ChemicalBook > CAS DataBase List > 6-Amino-1,3-dimethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione

6-Amino-1,3-dimethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione

Product Name
6-Amino-1,3-dimethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione
CAS No.
6642-31-5
Chemical Name
6-Amino-1,3-dimethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione
Synonyms
6-AMINO-1,3-DIMETHYLURACIL;6-AMINO-1,3-DIMETHYLPYRIMIDINE-2,4(1H,3H)-DIONE;6-AMINO-1,3-DIMETHYLURICIL;AURORA KA-4912;Uradil impurity 42;TIMTEC-BB SBB004028;SPECS AB-323/25048015;Dimethyl- 6-aminouracil;Chlorpyrifos Impurity 21;1,3-DIMETHYL-4-AMINOURACIL
CBNumber
CB4775315
Molecular Formula
C6H9N3O2
Formula Weight
155.15
MOL File
6642-31-5.mol
More
Less

6-Amino-1,3-dimethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione Property

Melting point:
295 °C (dec.) (lit.)
Boiling point:
243.1±43.0 °C(Predicted)
Density 
1.288±0.06 g/cm3(Predicted)
vapor pressure 
0Pa at 25℃
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
6g/l
form 
Solid
pka
5.17±0.70(Predicted)
color 
Pale Beige
PH
6.9 (100g/l, H2O, 20℃)
Water Solubility 
7.06g/L(25 ºC)
InChIKey
VFGRNTYELNYSKJ-UHFFFAOYSA-N
LogP
-0.4 at 20℃
CAS DataBase Reference
6642-31-5(CAS DataBase Reference)
EPA Substance Registry System
2,4(1H,3H)-Pyrimidinedione, 6-amino-1,3-dimethyl- (6642-31-5)
More
Less

Safety

Hazard Codes 
Xn
Risk Statements 
22-36/37/38
Safety Statements 
22-26-36/37/39
WGK Germany 
1
RTECS 
YQ8755000
HS Code 
29335990
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A52153
Product name
6-Amino-1,3-dimethyluracil
Purity
98%
Packaging
100g
Price
$115
Updated
2025/07/31
TCI Chemical
Product number
A1420
Product name
6-Amino-1,3-dimethyluracil
Purity
>98.0%(HPLC)(T)
Packaging
25g
Price
$34
Updated
2025/07/31
TCI Chemical
Product number
A1420
Product name
6-Amino-1,3-dimethyluracil
Purity
>98.0%(HPLC)(T)
Packaging
500g
Price
$302
Updated
2025/07/31
TRC
Product number
A607750
Product name
6-Amino-1,3-dimethyluracil
Packaging
100g
Price
$130
Updated
2021/12/16
TRC
Product number
A607750
Product name
6-Amino-1,3-dimethyluracil
Packaging
250g
Price
$180
Updated
2021/12/16
More
Less

6-Amino-1,3-dimethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione Chemical Properties,Usage,Production

Chemical Properties

Crystallizes (water). Melting point 295°C (293°C). Decomposes.

Uses

6-Amino-1,3-dimethyluracil is used as a reagent in the synthesis of new pyrimidine and caffeine derivatives that display highly potential antitumor activity. It is also used as a starting material in the synthesis of fused pyrido-pyrimidines.

Synthesis

873-83-6

74-88-4

6642-31-5

General procedure for the synthesis of 1,3-dimethyl-6-aminouracil from 4-amino-2,6-dihydroxypyrimidine and iodomethane: 4-amino-2,6-dihydroxypyrimidine (1.27 g, 10 mmol) was added to a pre-heated ethanol solution (50 ml) containing KOH (0.56 g, 10 mmol) and heated continuously for 40 min. After completion of the reaction, the mixture was cooled to room temperature followed by addition of iodomethane (20 mmol). The reaction mixture was stirred under heating conditions for 8 hours, after which it was cooled to room temperature. The reaction mixture was poured into cold distilled water (100 ml) to induce precipitation of the final product 1,3-dimethyl-6-aminouracil. The precipitate was collected by filtration and washed with distilled water (100 ml). Finally, recrystallization from methanol gave 1,3-dimethyl-6-aminouracil in yellow crystalline form.

References

[1] Letters in Drug Design and Discovery, 2015, vol. 12, # 6, p. 471 - 478
[2] DRP/DRBP Org.Chem.,
[3] Patent: CN104744471, 2016, B. Location in patent: Paragraph 0026; 0027; 0028

6-Amino-1,3-dimethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione Preparation Products And Raw materials

Raw materials

2-cyano-N-methyl-N-[(methylamino)carbonyl]acetamide Acetic anhydride 1,3-Dimethylurea

Preparation Products

More
Less

6-Amino-1,3-dimethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione Suppliers

Americas 1 Austria 1 Belgium 2 China 354 Europe 3 Germany 7 India 23 Japan 2 Russia 1 Slovakia 1 Switzerland 1 The Netherlands 1 Ukraine 2 United Kingdom 12 United States 32 USA 1 Global 444
Shandong Xinhua Pharmceutical Co.,LTD
Tel
0533-0533-2196801
Fax
0533-2196817
Email
yaojianyong@xhzy.com
Country
China
ProdList
70
Advantage
60
Shijiazhuang Kunxiangda Technology Co., Ltd.
Tel
0311-89683399 15373948595
Fax
0311-89683399
Email
sales@kunenchem.com
Country
China
ProdList
20
Advantage
56
Shijiazhuang Kunen Trading Co.,Ltd
Tel
0311-89683399 15373948596
Fax
0311-89683399
Email
sales@kunenchem.com
Country
China
ProdList
42
Advantage
58
Shijiazhuang Feizi Chemical Technology Co. LTD
Tel
0311-85957988 18633001459
Email
sales@feizichem.com
Country
China
ProdList
83
Advantage
58
ZOUPING MINGYUAN IMP.&EXP. TRADE CO.,LTD.
Tel
18364991597
Email
fox793@163.com
Country
China
ProdList
21
Advantage
58
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006356688 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
TAIYUAN RHF CO.,LTD.
Tel
+86 351 7031519
Fax
+86 351 7031519
Email
sales@RHFChem.com
Country
China
ProdList
2338
Advantage
56
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Beijing HwrkChemical Technology Co., Ltd
Tel
18515581800 18501085097
Fax
010-89508210
Email
sales.bj@hwrkchemical.com
Country
China
ProdList
9400
Advantage
55
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44801
Advantage
61
Accela ChemBio Co.,Ltd.
Tel
021-50795510 4000665055
Fax
021-50795055
Email
sales@accelachem.com
Country
China
ProdList
11035
Advantage
64
Shanghai Longsheng chemical Co.,Ltd.
Tel
021-58099652-8005 13585536065
Fax
021-58099609
Email
bin.wu@shlschem.com
Country
China
ProdList
9883
Advantage
59
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42934
Advantage
64
XiaoGan ShenYuan ChemPharm co,ltd
Tel
15527621225
Email
1791901229@qq.com
Country
China
ProdList
6945
Advantage
52
Beijing Isomersyn Technology CO;LTD
Tel
010-82954736 13391601435
Email
sales@isomersyn.com
Country
China
ProdList
3295
Advantage
57
Shandong Xiya Chemical Co., Ltd
Tel
4009903999 13355009207
Fax
0539-6365991
Email
3007715519@qq.com
Country
China
ProdList
18729
Advantage
57
Syntechem Co.,Ltd
Tel
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
12984
Advantage
57
Sichuan Kulinan Technology Co., Ltd
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11705
Advantage
57
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400 638 7771
Email
sales@heowns.com
Country
China
ProdList
14435
Advantage
57
Nanjing Vital Chemical Co., Ltd.
Tel
Please Send Email 18652950785
Fax
025-87193546
Email
chemweiao@163.com
Country
China
ProdList
4378
Advantage
65
Maya High Purity Chemicals
Tel
+86 (573) 82222445 (0)18006601000 452520369
Fax
+86 (573) 82222643
Email
sales@maya-r.com
Country
China
ProdList
11707
Advantage
57
Atop-Pharma (Shanghai) Technology Co., Ltd.
Tel
+86 (21) 5196-9732
Fax
+86 (21) 5196-9733
Country
China
ProdList
996
Advantage
57
Hangzhou Yuhao Chemical Technology Co., Ltd
Tel
0571-82693216
Fax
+86-571-82880190
Email
info@yuhaochemical.com
Country
China
ProdList
6387
Advantage
52
BioBioPha Co., Ltd.
Tel
0871-65217109 13211707573;
Fax
0871-65215563
Email
y.liu@mail.biobiopha.com
Country
China
ProdList
5645
Advantage
65
S.Z. PhyStandard Bio-Tech. Co., Ltd.
Tel
0755-4000505016 13380397412
Fax
0755 28094224
Email
3001272453@qq.com
Country
China
ProdList
5158
Advantage
50
Shanghai Topbiochem Technology Co., Ltd
Tel
021-58170097
Email
info@topbiochem.com
Country
China
ProdList
9510
Advantage
58
Nanjing Norris-Pharm Technology Co., Ltd
Tel
18652989687
Fax
+86-25-52131256
Email
sales@norris-pharm.com
Country
China
ProdList
8878
Advantage
55
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66113011 17798518460
Fax
(1)02557626880
Email
cfzhang@aikonchem.com
Country
China
ProdList
19913
Advantage
55
9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
18209
Advantage
56
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-6206333 13167063860
Fax
021-50323701
Email
anhua.mao@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
Shanghai Raise Chemical Technology Co.,Ltd
Tel
+86-021-50935922
Fax
+86-021-33847795
Country
China
ProdList
7865
Advantage
55
Chengdu AstaTech Trading Co., Ltd./AstaTech (Chengdu) Pharma. Co., Ltd.
Tel
+86-28-85122536 85324413
Fax
+86-28-85326443
Email
market@astatech.cn
Country
China
ProdList
8026
Advantage
55
HuBei ShengBaoLai Biological Technology Co., Ltd
Tel
027-59105235 13007105135
Fax
027-59105235
Email
sbl1120@163.com
Country
China
ProdList
100
Advantage
55
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
39966
Advantage
60
Shandong Zhongke Taidou Chemical Co., Ltd.
Tel
0531-88682301 18595278760
Fax
0531-62325738
Email
sdzkzf@sdzktd.com
Country
China
ProdList
112
Advantage
62
Chengdu HuaXia Chemical Reagent Co. Ltd
Tel
400-1166-196 13458535857
Fax
QQ：800101999
Email
cdhxsj@163.com
Country
China
ProdList
13350
Advantage
58
Hunan HuaTeng Pharmaceutical Co., Ltd.,
Tel
400-8592883
Fax
0731-82251112
Email
sales@huatengsci.com
Country
China
ProdList
5872
Advantage
58
Wuhan Dahua Pharmaceutical Co., Ltd.
Tel
027-59262863 13277907145 3091977954
Fax
027-59420980
Country
China
ProdList
4942
Advantage
58
Shanghai Kewel Chemical Co., Ltd.
Tel
021-64609169 18901607656
Fax
021-64609160
Email
greensnown@163.com
Country
China
ProdList
9906
Advantage
50
SHANGHAI BANGCHENG CHEMICAL Co.,Ltd.
Tel
021-69106960 13701823733
Fax
021-69106780
Email
13701823733@163.com
Country
China
ProdList
4641
Advantage
60
Hangzhou J&H Chemical Co., Ltd.
Tel
0571-87396432
Fax
0571-87396431
Email
sales@jhechem.com
Country
China
ProdList
14912
Advantage
59
Shanghai Song Yuan Chemical Technology Co., Ltd.
Tel
010-1234567 18521000990
Fax
86-021-33275113
Email
sonyuanchemical@163.com
Country
China
ProdList
6479
Advantage
50
Beijing Xinsavi Chemical Technology Co., Ltd.
Tel
010-56218822 13717722232
Fax
010-56218800
Email
xinsavichem@163.com
Country
China
ProdList
3201
Advantage
56
Beijing Holiyang Chemical Co. Ltd.
Tel
13718199399
Fax
QQ : 206661479
Email
holiyangchem@163.com
Country
China
ProdList
3280
Advantage
56
Shanghai YouPeng Chemical Co. Ltd.
Tel
021-69005955 13701776567
Fax
021-69005775
Email
youpengchem@163.com
Country
China
ProdList
4161
Advantage
56
Sichuan Hainuowei Technology Co. Ltd.
Tel
13708085536 13708085536
Fax
QQ : 121102042
Email
hanovichem@163.com
Country
China
ProdList
3282
Advantage
56
Shanghai TongYuan Chemical Co., Ltd.
Tel
021-021-69182866 13701855675
Fax
021-69182022
Email
tongyuanchem@126.com
Country
China
ProdList
4193
Advantage
58
Shanghai Kaisai Chemical Co., Ltd
Tel
021-33516722 13701817765
Fax
021-33516776
Email
kaisaichem@163.com
Country
China
ProdList
4610
Advantage
58
Beijing HuaYangZhicheng Technology Co., Ltd.
Tel
13716033033
Fax
010-56276266
Email
hanchochem@163.com
Country
China
ProdList
2960
Advantage
50
More
Less

View Lastest Price from 6-Amino-1,3-dimethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione manufacturers

Zouping mingyuan import & export trading co., ltd
Product
6-Amino-1,3-dimethyluracil 6642-31-5
Price
US $0.00/kg
Min. Order
1kg
Purity
99
Supply Ability
20 tons
Release date
2025-08-05
Hebei Chuanghai Biotechnology Co., Ltd
Product
6-Amino-1,3-dimethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione 6642-31-5
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
5tons
Release date
2024-12-03
Hebei Zhuanglai Chemical Trading Co Ltd
Product
6-Amino-1,3-dimethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione 6642-31-5
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20 ton
Release date
2024-12-09

6642-31-5, 6-Amino-1,3-dimethyl-1,2,3,4-tetrahydropyrimidine-2,4-dioneRelated Search:

1,3,7-TRIMETHYLURIC ACID aminometradine 1,3-Dimethylurea 6-AMINO-1,3-DIMETHYL-5-NITROSOURACIL 5,6-Diamino-1,3-dimethyluracil hydrate 6-Amino-1,3-dimethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione 1,3-Dimethyluric acid 6-[[3-[4-(2-Methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyluracil TETRAMETHYLURIC ACID Semicarbazide 1,3-Dimethyluracil 6-Aminouracil 1,3-DIMETHYL-6-HYDRAZINOURACIL 6-AMINO-1,3-DIMETHYL-2,4-DIOXO-1,2,3,4-TETRAHYDROPYRIMIDINE-5-CARBALDEHYDE 1,3-DIETHYL-5-NITROSO-6-AMINOURACIL 1,3-DIETHYL-5,6-DIAMINOURACIL 6-AMino-1-isobutyl-3-Methyl-5-nitroso-2,4-pyriMidinedione 1,3-DIETHYL-6-AMINOURACIL

  • AURORA KA-4912
  • 1,3-DIMETHYL-6-AMINOURACIL
  • 1,3-DIMETHYL-4-AMINOURACIL
  • 1,3-DIMETHYL-2,6-DIOXO-4-AMINOTETRAHYDROPYRIMIDINE
  • 4-AMINO-1,3-DIMETHYLURACIL FOR SYNTHESIS
  • 6-AMINO-1,3-DIMETHYLPYRIMIDINE-2,4(1H,3H)-DIONE
  • 6-AMINO-1,3-DIMETHYLURACIL
  • 6-AMINO-1,3-DIMETHYLURICIL
  • 6-AMINO-1,3-DIMETHYL-1,2,3,4-TETRAHYDROPYRIMIDINE-2,4-DIONE
  • 2,4(1H,3H)-Pyrimidinedione, 6-amino-1,3-dimethyl-
  • 4-AMINO-1,3-DIMETHYLURACIL 98+%
  • 6-AMINO-1,3-DIMETHYLURACIL6-AMINO-1,3-DIMETHYL-2,4(1H,3H)-PYRIMIDINEDIONE
  • 3-(4-Nitrophenyl)propionicacidC9H9NO4
  • 6-AMINO-1,3-DIMETHYLURACIL、6-AMINO-1,3-DIMETHYL-2,4(1H,3H)-DIONE
  • Amino-1,3-dimethyluracil,6-
  • 1,3-Dimethyl-6-amino-1,2,3,4-tetrahydropyrimidine-2,4-dione
  • 1,3-Dimethyl-6-amino-2,4(1H,3H)-pyrimidinedione
  • 6-AMINO-1,3-DIMETHYL-1,2,3,4-TETR
  • 4-AMINO-1,3-DIMETHYL-2,6-DIHYDROXYPYRIMIDINE
  • 4-AMINO-1,3-DIMETHYLURACIL
  • TIMTEC-BB SBB004028
  • SPECS AB-323/25048015
  • 3h)-pyrimidinedione,6-amino-1,3-dimethyl-4(1h
  • 6-amino-1,3-dimethyl-2,4(1h,3h)-pyrimidinedione
  • 6-Amino-1,3-dimethyl-2,4-pyrimidinedione
  • 6-amino-1,3-dimethyl-uraci
  • 6-Imino-1,3-dimethyluracil
  • 6-AMINO-1,3-DIMETHYL-2,4(1H,3H)-DIONE
  • Dimethyl- 6-aminouracil
  • 6-amino-1,3-dimethylpyrimidine-2,4-dione
  • 6-Amino-1,3-dimethyluracil &gt
  • Chlorpyrifos Impurity 21
  • 6-Amino-1,3-di methyluracil in Acetonitrile
  • Uradil impurity 42
  • 6-Amino-1,3-dimetyl uracil
  • 6642-31-5
  • 4316-44-9
  • Heterocyclic Building Blocks
  • Pyrimidines
  • Building Blocks
  • Amines
  • Building Blocks
  • Heterocyclic Building Blocks
  • Pyrimidines
  • bc0001