N1CCN(CCCNC2=CC(=O)N(C)C(=O)N2C)CC1)C.Cl
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Safety

Hazard Codes 
Xn
Risk Statements 
22-36/37/38
Safety Statements 
26-36
WGK Germany 
3
RTECS 
YQ9862000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
U100
Product name
Urapidil hydrochloride
Purity
solid
Packaging
100mg
Price
$173
Updated
2023/06/20
Sigma-Aldrich
Product number
U100
Product name
Urapidil hydrochloride
Purity
solid
Packaging
500mg
Price
$691
Updated
2023/06/20
Alfa Aesar
Product number
J63219
Product name
Urapidil hydrochloride, 98+%
Packaging
1g
Price
$191
Updated
2023/06/20
Alfa Aesar
Product number
J63219
Product name
Urapidil hydrochloride, 98+%
Packaging
5g
Price
$605
Updated
2021/12/16
Cayman Chemical
Product number
29004
Product name
Urapidil (hydrochloride)
Packaging
250mg
Price
$73
Updated
2024/03/01
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Urapidil hydrochloride Chemical Properties,Usage,Production

Description

Urapidil is an antagonist of α1-adrenergic receptors (α1-ARs) and a partial agonist of the serotonin (5-HT) receptor subtype 5-HT1A. It selectively binds to α1- over α2-ARs (IC50s = 0.74 and 42 μM, respectively) and to 5-HT1A over 5-HT1B and 5-HT2 receptors (IC50s = 0.4, 20.4, and >10 μM, respectively) in rat cortex. Urapidil inhibits cAMP accumulation induced by forskolin in calf hippocampus as a functional model for 5-HT1A receptors (EC50 = 390 nM). It is also a β1-AR antagonist that inhibits the positive chronotropic response induced by isoproterenol in isolated rat atria (pA2 = 6.05). Urapidil (1 μmol/kg, i.v.) lowers mean arterial pressure (MAP) in anesthetized cats, an effect that is reduced by central administration of the 5-HT1A receptor antagonist spiroxatrine.

Chemical Properties

White to Off-White Crystalline Powder

Uses

α1-Adrenergic antagonist; derivative of Uracil (U801000). Antihypertensive.

Uses

Antihypertensive;Serotonergic receptor agonist

Uses

a1-Adrenergic antagonist; derivative of Uracil. Antihypertensive

Biological Activity

α 1 -adrenoceptor antagonist and 5-HT 1A receptor agonist (pIC 50 values are 6.13 and 6.4 respectively). Clinically used hypotensive agent.

Side effects

Side effects that may occur during treatment with uradil antihypertension include dizziness, fatigue, nausea, and light-headedness effects. The increases in systolic blood pressure heart rate caused by three progressive work loads bicycle exercise were not affected during urapidil, A slight reduction in forced expiratory volume was observed in some patients during treatment with beta-blocker. There was no case orthostatic hypotension during urapidil administration, despite its alpha1-blocking action. Side-effects were rare negligible[1].

References

[1] G LEONETTI. Comparison of the antihypertensive effect of urapidil and metoprolol in hypertension.[J]. European Journal of Clinical Pharmacology, 1986, 30 6: 637-640. DOI:10.1007/BF00608208.

Urapidil hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Urapidil hydrochloride Suppliers

Canada 1 China 186 Germany 2 India 4 Switzerland 1 United Kingdom 1 United States 20 Global 215
Tianjin Hankang Pharmaceutical Biotechnology Co. Ltd
Tel
22-23256366 15620629054
Email
ivyding@drughk.com
Country
China
ProdList
13
Advantage
58
Chengdu Aupone Pharmaceutical Co.,Ltd.
Tel
18980796919
Email
236656639@qq.com
Country
China
ProdList
30
Advantage
58
Pushan Industry (Shaanxi) Co., Ltd.
Tel
029-81310890 13571859809
Email
info@pushanshiye.com
Country
China
ProdList
10002
Advantage
58
Wuhan ze shan cheng Biomedical Technology Co., Ltd.
Tel
027-51477051 17786425391
Fax
027-51477052
Email
jim@zeshancheng.com
Country
China
ProdList
371
Advantage
58
Hunan Tengyu New Materials Co., Ltd.
Tel
1822-9738810 18229738810
Email
3590064534@qq.com
Country
China
ProdList
97
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94838
Advantage
76
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15848
Advantage
69
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
zhangsn@titansci.com
Country
China
ProdList
14113
Advantage
59
LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2127
Advantage
70
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32344
Advantage
50
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View Lastest Price from Urapidil hydrochloride manufacturers

Ouhuang Engineering Materials (Hubei) Co., Ltd
Product
Urapidil Hydrochloride 64887-14-5
Price
US $30.00/kg
Min. Order
1kg
Purity
99.7%
Supply Ability
200000kg
Release date
2024-04-18
Ouhuang Engineering Materials (Hubei) Co., Ltd
Product
Urapidil Hydrochloride 64887-14-5
Price
US $50.00/kg
Min. Order
1kg
Purity
99.912%
Supply Ability
10ton
Release date
2024-04-12
Ouhuang Engineering Materials (Hubei) Co., Ltd
Product
Urapidil hydrochloride 64887-14-5
Price
US $50.00/kg
Min. Order
1kg
Purity
99.10%
Supply Ability
50000kg
Release date
2024-04-16

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  • 3-methyl-3-hydroxymethyloxyheterocyclobutane
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  • Urapidil HCl,Urapidil Hydrochloride
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  • 64887-14-5
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  • 64887-14-5