ChemicalBook > CAS DataBase List > 6-[[3-[4-(2-Methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyluracil

6-[[3-[4-(2-Methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyluracil

Product Name
6-[[3-[4-(2-Methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyluracil
CAS No.
34661-75-1
Chemical Name
6-[[3-[4-(2-Methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyluracil
Synonyms
URAPIDIL;ebrantil;BKU;b-66256;Eupressyl;Mediatensyl;Urapidil Urapidil;UrapidilC20H29N503;4-dichlorophenoxyacetate;4-Dichlorophenoxyaceticacidsodiumsalt
CBNumber
CB8305730
Molecular Formula
C20H29N5O3
Formula Weight
387.48
MOL File
34661-75-1.mol
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6-[[3-[4-(2-Methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyluracil Property

Melting point:
156-158°
Boiling point:
513.42°C (rough estimate)
Density 
1.2058 (rough estimate)
refractive index 
1.7600 (estimate)
storage temp. 
Sealed in dry,Room Temperature
solubility 
DMSO: 25 mg/mL (64.52 mM); Water: < 0.1 mg/mL (insoluble)
form 
powder to crystal
pka
7.10(at 25℃)
color 
White to Light yellow to Light orange
λmax
268nm(MeOH)(lit.)
Merck 
14,9865
CAS DataBase Reference
34661-75-1(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
22-36/37/38
Safety Statements 
26
RTECS 
YQ9862000
HS Code 
2933.59.8000
Toxicity
LD50 in male mice, rats (mg/kg): 750, 550 orally; 260, 145 i.v. (Koenig)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical
Product number
U0085
Product name
Urapidil
Purity
>98.0%(HPLC)(T)
Packaging
1g
Price
$30
Updated
2024/03/01
TCI Chemical
Product number
U0085
Product name
Urapidil
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$136
Updated
2023/06/20
Usbiological
Product number
291851
Product name
Urapidil
Packaging
50mg
Price
$352
Updated
2021/12/16
TRC
Product number
U815403
Product name
Urapidil
Packaging
2.5g
Price
$1000
Updated
2021/12/16
Chem-Impex
Product number
38345
Product name
Urapidil,95%(HPLC)
Purity
95%(HPLC)
Packaging
5G
Price
$471.52
Updated
2021/12/16
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6-[[3-[4-(2-Methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyluracil Chemical Properties,Usage,Production

Originator

Ebrantil,Byk Gulden,W. Germany,1978

Uses

antihypertensive

Uses

Urapidil is used in preparation of Urapidil Hydrochloride crystal.It is used in diagnosis and treatment of hypertensive emergencies and urgencies among Italian emergency and intensive care departments.

Definition

ChEBI: Urapidil is a member of piperazines.

Manufacturing Process

20.6 g (0.083 mol) of N-(o-methoxyphenyl)-N'-(3-aminopropyl)-piperazine and 15.7 g (0.09 mol) of 1,3-dimethyl-4-chlorouracil were boiled for 15 hours in 100 ml triethylamine. The excess triethylamine was then distilled off in vacuo and the residue was dissolved in 300 ml 1 N hydrochloric acid with subsequent filtration. The filtrate thus obtained was cooled with ice and 2 N aqueous ammonic solution was slowly added with stirring. As soon as the first precipitation appeared, a few crystals of the desired product were added to the solution. The ammoniacal suspension was stirred for one more hour, the precipitate filtered off by suction and washed with 200 ml water.
The material was purified by recrystallization from ethanol with the addition of activated carbon. In this manner 242 g 1,3-dimethyl-4-[γ-[4-(o_x0002_methoxyphenyl]-piperizinyl-(1)]propylamino] uracil having a melting point of 156°C were obtained corresponding to a yield of 75%. The purification may also be effected by boiling the material in acetone to result in similar yields.

Therapeutic Function

Hypotensive

6-[[3-[4-(2-Methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyluracil Preparation Products And Raw materials

Raw materials

Preparation Products

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6-[[3-[4-(2-Methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyluracil Suppliers

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View Lastest Price from 6-[[3-[4-(2-Methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyluracil manufacturers

airuikechemical co., ltd.
Product
Urapidil 34661-75-1
Price
US $0.00-0.00/Kg
Min. Order
1Kg
Purity
99.9%
Supply Ability
200tons
Release date
2024-04-09
Hebei Yanxi Chemical Co., Ltd.
Product
Urapidil 34661-75-1
Price
US $40.00-10.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20 tons
Release date
2023-09-18
Hebei Lingding Biotechnology Co., Ltd.
Product
Urapidil 34661-75-1
Price
US $15.00-12.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
9000kg/per week
Release date
2021-11-15

34661-75-1, 6-[[3-[4-(2-Methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyluracilRelated Search:

Urapidil hydrochloride 1-(2-Methoxyphenyl)piperazine 6-amino-1,5-dimethylpyrimidine-2,4(1H,3H)-dione URAPIDIL 5-METHYL- Urapidil N-Oxide 6-METHYLAMINO-1,3-DIMETHYLURACIL 1-(3-Methoxyphenyl)piperazine 1-(3-AMinopropyl)-4-(2-Methoxyphenyl)piperazine 97% 4-(3-Hydroxypropylamino)-1,3-dimethyluracil O-DesMethyl Urapidil 6-[(3-chloropropyl)amino]-1,3-dimethyluracil 2-Demethoxy-2-chloro urapidil Urapidil impurity 7 1,3-Dimethylbarbituric acid 2-Demethoxy-4-methoxy urapidil 6-Amino-1,3-dimethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione 6-[[3-[4-(2-Methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyluracil 1,3-Dimethylurea

  • 1,3-dimethyl-6-(3-(4-(o-methoxyphenyl)-1-piperazinyl)proppylamino)-uraci
  • 6-(3-(4-(o-methoxyphenyl)-1-piperazinyl)propylamino)-1,3-dimethyluracil
  • b-66256
  • ebrantil
  • 6-[3-[4-(2-methoxyphenyl)piperazin-1-yl]propylamino]-1,3-dimethylpyrimidine-2,4-dione
  • 6-[3-[4-(2-methoxyphenyl)-1-piperazinyl]propylamino]-1,3-dimethylpyrimidine-2,4-dione
  • URAPIDIL
  • 6-[[3-[4-(2-methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyluracil
  • UrapidilC20H29N503
  • URAPIDIL [6-((3-(4-(2-METHOXYPHENYL)-1-PIPERAZINYL)PROPYL)AMINO)-1,3-DIMETHYLURACIL]
  • 1,3-Dimethyl-6-[3-[4-(o-methoxyphenyl)piperazin-1-yl]propylamino]uracil
  • BKU
  • 6-((3-(4-(2-Methoxyphenyl)piperazin-1-yl)propyl)aMino)-1,3-diMethylpyriMidine-2,4(1H,3H)-dione
  • 2,4(1H,3H)-PyriMidinedione,6-[[3-[4-(2-Methoxyphenyl)-1-piperazinyl]propyl]aMino]-1,3-diMethyl-
  • Urapidil Urapidil
  • Mediatensyl
  • Eupressyl
  • 6-[[3-[4-(2-Methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyluracil USP/EP/BP
  • UrapidilQ: What is Urapidil Q: What is the CAS Number of Urapidil Q: What is the storage condition of Urapidil Q: What are the applications of Urapidil
  • 4-dichlorophenoxyacetate
  • 4-Dichlorophenoxyaceticacidsodiumsalt
  • 34661-75-1
  • C20H29N5O3
  • EBRANTIL
  • API
  • API's
  • 34661-75-1