Urapidil hydrochloride
- Product Name
- Urapidil hydrochloride
- CAS No.
- 64887-14-5
- Chemical Name
- Urapidil hydrochloride
- Synonyms
- URAPIDIL HCL;Urapidil hydrochoride;URAPIDIL HYDROCHLORIDE;Eposin Etopophos Vepesid VP16;Urapidil hydrochloride USP/EP/BP;Urapidil HCl,Urapidil Hydrochloride;3-methyl-3-hydroxymethyloxyheterocyclobutane;URAPIDIL HYDROCHLORIDE A1 ADRENOCEPTOR A NTAG;6[[3-[4-(O-METHOXYPHENYL)-1-PIPERAZINYL]PROPYL]AMINO]-1,3-DIMETHYLURACIL HYDROCHLORIDE;6-[[3-[4-(2-Methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyluracil hydrochloride
- CBNumber
- CB6332466
- Molecular Formula
- C20H30ClN5O3
- Formula Weight
- 423.94
- MOL File
- 64887-14-5.mol
Urapidil hydrochloride Property
- Melting point:
- 156-1580C
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- H2O: soluble
- form
- solid
- color
- white
- Water Solubility
- Soluble to 50 mM in water
- InChI
- InChI=1S/C20H29N5O3.ClH/c1-22-18(15-19(26)23(2)20(22)27)21-9-6-10-24-11-13-25(14-12-24)16-7-4-5-8-17(16)28-3;/h4-5,7-8,15,21H,6,9-14H2,1-3H3;1H
- InChIKey
- KTMLZVUAXJERAT-UHFFFAOYSA-N
- SMILES
- O(C1C=CC=CC=1N1CCN(CCCNC2=CC(=O)N(C)C(=O)N2C)CC1)C.Cl
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-36/37/38
- Safety Statements
- 26-36
- WGK Germany
- 3
- RTECS
- YQ9862000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- U100
- Product name
- Urapidil hydrochloride
- Purity
- solid
- Packaging
- 100mg
- Price
- $173
- Updated
- 2023/06/20
- Product number
- U100
- Product name
- Urapidil hydrochloride
- Purity
- solid
- Packaging
- 500mg
- Price
- $691
- Updated
- 2023/06/20
- Product number
- J63219
- Product name
- Urapidil hydrochloride, 98+%
- Packaging
- 1g
- Price
- $191
- Updated
- 2023/06/20
- Product number
- J63219
- Product name
- Urapidil hydrochloride, 98+%
- Packaging
- 5g
- Price
- $605
- Updated
- 2021/12/16
- Product number
- 29004
- Product name
- Urapidil (hydrochloride)
- Packaging
- 250mg
- Price
- $73
- Updated
- 2024/03/01
Urapidil hydrochloride Chemical Properties,Usage,Production
Description
Urapidil is an antagonist of α1-adrenergic receptors (α1-ARs) and a partial agonist of the serotonin (5-HT) receptor subtype 5-HT1A. It selectively binds to α1- over α2-ARs (IC50s = 0.74 and 42 μM, respectively) and to 5-HT1A over 5-HT1B and 5-HT2 receptors (IC50s = 0.4, 20.4, and >10 μM, respectively) in rat cortex. Urapidil inhibits cAMP accumulation induced by forskolin in calf hippocampus as a functional model for 5-HT1A receptors (EC50 = 390 nM). It is also a β1-AR antagonist that inhibits the positive chronotropic response induced by isoproterenol in isolated rat atria (pA2 = 6.05). Urapidil (1 μmol/kg, i.v.) lowers mean arterial pressure (MAP) in anesthetized cats, an effect that is reduced by central administration of the 5-HT1A receptor antagonist spiroxatrine.
Chemical Properties
White to Off-White Crystalline Powder
Uses
α1-Adrenergic antagonist; derivative of Uracil (U801000). Antihypertensive.
Uses
Antihypertensive;Serotonergic receptor agonist
Uses
a1-Adrenergic antagonist; derivative of Uracil. Antihypertensive
Biological Activity
α 1 -adrenoceptor antagonist and 5-HT 1A receptor agonist (pIC 50 values are 6.13 and 6.4 respectively). Clinically used hypotensive agent.
Side effects
Side effects that may occur during treatment with uradil antihypertension include dizziness, fatigue, nausea, and light-headedness effects. The increases in systolic blood pressure heart rate caused by three progressive work loads bicycle exercise were not affected during urapidil, A slight reduction in forced expiratory volume was observed in some patients during treatment with beta-blocker. There was no case orthostatic hypotension during urapidil administration, despite its alpha1-blocking action. Side-effects were rare negligible[1].
References
[1] G LEONETTI. Comparison of the antihypertensive effect of urapidil and metoprolol in hypertension.[J]. European Journal of Clinical Pharmacology, 1986, 30 6: 637-640. DOI:10.1007/BF00608208.
Urapidil hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Urapidil hydrochloride Suppliers
View Lastest Price from Urapidil hydrochloride manufacturers
- Product
- Urapidil Hydrochloride 64887-14-5
- Price
- US $30.00/kg
- Min. Order
- 1kg
- Purity
- 99.7%
- Supply Ability
- 200000kg
- Release date
- 2024-04-18
- Product
- Urapidil Hydrochloride 64887-14-5
- Price
- US $50.00/kg
- Min. Order
- 1kg
- Purity
- 99.912%
- Supply Ability
- 10ton
- Release date
- 2024-04-12
- Product
- Urapidil hydrochloride 64887-14-5
- Price
- US $50.00/kg
- Min. Order
- 1kg
- Purity
- 99.10%
- Supply Ability
- 50000kg
- Release date
- 2024-04-16