ChemicalBook > CAS DataBase List > 6-[[3-[4-(2-Methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyluracil

6-[[3-[4-(2-Methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyluracil

Product Name
6-[[3-[4-(2-Methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyluracil
CAS No.
34661-75-1
Chemical Name
6-[[3-[4-(2-Methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyluracil
Synonyms
URAPIDIL;ebrantil;BKU;b-66256;Eupressyl;Mediatensyl;Urapidil Urapidil;UrapidilC20H29N503;4-dichlorophenoxyacetate;4-Dichlorophenoxyaceticacidsodiumsalt
CBNumber
CB8305730
Molecular Formula
C20H29N5O3
Formula Weight
387.48
MOL File
34661-75-1.mol
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6-[[3-[4-(2-Methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyluracil Property

Melting point:
156-158°
Boiling point:
513.42°C (rough estimate)
Density 
1.2058 (rough estimate)
refractive index 
1.7600 (estimate)
storage temp. 
Sealed in dry,Room Temperature
solubility 
DMSO: 25 mg/mL (64.52 mM); Water: < 0.1 mg/mL (insoluble)
form 
powder to crystal
pka
7.10(at 25℃)
color 
White to Light yellow to Light orange
λmax
268nm(MeOH)(lit.)
Merck 
14,9865
CAS DataBase Reference
34661-75-1(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
22-36/37/38
Safety Statements 
26
RTECS 
YQ9862000
HS Code 
2933.59.8000
Toxicity
LD50 in male mice, rats (mg/kg): 750, 550 orally; 260, 145 i.v. (Koenig)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical
Product number
U0085
Product name
Urapidil
Purity
>98.0%(HPLC)(T)
Packaging
1g
Price
$30
Updated
2024/03/01
TCI Chemical
Product number
U0085
Product name
Urapidil
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$136
Updated
2023/06/20
Usbiological
Product number
291851
Product name
Urapidil
Packaging
50mg
Price
$352
Updated
2021/12/16
TRC
Product number
U815403
Product name
Urapidil
Packaging
2.5g
Price
$1000
Updated
2021/12/16
Chem-Impex
Product number
38345
Product name
Urapidil,95%(HPLC)
Purity
95%(HPLC)
Packaging
5G
Price
$471.52
Updated
2021/12/16
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6-[[3-[4-(2-Methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyluracil Chemical Properties,Usage,Production

Originator

Ebrantil,Byk Gulden,W. Germany,1978

Uses

antihypertensive

Uses

Urapidil is used in preparation of Urapidil Hydrochloride crystal.It is used in diagnosis and treatment of hypertensive emergencies and urgencies among Italian emergency and intensive care departments.

Definition

ChEBI: Urapidil is a member of piperazines.

Manufacturing Process

20.6 g (0.083 mol) of N-(o-methoxyphenyl)-N'-(3-aminopropyl)-piperazine and 15.7 g (0.09 mol) of 1,3-dimethyl-4-chlorouracil were boiled for 15 hours in 100 ml triethylamine. The excess triethylamine was then distilled off in vacuo and the residue was dissolved in 300 ml 1 N hydrochloric acid with subsequent filtration. The filtrate thus obtained was cooled with ice and 2 N aqueous ammonic solution was slowly added with stirring. As soon as the first precipitation appeared, a few crystals of the desired product were added to the solution. The ammoniacal suspension was stirred for one more hour, the precipitate filtered off by suction and washed with 200 ml water.
The material was purified by recrystallization from ethanol with the addition of activated carbon. In this manner 242 g 1,3-dimethyl-4-[γ-[4-(o_x0002_methoxyphenyl]-piperizinyl-(1)]propylamino] uracil having a melting point of 156°C were obtained corresponding to a yield of 75%. The purification may also be effected by boiling the material in acetone to result in similar yields.

Therapeutic Function

Hypotensive

6-[[3-[4-(2-Methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyluracil Preparation Products And Raw materials

Raw materials

Preparation Products

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6-[[3-[4-(2-Methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyluracil Suppliers

Heilongjiang Fuhe Pharmaceutical Group Co., Ltd.
Tel
0455-7707777
Email
fuhejituan@163.com
Country
China
ProdList
8
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58
Huadong Medicine (Xi'an)Bodyguard Pharmaceutical Co.,Ltd.
Tel
029-86638659 18109298458
Email
50844069@qq.com
Country
China
ProdList
17
Advantage
58
Chengdu Saint - Kay Biotechnology Co., Ltd.
Tel
028-85157043 15882256948
Email
676046971@qq.com
Country
China
ProdList
4391
Advantage
58
Tiantai Yisheng Biochemical Technology Co., Ltd
Tel
18958639818微信同号尽量微信不要电话
Email
156697457@qq.com
Country
China
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58
BOYAN PHARMA
Tel
18915538011
Email
liwei@boyanpharma.com
Country
China
ProdList
102
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58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
Fax
001-617-206-9595
Email
sales@chemreagents.com
Country
United States
ProdList
10186
Advantage
62
Shanghai Boc Chemical Co.,Ltd
Tel
021-34975603-808 18721111801
Fax
+86-21-34975602-805
Email
sales@bocpharma.com
Country
China
ProdList
995
Advantage
64
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View Lastest Price from 6-[[3-[4-(2-Methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyluracil manufacturers

Hebei Yanxi Chemical Co., Ltd.
Product
Urapidil 34661-75-1
Price
US $40.00-10.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20 tons
Release date
2023-09-18
airuikechemical co., ltd.
Product
Urapidil 34661-75-1
Price
US $0.00-0.00/Kg
Min. Order
1Kg
Purity
99.9%
Supply Ability
200tons
Release date
2024-04-09
Baoji Guokang Healthchem co.,ltd
Product
Urapidil 34661-75-1
Price
US $4444.40-158.70/g/Bag
Min. Order
1g/Bag
Purity
99%
Supply Ability
80kg
Release date
2021-06-03

34661-75-1, 6-[[3-[4-(2-Methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyluracilRelated Search:


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  • 1,3-Dimethyl-6-[3-[4-(o-methoxyphenyl)piperazin-1-yl]propylamino]uracil
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  • Eupressyl
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  • 4-dichlorophenoxyacetate
  • 4-Dichlorophenoxyaceticacidsodiumsalt
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  • API
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  • 34661-75-1