Clevidipine butyrate

Product Name: Clevidipine butyrate
CAS No.: 167221-71-8
Chemical Name: Clevidipine butyrate
Synonyms: Cleviprex;CS-136;Clevelox;H 324/38;evidipine;rac-Clevidipine;4-b-D-Xylopentaose;Clevidipine butyrate;Cloweidipine butyrate;CLEVELOX; CLEVIDIPINE
CBNumber: CB01248667
Molecular Formula: C21H23Cl2NO6
Formula Weight: 456.32
MOL File: 167221-71-8.mol

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Clevidipine butyrate Property

Melting point:: 128-130°C
Boiling point:: 539.7±50.0 °C(Predicted)
Density: 1.289
Flash point:: 280℃
storage temp.: Keep in dark place,Inert atmosphere,2-8°C
Water Solubility: Insoluble in water
solubility: ≥21.4 mg/mL in DMSO; insoluble in H2O; ≥7.45 mg/mL in EtOH with ultrasonic
form: powder to crystal
pka: 2.45±0.70(Predicted)
color: White to Light yellow
CAS DataBase Reference: 167221-71-8

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Safety

Safety Statements: 24/25
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H361Suspected of damaging fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P281Use personal protective equipment as required.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical

Product number: C3503
Product name: Clevidipine
Purity: >98.0%(HPLC)
Packaging: 250mg
Price: $69
Updated: 2024/03/01

TCI Chemical

Product number: C3503
Product name: Clevidipine
Purity: >98.0%(HPLC)
Packaging: 1g
Price: $190
Updated: 2024/03/01

Cayman Chemical

Product number: 23025
Product name: Clevidipine Butyrate
Purity: ≥98%
Packaging: 10mg
Price: $81
Updated: 2024/03/01

Cayman Chemical

Product number: 23025
Product name: Clevidipine Butyrate
Purity: ≥98%
Packaging: 25mg
Price: $140
Updated: 2024/03/01

Cayman Chemical

Product number: 23025
Product name: Clevidipine Butyrate
Purity: ≥98%
Packaging: 50mg
Price: $258
Updated: 2024/03/01

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Clevidipine butyrate Chemical Properties,Usage,Production

Description

Clevidipine is an ultra-short-acting vasodilator of the dihydropyridine (DHP) class of CCB. It is indicated as an intravenous treatment for the acute management of hypertension when oral therapy is not feasible or not desirable. Clevidipine is the second intravenous CCB to be marketed behind nicardipine for this indication. Both agents are primarily used for urgent treatment of hypertension in cardiac surgical setting, intensive care units, and emergency departments. Other intravenous agents currently on the market for this indication include sodium nitroprusside, nitroglycerin, fenoldopam, hydralazine, esmolol, and labetalol. Clevidipine is a potent, arterial-specific, vasodilator with very little or no effect on the myocardial contractility and venous capacitance. It has a rapid onset and offset of action and a very short plasma half-life, which allows for titration of the drug to achieve precise BP control.
clevidipine is exclusively metabolized in the blood and the tissues. It does not undergo any renal or hepatic metabolism and does not accumulate in the body. Clevidipine is a blocker of L-type calcium channels, which mediate the influx of calcium during depolarization in arterial smooth muscle.

Chemical Properties

White to Off-White Solid

Originator

AstraZeneca (United Kingdom)

Uses

Clevidipine butyrate is a dihydropyridine calcium channel blocker use as agent for the reduction of blood pressure。

Uses

Calcium channel blocker, used as an oral antihypertensive.

Uses

Clevidipine butyrate is a novel intravenous, short-acting calcium channel blocker that provides quick and accurate control of blood pressure in an emergency setting. Unlike other intravenous hypertension drugs which are metabolized in kidney or liver and tend to accumulate in the body, clevidipine is metabolized in the blood and tissues and thus avoids accumulation. The drug was launched by Medicines Company which aquired the rights from AstraZeneca.

Uses

A calcium channel protein inhibitor and blocker

Definition

ChEBI: Clevidipine is a dihydropyridine.

brand name

Clevelox (The Medicines Company).

Side effects

Clevidipine is contraindicated in patients with severe aortic stenosis, defective lipid metabolism, and allergies to eggs, egg products, soybeans, or soy products. The chemical synthesis of clevidipine entails the esterification of 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid monomethyl ester with chloromethyl butyrate by the action of potassium bicarbonate in refluxing acetonitrile.

Synthesis

The chemical synthesis of clevidipine entails the esterification of 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid monomethyl ester with chloromethyl butyrate by the action of potassium bicarbonate in refluxing acetonitrile. The DHP-monoester starting material is obtained in two steps through condensation of methyl 2,3-dichlorobenzylidine acetoacetate and 2-cyanoethyl ester of 2-amino-2-propenoic acid to the DHP diester, followed by base catalyzed cleavage of the cyanoethyl group. Clevidipine is practically insoluble in water and is formulated in an oil-inwater emulsion.

Clevidipine butyrate Preparation Products And Raw materials

Raw materials

Preparation Products

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Clevidipine butyrate Suppliers

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View Lastest Price from Clevidipine butyrate manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Clevidipine butyrate 167221-71-8
Price: US $0.00/Kg/Bag
Min. Order: 1g
Purity: 99%min
Supply Ability: 10kgs
Release date: 2021-07-16

Hebei Weibang Biotechnology Co., Ltd

Product: Clevidipine butyrate 167221-71-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-15

Henan Bao Enluo International TradeCo.，LTD

Product: Clevidipine butyrate 167221-71-8
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1000tons
Release date: 2023-07-24

167221-71-8, Clevidipine butyrateRelated Search:

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Clevidipine butyrate

Cleviprex

Clevidipine, Cleviprex

CS-136

CLEVELOX; CLEVIDIPINE

Cloweidipine butyrate

4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-diMethyl-3,5-pyridinedicarboxylic Acid 3-Methyl 5-[(1-Oxobutoxy)Methyl] Ester

Clevelox

H 324/38

rac-Clevidipine

Clevidipine Butyrate/Cleviprex

Cleviprex Clevidipine butyrate

Cleviprex (Clevidipine)

Butyric acid Clevidipine

3-((Butyryloxy)methyl) 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-di

5-O-(butanoyloxymethyl) 3-O-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

evidipine

3-((Butyryloxy)methyl) 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

4-(2,3-Dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic Aicd 3-[(Butyryloxy)methyl] 5-Methyl Ester

Clevidipine butyrate USP/EP/BP

Methyl (1-oxobutoxy)methyl 4-(2,3-dichlorophenyl)-1,4-dihydr...

Clevidipine ButyrateQ: What is Clevidipine Butyrate Q: What is the CAS Number of Clevidipine Butyrate Q: What is the storage condition of Clevidipine Butyrate Q: What are the applications of Clevidipine Butyrate

4-b-D-Xylopentaose

Clevidipine Reference

3-Aminocrotonic acid cinnamy ester

167221-71-8

166432-28-9

Aromatics

Heterocycles

Intermediates & Fine Chemicals

Cardiovascular APIs

Clevidipine Butyrate impurity

Pharmaceuticals

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