ChemicalBook > CAS DataBase List > 6-Amino-1,3-dimethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione

6-Amino-1,3-dimethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione

Product Name
6-Amino-1,3-dimethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione
CAS No.
6642-31-5
Chemical Name
6-Amino-1,3-dimethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione
Synonyms
6-AMINO-1,3-DIMETHYLURACIL;6-AMINO-1,3-DIMETHYLPYRIMIDINE-2,4(1H,3H)-DIONE;6-AMINO-1,3-DIMETHYLURICIL;AURORA KA-4912;Uradil impurity 42;TIMTEC-BB SBB004028;SPECS AB-323/25048015;Dimethyl- 6-aminouracil;Chlorpyrifos Impurity 21;1,3-DIMETHYL-4-AMINOURACIL
CBNumber
CB4775315
Molecular Formula
C6H9N3O2
Formula Weight
155.15
MOL File
6642-31-5.mol
More
Less

6-Amino-1,3-dimethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione Property

Melting point:
295 °C (dec.) (lit.)
Boiling point:
243.1±43.0 °C(Predicted)
Density 
1.288±0.06 g/cm3(Predicted)
vapor pressure 
0Pa at 25℃
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
6g/l
form 
Solid
pka
5.17±0.70(Predicted)
color 
Pale Beige
PH
6.9 (100g/l, H2O, 20℃)
Water Solubility 
7.06g/L(25 ºC)
InChIKey
VFGRNTYELNYSKJ-UHFFFAOYSA-N
LogP
-0.4 at 20℃
CAS DataBase Reference
6642-31-5(CAS DataBase Reference)
EPA Substance Registry System
2,4(1H,3H)-Pyrimidinedione, 6-amino-1,3-dimethyl- (6642-31-5)
More
Less

Safety

Hazard Codes 
Xn
Risk Statements 
22-36/37/38
Safety Statements 
22-26-36/37/39
WGK Germany 
1
RTECS 
YQ8755000
HS Code 
29335990
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A52153
Product name
6-Amino-1,3-dimethyluracil
Purity
98%
Packaging
100g
Price
$115
Updated
2025/07/31
TCI Chemical
Product number
A1420
Product name
6-Amino-1,3-dimethyluracil
Purity
>98.0%(HPLC)(T)
Packaging
25g
Price
$34
Updated
2025/07/31
TCI Chemical
Product number
A1420
Product name
6-Amino-1,3-dimethyluracil
Purity
>98.0%(HPLC)(T)
Packaging
500g
Price
$302
Updated
2025/07/31
TRC
Product number
A607750
Product name
6-Amino-1,3-dimethyluracil
Packaging
100g
Price
$130
Updated
2021/12/16
TRC
Product number
A607750
Product name
6-Amino-1,3-dimethyluracil
Packaging
250g
Price
$180
Updated
2021/12/16
More
Less

6-Amino-1,3-dimethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione Chemical Properties,Usage,Production

Chemical Properties

Crystallizes (water). Melting point 295°C (293°C). Decomposes.

Uses

6-Amino-1,3-dimethyluracil is used as a reagent in the synthesis of new pyrimidine and caffeine derivatives that display highly potential antitumor activity. It is also used as a starting material in the synthesis of fused pyrido-pyrimidines.

Synthesis

873-83-6

74-88-4

6642-31-5

General procedure for the synthesis of 1,3-dimethyl-6-aminouracil from 4-amino-2,6-dihydroxypyrimidine and iodomethane: 4-amino-2,6-dihydroxypyrimidine (1.27 g, 10 mmol) was added to a pre-heated ethanol solution (50 ml) containing KOH (0.56 g, 10 mmol) and heated continuously for 40 min. After completion of the reaction, the mixture was cooled to room temperature followed by addition of iodomethane (20 mmol). The reaction mixture was stirred under heating conditions for 8 hours, after which it was cooled to room temperature. The reaction mixture was poured into cold distilled water (100 ml) to induce precipitation of the final product 1,3-dimethyl-6-aminouracil. The precipitate was collected by filtration and washed with distilled water (100 ml). Finally, recrystallization from methanol gave 1,3-dimethyl-6-aminouracil in yellow crystalline form.

References

[1] Letters in Drug Design and Discovery, 2015, vol. 12, # 6, p. 471 - 478
[2] DRP/DRBP Org.Chem.,
[3] Patent: CN104744471, 2016, B. Location in patent: Paragraph 0026; 0027; 0028

6-Amino-1,3-dimethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione Preparation Products And Raw materials

Raw materials

2-cyano-N-methyl-N-[(methylamino)carbonyl]acetamide Acetic anhydride 1,3-Dimethylurea

Preparation Products

More
Less

6-Amino-1,3-dimethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione Suppliers

Americas 1 Austria 1 Belgium 2 China 354 Europe 3 Germany 7 India 23 Japan 2 Russia 1 Slovakia 1 Switzerland 1 The Netherlands 1 Ukraine 2 United Kingdom 12 United States 32 USA 1 Global 444
TCI EUROPE N.V.
Tel
--
Fax
--
Email
sales@tcieurope.be
Country
Belgium
ProdList
2200
Advantage
66
Maybridge Chemical Co., Ltd.
Tel
--
Fax
--
Country
Belgium
ProdList
6293
Advantage
73
More
Less

View Lastest Price from 6-Amino-1,3-dimethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione manufacturers

Zouping mingyuan import & export trading co., ltd
Product
6-Amino-1,3-dimethyluracil 6642-31-5
Price
US $0.00/kg
Min. Order
1kg
Purity
99
Supply Ability
20 tons
Release date
2025-08-05
Hebei Chuanghai Biotechnology Co., Ltd
Product
6-Amino-1,3-dimethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione 6642-31-5
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
5tons
Release date
2024-12-03
Hebei Zhuanglai Chemical Trading Co Ltd
Product
6-Amino-1,3-dimethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione 6642-31-5
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20 ton
Release date
2024-12-09

6642-31-5, 6-Amino-1,3-dimethyl-1,2,3,4-tetrahydropyrimidine-2,4-dioneRelated Search:

1,3,7-TRIMETHYLURIC ACID aminometradine 1,3-Dimethylurea 6-AMINO-1,3-DIMETHYL-5-NITROSOURACIL 5,6-Diamino-1,3-dimethyluracil hydrate 6-Amino-1,3-dimethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione 1,3-Dimethyluric acid 6-[[3-[4-(2-Methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyluracil TETRAMETHYLURIC ACID Semicarbazide 1,3-Dimethyluracil 6-Aminouracil 1,3-DIMETHYL-6-HYDRAZINOURACIL 6-AMINO-1,3-DIMETHYL-2,4-DIOXO-1,2,3,4-TETRAHYDROPYRIMIDINE-5-CARBALDEHYDE 1,3-DIETHYL-5-NITROSO-6-AMINOURACIL 1,3-DIETHYL-5,6-DIAMINOURACIL 6-AMino-1-isobutyl-3-Methyl-5-nitroso-2,4-pyriMidinedione 1,3-DIETHYL-6-AMINOURACIL

  • AURORA KA-4912
  • 1,3-DIMETHYL-6-AMINOURACIL
  • 1,3-DIMETHYL-4-AMINOURACIL
  • 1,3-DIMETHYL-2,6-DIOXO-4-AMINOTETRAHYDROPYRIMIDINE
  • 4-AMINO-1,3-DIMETHYLURACIL FOR SYNTHESIS
  • 6-AMINO-1,3-DIMETHYLPYRIMIDINE-2,4(1H,3H)-DIONE
  • 6-AMINO-1,3-DIMETHYLURACIL
  • 6-AMINO-1,3-DIMETHYLURICIL
  • 6-AMINO-1,3-DIMETHYL-1,2,3,4-TETRAHYDROPYRIMIDINE-2,4-DIONE
  • 2,4(1H,3H)-Pyrimidinedione, 6-amino-1,3-dimethyl-
  • 4-AMINO-1,3-DIMETHYLURACIL 98+%
  • 6-AMINO-1,3-DIMETHYLURACIL6-AMINO-1,3-DIMETHYL-2,4(1H,3H)-PYRIMIDINEDIONE
  • 3-(4-Nitrophenyl)propionicacidC9H9NO4
  • 6-AMINO-1,3-DIMETHYLURACIL、6-AMINO-1,3-DIMETHYL-2,4(1H,3H)-DIONE
  • Amino-1,3-dimethyluracil,6-
  • 1,3-Dimethyl-6-amino-1,2,3,4-tetrahydropyrimidine-2,4-dione
  • 1,3-Dimethyl-6-amino-2,4(1H,3H)-pyrimidinedione
  • 6-AMINO-1,3-DIMETHYL-1,2,3,4-TETR
  • 4-AMINO-1,3-DIMETHYL-2,6-DIHYDROXYPYRIMIDINE
  • 4-AMINO-1,3-DIMETHYLURACIL
  • TIMTEC-BB SBB004028
  • SPECS AB-323/25048015
  • 3h)-pyrimidinedione,6-amino-1,3-dimethyl-4(1h
  • 6-amino-1,3-dimethyl-2,4(1h,3h)-pyrimidinedione
  • 6-Amino-1,3-dimethyl-2,4-pyrimidinedione
  • 6-amino-1,3-dimethyl-uraci
  • 6-Imino-1,3-dimethyluracil
  • 6-AMINO-1,3-DIMETHYL-2,4(1H,3H)-DIONE
  • Dimethyl- 6-aminouracil
  • 6-amino-1,3-dimethylpyrimidine-2,4-dione
  • 6-Amino-1,3-dimethyluracil &gt
  • Chlorpyrifos Impurity 21
  • 6-Amino-1,3-di methyluracil in Acetonitrile
  • Uradil impurity 42
  • 6-Amino-1,3-dimetyl uracil
  • 6642-31-5
  • 4316-44-9
  • Heterocyclic Building Blocks
  • Pyrimidines
  • Building Blocks
  • Amines
  • Building Blocks
  • Heterocyclic Building Blocks
  • Pyrimidines
  • bc0001