Urapidil hydrochloride

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Urapidil hydrochloride

Product Name: Urapidil hydrochloride
CAS No.: 64887-14-5
Chemical Name: Urapidil hydrochloride
Synonyms: URAPIDIL HCL;Urapidil hydrochoride;URAPIDIL HYDROCHLORIDE;Eposin Etopophos Vepesid VP16;Urapidil hydrochloride USP/EP/BP;Urapidil HCl,Urapidil Hydrochloride;3-methyl-3-hydroxymethyloxyheterocyclobutane;URAPIDIL HYDROCHLORIDE A1 ADRENOCEPTOR A NTAG;6[[3-[4-(O-METHOXYPHENYL)-1-PIPERAZINYL]PROPYL]AMINO]-1,3-DIMETHYLURACIL HYDROCHLORIDE;6-[[3-[4-(2-Methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyluracil hydrochloride
CBNumber: CB6332466
Molecular Formula: C20H30ClN5O3
Formula Weight: 423.94
MOL File: 64887-14-5.mol

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Urapidil hydrochloride Property

Melting point:: 156-1580C
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: H₂O: soluble
form: solid
color: white
Water Solubility: Soluble to 50 mM in water
InChI: InChI=1S/C20H29N5O3.ClH/c1-22-18(15-19(26)23(2)20(22)27)21-9-6-10-24-11-13-25(14-12-24)16-7-4-5-8-17(16)28-3;/h4-5,7-8,15,21H,6,9-14H2,1-3H3;1H
InChIKey: KTMLZVUAXJERAT-UHFFFAOYSA-N
SMILES: O(C1C=CC=CC=1N1CCN(CCCNC2=CC(=O)N(C)C(=O)N2C)CC1)C.Cl

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Safety

Hazard Codes: Xn
Risk Statements: 22-36/37/38
Safety Statements: 26-36
WGK Germany: 3
RTECS: YQ9862000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: U100
Product name: Urapidil hydrochloride
Purity: solid
Packaging: 100mg
Price: $173
Updated: 2023/06/20

Sigma-Aldrich

Product number: U100
Product name: Urapidil hydrochloride
Purity: solid
Packaging: 500mg
Price: $691
Updated: 2023/06/20

Alfa Aesar

Product number: J63219
Product name: Urapidil hydrochloride, 98+%
Packaging: 1g
Price: $191
Updated: 2023/06/20

Alfa Aesar

Product number: J63219
Product name: Urapidil hydrochloride, 98+%
Packaging: 5g
Price: $605
Updated: 2021/12/16

Cayman Chemical

Product number: 29004
Product name: Urapidil (hydrochloride)
Packaging: 250mg
Price: $73
Updated: 2024/03/01

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Urapidil hydrochloride Chemical Properties,Usage,Production

Description

Urapidil is an antagonist of α₁-adrenergic receptors (α₁-ARs) and a partial agonist of the serotonin (5-HT) receptor subtype 5-HT_1A. It selectively binds to α₁- over α₂-ARs (IC₅₀s = 0.74 and 42 μM, respectively) and to 5-HT_1A over 5-HT_1B and 5-HT₂ receptors (IC₅₀s = 0.4, 20.4, and >10 μM, respectively) in rat cortex. Urapidil inhibits cAMP accumulation induced by forskolin in calf hippocampus as a functional model for 5-HT_1A receptors (EC₅₀ = 390 nM). It is also a β₁-AR antagonist that inhibits the positive chronotropic response induced by isoproterenol in isolated rat atria (pA₂ = 6.05). Urapidil (1 μmol/kg, i.v.) lowers mean arterial pressure (MAP) in anesthetized cats, an effect that is reduced by central administration of the 5-HT_1A receptor antagonist spiroxatrine.

Chemical Properties

White to Off-White Crystalline Powder

Uses

α1-Adrenergic antagonist; derivative of Uracil (U801000). Antihypertensive.

Uses

Antihypertensive;Serotonergic receptor agonist

Uses

a1-Adrenergic antagonist; derivative of Uracil. Antihypertensive

Biological Activity

α 1 -adrenoceptor antagonist and 5-HT 1A receptor agonist (pIC 50 values are 6.13 and 6.4 respectively). Clinically used hypotensive agent.

Side effects

Side effects that may occur during treatment with uradil antihypertension include dizziness, fatigue, nausea, and light-headedness effects. The increases in systolic blood pressure heart rate caused by three progressive work loads bicycle exercise were not affected during urapidil, A slight reduction in forced expiratory volume was observed in some patients during treatment with beta-blocker. There was no case orthostatic hypotension during urapidil administration, despite its alpha1-blocking action. Side-effects were rare negligible^[1].

References

[1] G LEONETTI. Comparison of the antihypertensive effect of urapidil and metoprolol in hypertension.[J]. European Journal of Clinical Pharmacology, 1986, 30 6: 637-640. DOI:10.1007/BF00608208.

Urapidil hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Urapidil hydrochloride manufacturers

Ouhuang Engineering Materials (Hubei) Co., Ltd

Product: Urapidil Hydrochloride 64887-14-5
Price: US $30.00/kg
Min. Order: 1kg
Purity: 99.7%
Supply Ability: 200000kg
Release date: 2024-04-18

Ouhuang Engineering Materials (Hubei) Co., Ltd

Product: Urapidil Hydrochloride 64887-14-5
Price: US $50.00/kg
Min. Order: 1kg
Purity: 99.912%
Supply Ability: 10ton
Release date: 2024-04-12

Ouhuang Engineering Materials (Hubei) Co., Ltd

Product: Urapidil hydrochloride 64887-14-5
Price: US $50.00/kg
Min. Order: 1kg
Purity: 99.10%
Supply Ability: 50000kg
Release date: 2024-04-16

64887-14-5, Urapidil hydrochlorideRelated Search:

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6[[3-[4-(O-METHOXYPHENYL)-1-PIPERAZINYL]PROPYL]AMINO]-1,3-DIMETHYLURACIL HYDROCHLORIDE

6-[[3-[4-(2-METHOXYPHENYL)-1-PIPERAZINYL]PROPYL]AMINO]-1,3-DIMETHYL-2,4(1H,3H)-PYRIMIDINEDIONE

6-[[3-[4-(2-METHOXYPHENYL)-1-PIPERAZINYL]PROPYL]AMINO]-1,3-DIMETHYL-2,4(1H,3H)-PYRIMIDINEDIONE HYDROCHLORIDE

URAPIDIL HCL

URAPIDIL HYDROCHLORIDE

URAPIDIL HYDROCHLORIDE A1 ADRENOCEPTOR A NTAG

6-[3-[4-(2-methoxyphenyl)piperazin-1-yl]propylamino]-1,3-dimethyl-pyrimidine-2,4-dione hydrochloride

6-[3-[4-(2-methoxyphenyl)piperazin-1-yl]propylamino]-1,3-dimethylpyrimidine-2,4-dione hydrochloride

6-[3-[4-(2-methoxyphenyl)piperazin-1-yl]propylamino]-1,3-dimethyl-pyrimidine-2,4-quinone hydrochloride

6-[[3-[4-(2-methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyl-2,4(1H,3H)-pyrimidinedione,hydrochloride (1:1)

2,4(1H,3H)-Pyrimidinedione,6-[[3-[4-(2-methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyl-,hydrochloride (

6-[[3-[4-(2-Methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyluracil hydrochloride

Urapidil hydrochloride USP/EP/BP

Urapidil hydrochoride

3-methyl-3-hydroxymethyloxyheterocyclobutane

6-((3-(4-(2-Methoxyphenyl)piperazin-1-yl)propyl)amino)-1,3-dimethylpyrimidine-2,4(1H,3H)-dione hydrochloride

Urapidil HCl,Urapidil Hydrochloride

Eposin Etopophos Vepesid VP16

64887-14-5

C20H30ClN5O3

C20H29N5O3HCl

Adrenoceptor

Intermediates & Fine Chemicals

Pharmaceuticals

64887-14-5