6-Amino-1,3-dimethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione

Product Name: 6-Amino-1,3-dimethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione
CAS No.: 6642-31-5
Chemical Name: 6-Amino-1,3-dimethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione
Synonyms: 6-AMINO-1,3-DIMETHYLURACIL;6-AMINO-1,3-DIMETHYLPYRIMIDINE-2,4(1H,3H)-DIONE;6-AMINO-1,3-DIMETHYLURICIL;AURORA KA-4912;Uradil impurity 42;TIMTEC-BB SBB004028;SPECS AB-323/25048015;Dimethyl- 6-aminouracil;Chlorpyrifos Impurity 21;1,3-DIMETHYL-4-AMINOURACIL
CBNumber: CB4775315
Molecular Formula: C6H9N3O2
Formula Weight: 155.15
MOL File: 6642-31-5.mol

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6-Amino-1,3-dimethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione Property

Melting point:: 295 °C (dec.) (lit.)
Boiling point:: 243.1±43.0 °C(Predicted)
Density: 1.288±0.06 g/cm3(Predicted)
vapor pressure: 0Pa at 25℃
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: 6g/l
form: Solid
pka: 5.17±0.70(Predicted)
color: Pale Beige
PH: 6.9 (100g/l, H2O, 20℃)
Water Solubility: 7.06g/L(25 ºC)
InChIKey: VFGRNTYELNYSKJ-UHFFFAOYSA-N
LogP: -0.4 at 20℃
CAS DataBase Reference: 6642-31-5(CAS DataBase Reference)
EPA Substance Registry System: 2,4(1H,3H)-Pyrimidinedione, 6-amino-1,3-dimethyl- (6642-31-5)

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Safety

Hazard Codes: Xn
Risk Statements: 22-36/37/38
Safety Statements: 22-26-36/37/39
WGK Germany: 1
RTECS: YQ8755000
HS Code: 29335990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: A52153
Product name: 6-Amino-1,3-dimethyluracil
Purity: 98%
Packaging: 100g
Price: $115
Updated: 2025/07/31

TCI Chemical

Product number: A1420
Product name: 6-Amino-1,3-dimethyluracil
Purity: >98.0%(HPLC)(T)
Packaging: 25g
Price: $34
Updated: 2025/07/31

TCI Chemical

Product number: A1420
Product name: 6-Amino-1,3-dimethyluracil
Purity: >98.0%(HPLC)(T)
Packaging: 500g
Price: $302
Updated: 2025/07/31

TRC

Product number: A607750
Product name: 6-Amino-1,3-dimethyluracil
Packaging: 100g
Price: $130
Updated: 2021/12/16

TRC

Product number: A607750
Product name: 6-Amino-1,3-dimethyluracil
Packaging: 250g
Price: $180
Updated: 2021/12/16

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6-Amino-1,3-dimethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione Chemical Properties,Usage,Production

Chemical Properties

Crystallizes (water). Melting point 295°C (293°C). Decomposes.

Uses

6-Amino-1,3-dimethyluracil is used as a reagent in the synthesis of new pyrimidine and caffeine derivatives that display highly potential antitumor activity. It is also used as a starting material in the synthesis of fused pyrido-pyrimidines.

Synthesis

873-83-6

74-88-4

6642-31-5

General procedure for the synthesis of 1,3-dimethyl-6-aminouracil from 4-amino-2,6-dihydroxypyrimidine and iodomethane: 4-amino-2,6-dihydroxypyrimidine (1.27 g, 10 mmol) was added to a pre-heated ethanol solution (50 ml) containing KOH (0.56 g, 10 mmol) and heated continuously for 40 min. After completion of the reaction, the mixture was cooled to room temperature followed by addition of iodomethane (20 mmol). The reaction mixture was stirred under heating conditions for 8 hours, after which it was cooled to room temperature. The reaction mixture was poured into cold distilled water (100 ml) to induce precipitation of the final product 1,3-dimethyl-6-aminouracil. The precipitate was collected by filtration and washed with distilled water (100 ml). Finally, recrystallization from methanol gave 1,3-dimethyl-6-aminouracil in yellow crystalline form.

References

[1] Letters in Drug Design and Discovery, 2015, vol. 12, # 6, p. 471 - 478
[2] DRP/DRBP Org.Chem.,
[3] Patent: CN104744471, 2016, B. Location in patent: Paragraph 0026; 0027; 0028

6-Amino-1,3-dimethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione Preparation Products And Raw materials

Raw materials

2-cyano-N-methyl-N-[(methylamino)carbonyl]acetamide Acetic anhydride 1,3-Dimethylurea

Preparation Products

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6-Amino-1,3-dimethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione Suppliers

Americas 1 Austria 1 Belgium 2 China 354 Europe 3 Germany 7 India 23 Japan 2 Russia 1 Slovakia 1 Switzerland 1 The Netherlands 1 Ukraine 2 United Kingdom 12 United States 32 USA 1 Global 444

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View Lastest Price from 6-Amino-1,3-dimethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione manufacturers

Zouping mingyuan import & export trading co., ltd

Product: 6-Amino-1,3-dimethyluracil 6642-31-5
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99
Supply Ability: 20 tons
Release date: 2025-08-05

Hebei Chuanghai Biotechnology Co., Ltd

Product: 6-Amino-1,3-dimethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione 6642-31-5
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 5tons
Release date: 2024-12-03

Hebei Zhuanglai Chemical Trading Co Ltd

Product: 6-Amino-1,3-dimethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione 6642-31-5
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20 ton
Release date: 2024-12-09

6642-31-5, 6-Amino-1,3-dimethyl-1,2,3,4-tetrahydropyrimidine-2,4-dioneRelated Search:

1,3,7-TRIMETHYLURIC ACID aminometradine 1,3-Dimethylurea 6-AMINO-1,3-DIMETHYL-5-NITROSOURACIL 5,6-Diamino-1,3-dimethyluracil hydrate 6-Amino-1,3-dimethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione 1,3-Dimethyluric acid 6-[[3-[4-(2-Methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyluracil TETRAMETHYLURIC ACID Semicarbazide 1,3-Dimethyluracil 6-Aminouracil 1,3-DIMETHYL-6-HYDRAZINOURACIL 6-AMINO-1,3-DIMETHYL-2,4-DIOXO-1,2,3,4-TETRAHYDROPYRIMIDINE-5-CARBALDEHYDE 1,3-DIETHYL-5-NITROSO-6-AMINOURACIL 1,3-DIETHYL-5,6-DIAMINOURACIL 6-AMino-1-isobutyl-3-Methyl-5-nitroso-2,4-pyriMidinedione 1,3-DIETHYL-6-AMINOURACIL

AURORA KA-4912

1,3-DIMETHYL-6-AMINOURACIL

1,3-DIMETHYL-4-AMINOURACIL

1,3-DIMETHYL-2,6-DIOXO-4-AMINOTETRAHYDROPYRIMIDINE

4-AMINO-1,3-DIMETHYLURACIL FOR SYNTHESIS

6-AMINO-1,3-DIMETHYLPYRIMIDINE-2,4(1H,3H)-DIONE

6-AMINO-1,3-DIMETHYLURACIL

6-AMINO-1,3-DIMETHYLURICIL

6-AMINO-1,3-DIMETHYL-1,2,3,4-TETRAHYDROPYRIMIDINE-2,4-DIONE

2,4(1H,3H)-Pyrimidinedione, 6-amino-1,3-dimethyl-

4-AMINO-1,3-DIMETHYLURACIL 98+%

6-AMINO-1,3-DIMETHYLURACIL6-AMINO-1,3-DIMETHYL-2,4(1H,3H)-PYRIMIDINEDIONE

3-(4-Nitrophenyl)propionicacidC9H9NO4

6-AMINO-1,3-DIMETHYLURACIL、6-AMINO-1,3-DIMETHYL-2,4(1H,3H)-DIONE

Amino-1,3-dimethyluracil,6-

1,3-Dimethyl-6-amino-1,2,3,4-tetrahydropyrimidine-2,4-dione

1,3-Dimethyl-6-amino-2,4(1H,3H)-pyrimidinedione

6-AMINO-1,3-DIMETHYL-1,2,3,4-TETR

4-AMINO-1,3-DIMETHYL-2,6-DIHYDROXYPYRIMIDINE

4-AMINO-1,3-DIMETHYLURACIL

TIMTEC-BB SBB004028

SPECS AB-323/25048015

3h)-pyrimidinedione,6-amino-1,3-dimethyl-4(1h

6-amino-1,3-dimethyl-2,4(1h,3h)-pyrimidinedione

6-Amino-1,3-dimethyl-2,4-pyrimidinedione

6-amino-1,3-dimethyl-uraci

6-Imino-1,3-dimethyluracil

6-AMINO-1,3-DIMETHYL-2,4(1H,3H)-DIONE

Dimethyl- 6-aminouracil

6-amino-1,3-dimethylpyrimidine-2,4-dione

6-Amino-1,3-dimethyluracil &gt

Chlorpyrifos Impurity 21

6-Amino-1,3-di methyluracil in Acetonitrile

Uradil impurity 42

6-Amino-1,3-dimetyl uracil

6642-31-5

4316-44-9

Heterocyclic Building Blocks

Pyrimidines

Building Blocks

Amines

Building Blocks

Heterocyclic Building Blocks

Pyrimidines

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